DRSC/TRiP Functional Genomics Resources

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Protein Alignment TOB1 and Tob

DIOPT Version :10

Sequence 1:NP_005740.1 Gene:TOB1 / 10140 HGNCID:11979 Length:345 Species:Homo sapiens
Sequence 2:NP_573104.1 Gene:Tob / 32574 FlyBaseID:FBgn0028397 Length:564 Species:Drosophila melanogaster


Alignment Length:444 Identity:160/444 - (36%)
Similarity:212/444 - (47%) Gaps:126/444 - (28%)


- Green bases have known domain annotations that are detailed below.


Human     1 MQLEIQVALNFIISYLYNKLPRRRVNIFGEELERLLKKKYEGHWYPEKPYKGSGFRCIHIGEKVD 65
            |.:||||||||:|||||||||||||||||||||:.|:.|::.|||||||:|||.:||:..|:.:|
  Fly     1 MHIEIQVALNFVISYLYNKLPRRRVNIFGEELEKALRDKFQDHWYPEKPFKGSAYRCLKTGDPID 65

Human    66 PVIEQASKESGLDIDDVRGNLPQDLSVWIDPFEVSYQIGEKGPVKVLYVD--DNNENGCELDKEI 128
            .|:|:|::|||:.|.|:..|||.:|||||||.|||::|||||.||:||.:  :|:|:....|:|:
  Fly    66 SVLERAARESGVPIGDILENLPNELSVWIDPGEVSFRIGEKGAVKILYTENNENHEDSHSADREV 130

Human   129 KNSFNPEAQVFMPI---------------------SDPASSVSSSPS------------------ 154
            ...||||||.|.||                     |.|.|:.||||:                  
  Fly   131 TKMFNPEAQCFRPIDAVNTTMNNMSLSPKGHHQSGSSPHSAASSSPTYKGSPNRTISGSCSSVSG 195

Human   155 ------------------------PPFGHSA---AVSPTFMPRSTQ-PLTFTTATFAATKFGSTK 191
                                    |..|:.|   |.:..||.|..| ||||||||||.|||||||
  Fly   196 AGSGTGSGSRSGSNHAPGPGTAPGPVPGNGATANAAAAAFMQRGAQAPLTFTTATFAQTKFGSTK 260

Human   192 MKNSGR---SNKVARTSPINLGLNVNDLLKQKAISSSMHSLYGL--GLGSQQQPQQQQQPAQPPP 251
            :|.|.:   |:...|.||...    ::.:||:|:...||..:.:  ..||..........|..|.
  Fly   261 LKTSSKRTNSSSAYRMSPTEF----SNYIKQRAMQQQMHHGHAVVPSAGSSVSAAYGGMDAVSPA 321

Human   252 ---PPPPPQQQQQQKTSALSPNAKEFIFPNMQGQGSSTNGMFPGDSPLNLSPLQYSNAFDVFAAY 313
               .|.|......|..|....:|..:.:|||               |:|:.| ||.|...:|.::
  Fly   322 RSLSPNPLSLAGNQNQSVSGSSADSYYYPNM---------------PINMYP-QYGNPRCLFESH 370

Human   314 GGLNEKS---FVDGL--------------------------NFSLNNMQYSNQQ 338
            ...:..|   :|.|.                          |...|..|:|.||
  Fly   371 FSADVSSMGLYVSGTAGAAVTAVGSVGANKYSTYLEPCYYGNGHANTQQHSQQQ 424

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TOB1NP_005740.1 btg1 1..106 CDD:128410 69/104 (66%)
Bipartite nuclear localization signal. /evidence=ECO:0000250 22..39 13/16 (81%)
Important for nuclear localization. /evidence=ECO:0000250 82..92 4/9 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 144..171 12/71 (17%)
Required for interaction with CPEB3. /evidence=ECO:0000269|PubMed:21336257 161..218 29/63 (46%)
Nuclear export signal. /evidence=ECO:0000250 226..234 2/9 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 231..267 8/40 (20%)
TobNP_573104.1 BTG 1..113 CDD:462251 74/111 (67%)

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