Protein Alignment ADGRG2 and mthl1

DIOPT Version :9

• Sequence 1: NP_001073327.1
• Gene: ADGRG2 / 10149
• HGNCID: 4516
• Length: 1017
• Species: Homo sapiens
• Sequence 2: NP_001285340.1
• Gene: mthl1 / 32637
• FlyBaseID: FBgn0030766
• Length: 676
• Species: Drosophila melanogaster
• Alignment Length: 739
• Identity: 153/739 - (20%)
• Similarity: 257/739 - (34%)
• Gaps: 206/739 - (27%)

Human   299 IQPLSPQPSAPIASSPAIDMPPQSETISSPMPQTHVSGTPPPVKASFSSPTVSAPANVNTTSAPP 363
            |:.:||.|:||...||                       ||.||.
  Fly    38 IEEMSPPPAAPPRPSP-----------------------PPTVKL-------------------- 59

Human   364 VQTDIVNTSSISDLENQVLQMEKALSLGSLEPNLAGE------MINQVSRLLHSPPDMLAPLAQR 422
                           |:.....:.|:.|:.   :||.      |:..|.:.....|...:|   |
  Fly    60 ---------------NKCCHSGEYLNDGTC---IAGSEALWLPMVYLVQQQRFFEPHGASP---R 103

Human   423 LLKVVDDIGLQLNFSNTTISLTSPSLALAVIRVNASSFNTTTFVAQDPANLQVSLETQAPENSIG 487
            .||.:.:.........||....|..       .|...|...|...::.| |.|.......:..:.
  Fly   104 FLKFLPNTRPTCRKDQTTEIFRSRG-------ANVMLFPNGTLYVRERA-LMVQPSDYCVDWEVA 160

Human   488 TITLPSSLMNNLPAHDMELASRVQFNFFETPALFQDPSLENLSLI-------SYVISSSVANLTV 545
            .:.|..|    .|.:.:|     ..::...|.:.|:|...:|.|.       ||  ::.:.|..:
  Fly   161 VVCLNDS----QPINALE-----DPDYAANPLVQQEPPKASLRLSKCCGKWGSY--NTQLQNCDL 214

Human   546 RNLTRNVTVTLKHINPSQDELTVRCVFW--DLGRNGG---RGGWSD------------------- 586
            :...:.....|..::|...|.:.:..:.  |.|:.||   .|.|.|
  Fly   215 QPNHQAAVDGLLRLSPQLPEGSYQTSYGLPDCGQPGGYSIAGDWQDAKLDRNTAMLQLPHKNLSA 279

Human   587 -NGCSVKDRRLNET-ICTCSHL-----------TSFGVLLDLSRTSVLPAQMMALTFITYIGCGL 638
             ..|....:|..|. |..|.||           .|.|..::.:....|  |...||.    |..:
  Fly   280 GQYCLEHTQREGEVKIIACQHLFSSAAGAGIHDGSIGGTIEQANGQNL--QKAVLTG----GILV 338

Human   639 SSIFLSVTLVTYIAFEKIRRDYPSKILIQLC-AALLLLNLVFL----LDSWIALYKMQGLCISVA 698
            |.:|||.|||.......:......:  .|:| ...||...:.|    |.|  :|......|.::|
  Fly   339 SIVFLSATLVAGFLLPAVHHALHWR--CQICYVTCLLFGKILLAIEELSS--SLQPGSAACHTLA 399

Human   699 VFLHYFLLVSFTWMGLEAFHMYLALVKVFNTY-----------IRKYILKFCIVGWGVPAVVVTI 752
            :.:.:|.|.:|.|:....|:::.    .|..:           :|:|:  :.:..||.|.::..:
  Fly   400 ITMQFFFLAAFFWLNTMCFNIWW----TFRDFRPSSLERNQEALRRYL--YSLYAWGGPLLITFV 458

Human   753 ILTIS--PDNYGL-GSYGKFPNGSPDDFCWINNN-----AVFYITVVGYFCVIFLLNVSMFIVVL 809
            ...:.  |:...| ..:|:.       :||.:|.     |.||    |...::...|:::|:...
  Fly   459 AACVDQLPETTLLRPGFGQL-------YCWFDNRNLSIFAYFY----GPIGLLLCANIALFVSTT 512

Human   810 VQL-CRIKKKKQLGAQRKTSIQDLRSIAGLTFLLGITWGFAFFAW---GPVNVTFMYLFAIFNTL 870
            .|| |.:.|:..:.:..:.|... |....|..::|:||.....:|   ||..|.|  ...:.|.|
  Fly   513 HQLTCGLWKRDDVKSSSEKSALG-RVCLKLVVVMGVTWIADILSWLVGGPHGVWF--FTDLINAL 574

Human   871 QGFFIFIFY-CVAKENVRKQWR--RYLCCGKLRLAENSDWSKTATNGLKKQTVNQGVSSSSNSLQ 932
            ||.||||.. |..     :.|.  |.:.|.:||    .|.:.| |||::..:.:||:.|.:...:
  Fly   575 QGVFIFIVVGCQP-----QVWTACRRIFCPRLR----HDITNT-TNGVQHSSSSQGLPSMAGGTE 629

Human   933 SSSNSTNSTTLLVNNDCSVHASGN 956
            .:.|:|.:||  ..|..:.|...|
  Fly   630 ITQNTTTTTT--TTNTTATHMPSN 651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADGRG2	NP_001073327.1	GPS	569..612	CDD:280071	16/79 (20%)
		7tm_4	625..875	CDD:304433	62/277 (22%)
mthl1	NP_001285340.1	7tm_4	329..579	CDD:304433	62/277 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4193
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810