DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CDK2 and cdc2

DIOPT Version :9

Sequence 1:	XP_011536034.1	Gene:	CDK2 / 1017	HGNCID:	1771	Length:	346	Species:	Homo sapiens
Sequence 2:	NP_001342995.1	Gene:	cdc2 / 2539869	PomBaseID:	SPBC11B10.09	Length:	297	Species:	Schizosaccharomyces pombe

Alignment Length:	343	Identity:	194/343 - (56%)
Similarity:	238/343 - (69%)	Gaps:	55/343 - (16%)

- Green bases have known domain annotations that are detailed below.

Human     1 MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKEL----NHP 61
            |||:||||||||||||||||||:||:|.:||:|||||:.|:||||||||||||||||:    |..
pombe     1 MENYQKVEKIGEGTYGVVYKARHKLSGRIVAMKKIRLEDESEGVPSTAIREISLLKEVNDENNRS 65

Human    62 NIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTG---IPLPLIKSYLFQLLQGLAFCHSHRV 123
            |.|:|||::|.|:|||||||||..||||:||..:.||   :...|::.:.:||:.|:.||||.|:
pombe    66 NCVRLLDILHAESKLYLVFEFLDMDLKKYMDRISETGATSLDPRLVQKFTYQLVNGVNFCHSRRI 130

Human   124 LHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWS 188
            :|||||||||||:.||.:|||||||||:||||:|.||||:|||||||||:|||.::|||.|||||
pombe   131 IHRDLKPQNLLIDKEGNLKLADFGLARSFGVPLRNYTHEIVTLWYRAPEVLLGSRHYSTGVDIWS 195

Human   189 LGCIFAEMHLVGTQHHARCCGEHRRNGRQSLCPLCSYLEVAASQGWGMTAVSTPYPVTRRALFPG 253
            :|||||||                                                :.|..||||
pombe   196 VGCIFAEM------------------------------------------------IRRSPLFPG 212

Human   254 DSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYD 318
            |||||::|:||:.||||:|.||||||.:.|||.:||:|.|.|..||||..:||...|||.||.||
pombe   213 DSEIDEIFKIFQVLGTPNEEVWPGVTLLQDYKSTFPRWKRMDLHKVVPNGEEDAIELLSAMLVYD 277

Human   319 PNKRISAKAALAHPFFQD 336
            |..|||||.||...:.:|
pombe   278 PAHRISAKRALQQNYLRD 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDK2	XP_011536034.1	STKc_CDK2_3	3..334	CDD:270844	191/337 (57%)
cdc2	NP_001342995.1	STKc_CDK1_CdkB_like	4..293	CDD:270829	190/336 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	390	1.000	Domainoid score	I134
eggNOG	1	0.900	-	-		E1_KOG0594
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74409
Inparanoid	1	1.050	399	1.000	Inparanoid score	I440
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000411
OrthoInspector	1	1.000	-	-		otm53583
orthoMCL	1	0.900	-	-		OOG6_100334
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R185
SonicParanoid	1	1.000	-	-		X960
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.850