Protein Alignment ATP6AP2 and ATP6AP2

DIOPT Version :10

• Sequence 1: NP_005756.2
• Gene: ATP6AP2 / 10159
• HGNCID: 18305
• Length: 350
• Species: Homo sapiens
• Sequence 2: NP_649876.1
• Gene: ATP6AP2 / 41104
• FlyBaseID: FBgn0037671
• Length: 320
• Species: Drosophila melanogaster
• Alignment Length: 358
• Identity: 94/358 - (26%)
• Similarity: 168/358 - (46%)
• Gaps: 48/358 - (13%)

Human     1 MAVFVVLLALVAGV-LGNEFSILKSPGSVVFRNGNWPIPGERIPDVAALSMGFSVKEDLSWPGLA 64
            :.|||:....:|.: ...||::|..|.::.|: ||..:....:.||...|||.:|..|.:|.||.
  Fly     2 LRVFVIFSLFIAAINASGEFTVLNRPKAISFK-GNDALESHYVGDVLYASMGNAVSGDTNWNGLT 65

Human    65 VGNLFHRPRATVMVMVKGVNKLALPPGSVISYPLENAVPFSLDSVANSIHSLFSEETPVVLQLAP 129
            :.:.|:..:..::|.|:|:..:. ..|:|.:|.|..:   ..|:..|::          ..:|..
  Fly    66 INDPFNLAKGVILVHVQGIGHVT-TAGNVKTYELTGS---GTDASLNAL----------AAELEA 116

Human   130 SEERVYMVGKANSVFEDLSVTLRQLRNRLFQENSVLSSLPLNSLSRNNEVDLLFLSELQVLHDIS 194
            :.|.|..:.     ||.....::..:: .|.:....::.|...|:.:     |..::.|.|.::.
  Fly   117 ANEPVCDIN-----FEQFDDGVQAWKS-CFGDFEAPAAKPTKHLNPS-----LHTADKQFLQEVG 170

Human   195 SLLSRHKHLAKDHSPDLYSLELAGLDEIGKRYGEDSEQFRDASKILVDALQKFADDMYSLYGGNA 259
            .:.|...|||:...|....:....:|.:.|.:||.|....:|:|:|..|:.:..
  Fly   171 FINSAADHLAEMAKPSNVLMLRVSVDGVAKAHGEKSVAVEEANKLLSAAISRLL----------- 224

Human   260 VVELVTVKSFDTSL-IRKTRTILEAKQAK------NPASPYNLAYKYNFEYSVVFNMVLWIMIAL 317
               ..:.||.|:.| ::.|...:.|.:||      :..:|||||..|..:|.|:||::||.|:..
  Fly   225 ---AASQKSSDSVLFVQTTEKDVAASRAKRDTIAASTTNPYNLAVYYGSDYPVIFNIILWFMVVF 286

Human   318 ALAVIITSYNIWNMDPGYDSIIYRMTNQKIRMD 350
            .|:::...|.|..||||.||||||||:.:|:.|
  Fly   287 GLSLLAICYAIAAMDPGRDSIIYRMTSTRIKKD 319

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP6AP2	NP_005756.2	Renin_r	254..350	CDD:462287	37/102 (36%)
		Mediates retrograde transport to the ER. /evidence=ECO:0000269|PubMed:29127204	346..350		1/3 (33%)
ATP6AP2	NP_649876.1	Renin_r	231..319	CDD:462287	26/94 (28%)