Protein Alignment AKAP9 and Plp

DIOPT Version :10

• Sequence 1: NP_005742.4
• Gene: AKAP9 / 10142
• HGNCID: 379
• Length: 3907
• Species: Homo sapiens
• Sequence 2: NP_001027574.2
• Gene: Plp / 3772382
• FlyBaseID: FBgn0086690
• Length: 2895
• Species: Drosophila melanogaster
• Alignment Length: 3722
• Identity: 732/3722 - (19%)
• Similarity: 1288/3722 - (34%)
• Gaps: 1225/3722 - (32%)

Human   375 NMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFE------------------------ 415
            |:..|...|..::.|.:|:.:.:.|.|.:.:..:..||..:
  Fly    69 NIIFEKPTSSSEQLQCAEKSEHVAGGVSDKEPADDCDSDNDSTRTYIISRSSWTGVTSSSSTPYA 133

Human   416 ---TDIVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRS 477
               ||..:.:.::....|    .|.|:......::.....|...||......|...........|
  Fly   134 VTSTDTAELLRRQNNLSL----TEEDQSVSSFSIEQPTSSITIEMADQRTTTTTTTTATTATTPS 194

Human   478 YSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSRE 542
            .:||        |...|.....     |:|..|:..||...|.|.:..|...||.|.|..:::|.
  Fly   195 SANI--------LATTATTTTT-----TSSSIEEEIEEAIEISEVEEQLNTPLESLSEAAAYARP 246

Human   543 QIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEK 607
            :        .||.|.     ||||:   ..||...|.|.|.:     :|:::..::....|..|.
  Fly   247 K--------DEQSSA-----KSLSS---NPAEDEDADEFRID-----DAQLSGGQLAQHFLVDED 290

Human   608 NAVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQN 672
                    ||:|.      :.|..:.:.|:|....|.:.:..:.:|:.|....:|
  Fly   291 --------ESEEG------SDLPAASKVEVSLSSNDDDFDISLPLEQRKPVHSLH---------- 331

Human   673 EMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKE 737
                       |.|                :.:.|||.|   :..|..::||.:| .:...::|.
  Fly   332 -----------EDD----------------ESVDQSLSN---QSTTDDVSELVEE-PVHEMDDKT 365

Human   738 KGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEER 802
            .|:........| :|::.|.|:.::::...|:.........:..:.::|:.        .||::.
  Fly   366 DGSAAISASAPQ-ETQVDESQITDEQDHSMEEIVATNESIEVTYEAEETVN--------TSQKQD 421

Human   803 LIF-LDSIKSKSKDSVWEKEIEILIEEN-----EDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNY 861
            ||. ||.          |.|.::.::..     :.||...:|..:.:|::..|   |.....:..
  Fly   422 LITDLDE----------ESEDQVHVDNRPTSTLQALKLPALQQPQIVERKAAT---ALTTLRLQA 473

Human   862 QELQEEYACLLKVKDD---LEDSKNKQELE-YKSKLKALNEEL---HLQRINPTTVKMKSSVFDE 919
            ..|:.....:|::.||   .:|...:..|: .|.:|.|:|:::   :..:::||         :.
  Fly   474 DVLEPLELTILEMDDDENEEDDDDEESSLQLMKLRLMAMNQQMIVDNAPKLSPT---------EA 529

Human   920 DKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEVKSLK 984
            ::|.|..:....|:.:.:...|.|..:....:..|.|:||..:|..::::....|...:|.|:|.
  Fly   530 EQTQVTSSSNNLEIKQMERVPLTEFSKDVLEDITEESERLLSMSTTMEEEQDPPSLSLDESKTLL 594

Human   985 Q---------EKEQVSLR-CRELEIIIN--HNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSK 1037
            |         ....|||. .::||..:.  |.:.|...:|...::..|:.....:|.|.
  Fly   595 QPGAHKTGGSSSSLVSLNMLKQLEAKVQELHTQLETKDNCLASLNLQLETARRESSAGP------ 653

Human  1038 VNKSFGEESKIMVEDKVSFENMTVGEE------------SKQEQLILDHLPSVTKESSLRATQPS 1090
              .|..:.|.:|..   |.|..|:.||            |::::||.....|:.:..::|
  Fly   654 --ASARDSSSLMTN---STEYRTLQEELGGPTLDIYVEMSRRDELIAKLTDSLQQSLNVR----- 708

Human  1091 ENDKLQKELNVLKSEQNDLRLQME--------------------AQR---ICLSLVYSTHVDQVR 1132
              ||||.:.:.|..|..:||.|::                    .||   |.:.|:..:..|..|
  Fly   709 --DKLQVDADRLGGEVQNLRRQLQETLDAVKRSSAVWPDQECNPGQRISEISMDLISESDDDLDR 771

Human  1133 EYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSE 1197
            .::.:.:::...|.|       |.::.:||...:|.||....:.|           ....|.:.:
  Fly   772 HFLTDNEERGSRSSK-------ERQLTQLQTNEELGLQASNPEWT-----------PTFSKQIEQ 818

Human  1198 ECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQDFQENMHTLLNK 1262
            ..:|.|.|                                          |.:.||        .
  Fly   819 FHTYLLPT------------------------------------------EQRIFQ--------M 833

Human  1263 VTEEYNKLLVLQTRLSKIWGQQTDGMKL---EFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSK 1324
            |..:::..|..|..|.:..|.|.  :|:   ::..|.|..|:.:..:...||   ||:....:.|
  Fly   834 VQRKFDDYLNQQITLCRDLGAQE--LKIARDQWESEKLTSEQNQQAAHAKQM---EDLRKYFEHK 893

Human  1325 LSSLQ-----DLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSL 1384
            .:.|:     |:...|.:.|..:..|..|.:.|..:|......::....:||.:|  |..:.||
  Fly   894 CADLEKQFSDDVFSHKSQHQTGDSSSECSEVDQLPEEGAAAVSSKEPSPRKRKRA--ELLLSPS- 955

Human  1385 PVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQL-------EE 1442
                        .|.|.|  |   .:|...|.:|: ..|:.|..:..|:..||..:       |:
  Fly   956 ------------HRQMTP--C---GLDSLGENTGK-TEKDNTADIADLKIFYQTHIKELKRAHED 1002

Human  1443 EVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLS-----QDQIGFQT 1502
            :|.|  :|..|.|.:     |..|..:...:::.....|..::........|     :|::.|..
  Fly  1003 QVRK--LSDRIKFYE-----RQQGDDDYKPATESPERTCPDQESAGGVANTSLIIIDEDELNFNN 1060

Human  1503 FETVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHD 1567
            ...|..:..||::   |.|.|   ::.|:..|             |:.|:..:.|:.:...::.|
  Fly  1061 ESQVIQRIIEEYE---KRLQE---QLALARQD-------------IATELEQQIKSLLSENTVDD 1106

Human  1568 EISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKR 1632
            :.....:...|:....:.|||                   :.|.:::..|.....:.:.::::.|
  Fly  1107 QHWPKELILLREKFTAKSQLE-------------------ITQLNIKHAEEMSRLKLEFEKQLNR 1152

Human  1633 LN-RQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLC--------CELRNSSTQTQNG 1688
            .| |.|...::.|.|.::.||        :.|::||.:.|..||        ||...::|.::
  Fly  1153 KNKRHLTFDAARDLEQVICER--------DGLRELSKSFRSVLCRLAKCVAHCEEDLNATLSE-- 1207

Human  1689 NENQGEVEEQTFKEKELDRKPEDVPPEI---LSNERYALQKANNRLLKILLEVVKTTAAVEETIG 1750
                 ||:...|..:..| ..:|:...|   |:|.::.|:..:   :..|||||:..:.|:
  Fly  1208 -----EVQRLLFHSRSQD-GGDDLEATISSSLNNTKHMLRVPD---VHSLLEVVEDPSLVQ---- 1259

Human  1751 RHVLGILDRSSKSQSSASL-----IWRSEAEAS----VKSCVHEEHTRVTDESIPSYSGSDMPRN 1806
                 .:|..|..:.|...     :.|.::|||    :...:|::.|.  |||
  Fly  1260 -----FIDSKSNEEPSEDFDLNDCLERLKSEASYLLHLSEDLHKQRTH--DES------------ 1305

Human  1807 DINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHA 1871
                           |:.|........|:..|.|:.:....:..|..:.|.|...|....|:..|
  Fly  1306 ---------------SEHLDEPEKQEHELCCEAEDGLKTTGAVNQQVLSKFLRTNSLNDQQMGVA 1355

Human  1872 KVTQTELMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEG-VIDGYADEKTLFE 1935
            .           ::|....|:.|....|...|.|.:....:|:.:|.:.:. :|...||.:.| :
  Fly  1356 N-----------QRKNSNPEAGKTHSSLPPDLQEHAGNASELSFQLVQLKNRLIKSEADRQNL-Q 1408

Human  1936 RQIQEKTDIIDRLEQELLCASNRLQELEA-------------------EQQQIQEERELLSRQKE 1981
            :|:....|....|.|||....::|.:|.:                   ||...|.....|:.|:.
  Fly  1409 QQLSRTIDRNAELGQELQALRDQLSQLNSLNHTDYNEGYGLGTMKSLQEQGLDQSSASFLALQER 1473

Human  1982 AMK-AEAGPVEQQ-----------LLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQV 2034
            |.. ..:.||::|           |||..|...:|..:|...::|.|:|||.|:
  Fly  1474 ARHLLSSSPVKEQPSRDHGNSTVILLQMIEDFCREGDKVVEFSKKDREDLQSQI----------- 1527

Human  2035 SRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPR 2099
                                 ...:|||:..|:||::||.:||.|||.||:||::|:.||:
  Fly  1528 ---------------------DTADKQLKDTRRFLEDQAAEREQERDEFQREIERLKAQLR---- 1567

Human  2100 FQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSA 2164
                                           .||:........:||..:||.:.||:.|.|..|
  Fly  1568 -------------------------------DKEKEHSSYANASEEYAQLESQFREVNQQLCES- 1600

Human  2165 DTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQL 2229
                           .||.: ..||:|:|..|.|....:.|:.||.|:     :.:..||||
  Fly  1601 ---------------NAKRD-KFEVELKASIDKIFVLREIISELETQV-----QTKALNEEV--- 1641

Human  2230 HMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEI 2294
                      ...:.|:||          |.:.|.::::|.:. |:.|.|.....:..|.:   |
  Fly  1642 ----------LAEKAQQLE----------EYVSLQMRDNDILQ-QEVHSLKTDIGEGYQSR---I 1682

Human  2295 DQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKL 2359
            ..|.|   ||:|.........|:.:..|.:||:||                  .::|..:.:|.|
  Fly  1683 RVLEE---KLKQSGPTAEQGVVLSQVAEKLRDIET------------------TLDQKTKALESL 1726

Human  2360 QQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMN 2424
            ....|      :.|:.|||...|...|                  .::|.|
  Fly  1727 HNSNA------TSNSASLSVTEDVSIH------------------GSKEPT-------------- 1753

Human  2425 QLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSFEEN 2489
                .:.|......:||.:|.:.|             |.:....:.|.|:|.:
  Fly  1754 ----AVGSPSHPSLTVEGVQRVTE-------------KLDRHTRVEEAAIKRI------------ 1789

Human  2490 GKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKIVEEKVAAA 2554
                                 :|||:     |:..|: .|..|   ||.:...||..:||:....
  Fly  1790 ---------------------RDLEM-----QVHQMR-AGCVE---LQHERDTLQGRMEEQTQRI 1824

Human  2555 LVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMH 2619
            ...|.:||..::.|:          :..||...:||               .|:.||:.:|..::
  Fly  1825 STLQNRLEEQRQRAE----------QLHRTGTSDLN---------------TRVHELQGEVQNLY 1864

Human  2620 TSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEE 2684
                   ||:...:|.:....::|                   :||.:::..|:|..|: .:..:
  Fly  1865 -------EQLAARDKQMANMRQQL-------------------QRSKEEITRLETEVEV-RTQPD 1902

Human  2685 SGFFNELEALRAESVATKAELASYKEKAEKLQEELL-------VKETNMTSLQKDLSQVRDHLAE 2742
            ....|:|:   ||.....||:...|   :|::.|::       :.||.:.....::..:||.| |
  Fly  1903 RSLVNKLQ---AEVQQKGAEIVKLK---DKIRTEMINRLAIPDLMETMLADKNDEIDHLRDQL-E 1960

Human  2743 AKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQIN 2807
            ||||          |:|.|::.              |||      |||.:..       ||.|..
  Fly  1961 AKEK----------ELQASQQE--------------ASQ------ISSPSGA-------AGKQEG 1988

Human  2808 LQSECSSEEVTEI--ISQFTEKIEKMQELHAAEILDMESRHISETETLKREHYVAVQLLKEECGT 2870
            ...:.|:..:::|  |::|.|.             |:|.|
  Fly  1989 SGGKLSARTLSDIGSITEFPEP-------------DVERR------------------------- 2015

Human  2871 LKAVIQCLRSKEGSSIPELAHSDAYQTREICSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESA 2935
                 ..:||.....:.|.|....:||.| .|.::.::      |||.:..|::    |......
  Fly  2016 -----AAMRSLTALQMSEGAGGFLHQTME-TSKEAVAN------LTHKRTDDLS----GFIVPYP 2064

Human  2936 TDSFPKKIKGLLRAVHNEGMQVLSLTESPYSDGEDHSIQQVSEPWLEERKAYINTISSLKDLITK 3000
            .::|.          |....|.|.:| :..:||        ..|.|..|:...:.::....|.|.
  Fly  2065 VNTFE----------HPHYFQALGVT-AQSTDG--------LTPGLVPRQINFSNLTEDSKLKTT 2110

Human  3001 MQLQREAEVYDSSQSHESFSDWRGELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLE 3065
            ..|....|:...:...|                 :.:..|.|:..:||.
  Fly  2111 SLLMHTPELPRPTTPPE-----------------IHQLRVKLSDLQTEK---------------- 2142

Human  3066 QRIQEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQ 3130
               |.|..|.:..::.|||                        :.|||.||.|::  ...:|..:
  Fly  2143 ---QRQQSELEKKLQDLQK------------------------ELEQEKEKLSRQ--AQTLQSYE 2178

Human  3131 SQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLE 3195
            ....:.::.:.:::.:..|...|.:|::   ..|:.||.......|....|.....:|||....|
  Fly  2179 ESEAKYRLRIENLESKVLETAAQAASDR---ENLRKELNCVSAAHEQCENAAAARKRELEKLNSE 2240

Human  3196 VKDKTDEVH----------------------LLNDTLASEQKKSRELQWALEKEKAKLGRSEERD 3238
            ||.|.|::|                      |.|...:|:|....|:...:|||   |..|.:.|
  Fly  2241 VKVKADQLHAALRRCADLELQVLTLERDLERLKNSDNSSKQYSVDEIAQQVEKE---LNYSAQLD 2302

Human  3239 KEELEDLKFSLESQKQRNLQLNLLLEQ-----------------QKQLLNE-----SQQKIESQR 3281
            ...|:.::...|:...:.||..:..|:                 :::|||:     :|..:|.::
  Fly  2303 SNILKAIESEEENNLDKKLQKGVQTEEETLPGTGNGTDDENFTGERELLNQLEALRAQLAVEREQ 2367

Human  3282 MLYDAQLSEEQGRNLELQVLLESEKVRI----REMSSTLDRERELHAQLQSSDGTGQSRPPLPSE 3342
            .  :|...|..|.....|.:.|.:.:.|    :.:.:.||.|.|||.||.      |.|
  Fly  2368 C--EAMSKELLGEKQHSQDIQEQDVIIIEAMRKRLETALDAEDELHKQLD------QER------ 2418

Human  3343 DLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHE 3407
            :..:.||.||..        |...|..:..||..:...:..|:..|...::|.......:.|:..
  Fly  2419 ERCERLQTQLTS--------LQRAESRRNSSLLLKSPGDSPRKSPRADFESELGDRLRSEIKLLV 2475

Human  3408 LQSKVE-----DLQRQLEEKRQQVYKLDLEG-----QRLQGIMQEFQKQELER-EEKRESRRILY 3461
            .|::.|     |.||..|.:||: |:.:|:.     :||        |||:|: ...:||.....
  Fly  2476 AQNERERERSADAQRSSERERQR-YEKELQERVAYCERL--------KQEMEKLSRDKESAETEL 2531

Human  3462 QNLNEPTTW---SLTSDRTRNWVLQQKIEGETKESNYAKLIEMNGGGTGCNHELEMIRQKLQCVA 3523
            ::.||..|.   .:.|...|...||   |.||:.:|           |......|.:  |||...
  Fly  2532 EHFNERLTLQASEIESLEARLVTLQ---EAETRRAN-----------TRTRQHQENV--KLQAEI 2580

Human  3524 SKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQKLTGQQGEEPSLVSPSTSCGSLTERL 3588
            .:|:      |:.|..|.|.|        .:|:.:.||:....:.|:..:         .|.|.|
  Fly  2581 HELK------SKLLAAEAARD--------CLDQKVTQLRFDVSRSGQREA---------KLAEAL 2622

Human  3589 LRQNAELTGHISQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKE 3653
            .:.|..| .|    :.:.|.....:.|::|                         |.|::| |..
  Fly  2623 AQANDRL-AH----STDDNVPAQFMQKMKE-------------------------INALLA-ENT 2656

Human  3654 VWNR-----------EKLTLQKSLKR----AEAEVYKLKAELRNDSLLQTLSPDSEHVTLKRIYG 3703
            ..||           |::.|||..:.    ....|.:|:...|                  ::.|
  Fly  2657 QENRQMAETVQFLVGERIALQKKCEELGGAGNTNVTELEERCR------------------QLIG 2703

Human  3704 KYLRAESFRKALIYQKKYLLLLLGGFQECEDATLALLARMGG--QPAFTDLEVITNRPKGFTRFR 3766
            :|||.||.||||:|||:||.|.|.|:|..|.  |||....||  ||...:::         .:|:
  Fly  2704 RYLRVESHRKALVYQKRYLKLTLEGYQASEQ--LALQNLRGGAEQPPQRNIK---------KKFK 2757

Human  3767 SAVRVSIAISRMKFLVRRWHRVTGSVSININRDGFGLNQGAEKTDSFYHSSGGLELYGEPRHTTY 3831
            :.....|||.|:|::.|.||.....||.::    |.:.|         ..|.||.|...|.
  Fly  2758 TVALAIIAIQRIKYIGRIWHTGKRIVSKSV----FTITQ---------QRSPGLNLNVAPP---- 2805

Human  3832 RSRSDLDYIRSPLPFQN 3848
                     :||||..|
  Fly  2806 ---------QSPLPGPN 2813

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AKAP9	NP_005742.4	PKA-RII subunit binding domain	2542..2555		4/12 (33%)
		Smc	<3066..>3365	CDD:440809	72/346 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3377..3405		3/27 (11%)
		PACT_coil_coil	3704..3785	CDD:463115	33/82 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..57
		EnvC	161..>366	CDD:443969
		SMC_prok_B	277..>1006	CDD:274008	126/682 (18%)
		Smc	<1576..>2095	CDD:440809	121/571 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1682..1713		6/30 (20%)
		SMC_prok_B	<2029..2432	CDD:274008	81/402 (20%)
		SMC_N	2200..>2874	CDD:481474	124/682 (18%)
Plp	NP_001027574.2	EnvC	1375..>1606	CDD:443969	70/315 (22%)
		SMC_prok_B	1517..2569	CDD:274008	310/1567 (20%)
		GumC	<2465..>2676	CDD:442439	61/289 (21%)
		PACT_coil_coil	2704..2776	CDD:463115	33/82 (40%)