DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CDK2 and Cdk5

DIOPT Version :9

Sequence 1:	XP_011536034.1	Gene:	CDK2 / 1017	HGNCID:	1771	Length:	346	Species:	Homo sapiens
Sequence 2:	NP_477080.1	Gene:	Cdk5 / 36727	FlyBaseID:	FBgn0013762	Length:	294	Species:	Drosophila melanogaster

Alignment Length:	339	Identity:	174/339 - (51%)
Similarity:	224/339 - (66%)	Gaps:	54/339 - (15%)

- Green bases have known domain annotations that are detailed below.

Human     1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVK 65
            |:.:.|:|||||||||.|:|.||:.|.|:||||::|||.:.|||||:|:|||.|||||.|.|||:
  Fly     1 MQKYDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNIVR 65

Human    66 LLDVIHTENKLYLVFEFLHQDLKKFMDASALTG-IPLPLIKSYLFQLLQGLAFCHSHRVLHRDLK 129
            |:||:|::.||.||||...|||||:.|  :|.| |.:.:.:|::.|||:||||||||.|||||||
  Fly    66 LIDVLHSDKKLTLVFEHCDQDLKKYFD--SLNGEIDMAVCRSFMLQLLRGLAFCHSHNVLHRDLK 128

Human   130 PQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFA 194
            |||||||..|.:||||||||||||:||:.|:.||||||||.|::|.|.|.|:|::|:||.|||.|
  Fly   129 PQNLLINKNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSAGCILA 193

Human   195 EMHLVGTQHHARCCGEHRRNGRQSLCPLCSYLEVAASQGWGMTAVSTPYPVTRRALFPGDSEIDQ 259
            |:...|                                               |.||||...:||
  Fly   194 ELADAG-----------------------------------------------RPLFPGSDVLDQ 211

Human   260 LFRIFRTLGTPDEVVWPGVTSMPDY--KPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKR 322
            |.:|||.||||:|..||||:.:.||  .||||  |...:|::||.|:..||.||.::|...||:|
  Fly   212 LMKIFRVLGTPNEDSWPGVSHLSDYVALPSFP--AITSWSQLVPRLNSKGRDLLQKLLICRPNQR 274

Human   323 ISAKAALAHPFFQD 336
            |||:||:.||:|.|
  Fly   275 ISAEAAMQHPYFTD 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDK2	XP_011536034.1	STKc_CDK2_3	3..334	CDD:270844	171/333 (51%)
Cdk5	NP_477080.1	PLN00009	1..288	CDD:177649	173/337 (51%)
Cdk5	NP_477080.1	STKc_CDK5	3..286	CDD:143344	171/333 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1010560at2759
OrthoFinder	1	1.000	-	-		FOG0000411
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100334
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R185
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850