Protein Alignment CDK2 and Cdk4

DIOPT Version :9

• Sequence 1: XP_011536034.1
• Gene: CDK2 / 1017
• HGNCID: 1771
• Length: 346
• Species: Homo sapiens
• Sequence 2: NP_001286493.1
• Gene: Cdk4 / 36854
• FlyBaseID: FBgn0016131
• Length: 317
• Species: Drosophila melanogaster
• Alignment Length: 346
• Identity: 145/346 - (41%)
• Similarity: 188/346 - (54%)
• Gaps: 70/346 - (20%)

Human     3 NFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL---NHPNIV 64
            |:|::..||||.||.||:||:.:||.:|||||:|:.....|||.:.:|||||||:|   ||.|||
  Fly    25 NYQELNIIGEGAYGTVYRARDVITGNIVALKKVRISLNENGVPMSTLREISLLKQLNASNHANIV 89

Human    65 KLLDV---IHTENKL--YLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVL 124
            ||.:|   :..:.:|  .||||.:.|||...:|....:|:..|.|:....:||.|:.|.||||::
  Fly    90 KLYEVCQFLERDGQLLILLVFEHVEQDLSDLIDRLPKSGMSPPTIQRLSRELLTGVDFLHSHRII 154

Human   125 HRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSL 189
            ||||||||||::::|.:|:||||||:.:|..:: .|..||||||||||:||...|.|| |||||.
  Fly   155 HRDLKPQNLLVSSQGHLKIADFGLAKTYGSEMK-LTSVVVTLWYRAPEVLLAQPYNST-VDIWSA 217

Human   190 GCIFAEMHLVGTQHHARCCGEHRRNGRQSLCPLCSYLEVAASQGWGMTAVSTPYPVTRRALFPGD 254
            .||..||                                                ..|||||||.
  Fly   218 ACIIFEM------------------------------------------------FNRRALFPGT 234

Human   255 SEIDQLFRIFRTLGTPDEVVWPGVTSM-----PDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQM 314
            ||.:||.|||...|.|.|..||...|:     |...|..||    ||   .|.|.:....||::|
  Fly   235 SEKNQLDRIFELTGRPTEQQWPQTISVALEHFPQRHPKRPK----DF---CPHLCKYADDLLNKM 292

Human   315 LHYDPNKRISAKAALAHPFFQ 335
            |.||.:.|.||.|.|.|.:||
  Fly   293 LSYDLHLRPSALACLEHDYFQ 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK2	XP_011536034.1	STKc_CDK2_3	3..334	CDD:270844	143/343 (42%)
Cdk4	NP_001286493.1	STKc_CDK4_6_like	26..312	CDD:270831	142/342 (42%)
		S_TKc	26..312	CDD:214567	142/342 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0594
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810