Protein Alignment OPTN and Optn

DIOPT Version :10

• Sequence 1: NP_068815.2
• Gene: OPTN / 10133
• HGNCID: 17142
• Length: 577
• Species: Homo sapiens
• Sequence 2: NP_862896.1
• Gene: Optn / 71648
• MGIID: 1918898
• Length: 584
• Species: Mus musculus
• Alignment Length: 593
• Identity: 456/593 - (76%)
• Similarity: 504/593 - (84%)
• Gaps: 25/593 - (4%)

Human     1 MSHQPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKLNNQAM 65
            ||||||||||||.|||.|:.||||.::.||:|||||||||||||||||.||||||||||||||||
Mouse     1 MSHQPLSCLTEKGDSPCETPGNGPSNMVHPSLDTFTPEELLQQMKELLVENHQLKEAMKLNNQAM 65

Human    66 KGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSR 130
            ||||||||||||||||||..||:||||.||||.||:||||:|||||||.|.|||:..||.|...|
Mouse    66 KGRFEELSAWTEKQKEERLLFEMQSKEVKERLKALTHENERLKEELGKFKEKSEKPLEDLTGGYR 130

Human   131 LPRA----------EAEQEKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAE 185
            .|||          :.|||.:.|:.||:||:|||||||||||||||||||.||||||||||||.|
Mouse   131 YPRALEEEVEKLKTQVEQEVEHLKIQVMRLRAEKADLLGIVSELQLKLNSGGSSEDSFVEIRMTE 195

Human   186 GEAEGSVKEIKHSPGPTRT--VSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVE 248
            ||.||::||:|:.|.||||  :|.        |...:.|::..|.||||||||||||||||||||
Mouse   196 GETEGAMKEMKNCPTPTRTDPISL--------SNCTEDARSCAEFEELTVSQLLLCLREGNQKVE 252

Human   249 RLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKEL 313
            ||||||:|||||:||||||.:..|..|.||....::|. |:||.|:||||||.|::|||||||||
Mouse   253 RLEVALREAKERISDFEKKANGHSSTEKQTARRADREK-EDKGQESVGSEVETLSIQVTSLFKEL 316

Human   314 QEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAK 378
            ||||||||||||||||||||||||||||||.||||||||||||:|||||||||||.|||||||||
Mouse   317 QEAHTKLSEAELMKKRLQEKCQALERKNSATPSELNEKQELVYSNKKLELQVESMRSEIKMEQAK 381

Human   379 TEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQLQ 443
            ||:|||:|..||.||||||||||.|||||||||::::||||:.:|:||||||||||:||||||||
Mouse   382 TEEEKSRLATLQATHNKLLQEHNKALKTIEELTKQQAEKVDKMLLQELSEKLELAEQALASKQLQ 446

Human   444 MDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLLKENDAFED 508
            |||||||:||||||||||.:||||||||||||||||||||||||||||||||||:|||||:..|:
Mouse   447 MDEMKQTLAKQEEDLETMAVLRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAILLKENNDIEE 511

Human   509 GG-RQSLMEMQSRHGARTSDSDQQAYLVQRGAEDRDW---RQQRNIPIHSCPKCGEVLPDIDTLQ 569
            || ||||||||.||||||||||||.||.|||||||.|   :|.|:||||||||||||||||||||
Mouse   512 GGSRQSLMEMQCRHGARTSDSDQQTYLFQRGAEDRSWQHGQQPRSIPIHSCPKCGEVLPDIDTLQ 576

Human   570 IHVMDCII 577
            ||||||||
Mouse   577 IHVMDCII 584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OPTN	NP_068815.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..32		22/30 (73%)
		NEMO	37..103	CDD:431942	58/65 (89%)
		Interaction with Rab8	58..209		113/162 (70%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	101..143		25/51 (49%)
		LIR	176..181		4/4 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	186..209		13/24 (54%)
		SMC_prok_B	245..>520	CDD:274008	225/275 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	261..297		16/35 (46%)
		CC2-LZ	408..507	CDD:465155	83/98 (85%)
		Interaction with HD	411..577		141/169 (83%)
		Interaction with MYO6. /evidence=ECO:0000269|PubMed:15837803	412..520		90/108 (83%)
		UBAN	474..479		4/4 (100%)
		zf_C2H2_10	551..576	CDD:436483	24/24 (100%)
Optn	NP_862896.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..32		22/30 (73%)
		NEMO	37..103	CDD:431942	58/65 (89%)
		Interaction with Rab8. /evidence=ECO:0000250	58..219		112/160 (70%)
		LIR	186..191		4/4 (100%)
		Smc	<224..>472	CDD:440809	197/248 (79%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	267..302		17/35 (49%)
		CC2-LZ	411..507	CDD:465155	82/95 (86%)
		Interaction with HD. /evidence=ECO:0000250	414..584		141/169 (83%)
		Interaction with MYO6. /evidence=ECO:0000250|UniProtKB:Q96CV9	415..524		90/108 (83%)
		UBAN	477..482		4/4 (100%)
		zf_C2H2_10	558..583	CDD:436483	24/24 (100%)