DRSC/TRiP Functional Genomics Resources

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Protein Alignment CDH18 and CadN2

DIOPT Version :9

Sequence 1:NP_001278885.1 Gene:CDH18 / 1016 HGNCID:1757 Length:790 Species:Homo sapiens
Sequence 2:NP_001036368.2 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster


Alignment Length:573 Identity:171/573 - (29%)
Similarity:266/573 - (46%) Gaps:108/573 - (18%)


- Green bases have known domain annotations that are detailed below.


Human    85 DGSVK------YILTGEG------AGTIFIIDDTTGDIHSTKSLDREQ-----KTHYVLHAQAID 132
            ||.|.      |.|||:|      |.:.|.|:.|||||...|.|||:|     :..:.:.||   
  Fly   164 DGDVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQPNGRPQWRFTVFAQ--- 225

Human   133 RRTNKPLEPESEFIIKVQDINDNAPKFTDGPYIVTVPEMSDMGTSVLQVTATDADDPTYGNSARV 197
            ....:.|...::..:.::|||||||:|..|.|...|.|....|:||:.::|.|.|||....:|::
  Fly   226 DEGGEGLVGYADIQVNLKDINDN
APQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNAKL 290

Human   198 VYSILQ-------GQPYFSVDPKTGVIRTALHNMDREAREHYSVVIQAKDMAGQVGGLSGSTTVN 255
            :|||.:       |.|.|.::|:||:|:||:..:|||....||:.:.|.|    .|||.|:.|.:
  Fly   291 IYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVVAMD----GGGLKGTGTAS 351

Human   256 ITLTDVNDNPPRFPQKHY--------QLYVPESAQVGSAVGKIKANDAD------------TGSN 300
            |.:.|:||.||:|.:..:        ..|:||     :.:..:...|.|            :|..
  Fly   352 IRVKDLND
MPPQFTKDEWVTEVDETNGTYIPE-----TPILTVTVQDEDETNTFQYKVVPNSGFG 411

Human   301 ADMTYSIINGDGMGIFSISTDKETREGILSLK--KPLNYE---KKKSYTLNIE---------GAN 351
            ||....:.||||.|               |||  :||:||   :...:...|:         |.:
  Fly   412 ADKFAMVRNGDGTG---------------SLKIIQPLDYEDPLQSSGFRFRIQVNDKGDDGPGGS 461

Human   352 THLDFRFSHLGPFKDATMLKIIVGDV-DEPPLFSMPSYLMEVYENAKIGTVVGTVLAQDPD-STN 414
            ......:|         .:.:.:.|: |..|.|......:.:||:.|:||::....|.|.| ..:
  Fly   462 DKYHVAYS---------WVVVKLRDINDN
VPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGH 517

Human   415 SLVRYFINYNVEDDRFFNIDANTGTIRTTKVLDREETPWYNITVTASEIDNPDLLSHVTVGIRVL 479
            |.|.|.|..:....|.|.| ::.|.:...:.||||....::|.:.|.:..:|...:..|:.:.|.
  Fly   518 SKVAYKIVRSTNRKRQFAI-SDRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVK 581

Human   480 DVNDNPPELAREYDIIVCENSKPGQVIHTISATDKDD--FANGPRFNFFLDERL--PVNPNFTLK 540
            |||||.|..|::|...:.||.. |:.|..::|.|.||  ..||..|.|.||...  .:...|.::
  Fly   582 DVNDN
APTFAQDYKPTLPENVS-GKKILEVAAKDPDDRLRGNGGPFTFRLDPLASDEIKAGFKVE 645

Human   541 -----DNEDNTASILTRRRRFSRTVQDVYYLPIMISDGGIPSLSSSSTLTIRV 588
                 ||| |..:|::..|.|.|..|..|.:||.|.|.|.|:::.:||||:.:
  Fly   646 YDRRGDNE-NGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTI 697

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CDH18NP_001278885.1 CA 79..157 CDD:214520 29/88 (33%)
Cadherin_repeat 163..264 CDD:206637 39/107 (36%)
Cadherin_repeat 272..379 CDD:206637 24/141 (17%)
Cadherin_repeat 387..484 CDD:206637 28/97 (29%)
Cadherin_repeat 491..589 CDD:206637 36/107 (34%)
Cadherin_C 637..783 CDD:307269
CadN2NP_001036368.2 Cadherin_repeat 41..132 CDD:206637
Cadherin_repeat 140..248 CDD:206637 27/86 (31%)
Cadherin_repeat 256..359 CDD:206637 38/106 (36%)
Cadherin_repeat 379..481 CDD:206637 24/130 (18%)
Cadherin_repeat 489..586 CDD:206637 28/97 (29%)
Cadherin_repeat 594..703 CDD:206637 36/106 (34%)
Cadherin_repeat 724..801 CDD:206637
EGF_CA 977..1010 CDD:238011
LamG 1013..1198 CDD:238058
EGF_2 <1233..1259 CDD:285248
Laminin_G_2 1293..1428 CDD:280389
EGF_CA 1497..1535 CDD:238011
Cadherin_C 1583..1719 CDD:279398
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 130 1.000 Domainoid score I5199
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24027
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
33.010

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