DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment OPTN and key

DIOPT Version :10

Sequence 1:NP_068815.2 Gene:OPTN / 10133 HGNCID:17142 Length:577 Species:Homo sapiens
Sequence 2:NP_001246503.1 Gene:key / 37967 FlyBaseID:FBgn0041205 Length:389 Species:Drosophila melanogaster


Alignment Length:475 Identity:94/475 - (19%)
Similarity:171/475 - (36%) Gaps:161/475 - (33%)


- Green bases have known domain annotations that are detailed below.


Human   173 SSEDSFVEIRMA-----------EGEAEGSVKEIKHSPGPTRT-------VSTGTALSKYRSRSA 219
            |.|:|||.:..:           ..:..|:.:|.|.:...|.|       :......|:.:.:|.
  Fly     2 SDEESFVILGSSPCSSLMPDSSLRSDVCGNAQEAKETVASTSTQPPTVNCIPVSITASQQQHKSL 66

Human   220 DGAKNYFEHEELTVSQLL------------------LCLREGN-QKVERLE------VALKEAKE 259
            |...:  :.:.|..|.::                  ||..:|: ::|.:|:      :|||...:
  Fly    67 DSGSS--QQQSLATSFIMGEIQSDVLKNSVYSQFPSLCSLQGSAEEVVKLQNMMTEYLALKSTLD 129

Human   260 RVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAE 324
            :|:.......|.::...|.....|.:..|         .|:....|:..|..|.||         
  Fly   130 KVNQTMLNYHNLTQQWRQEAADREHQYKE---------HVKECQAQIAILRVENQE--------- 176

Human   325 LMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVL 389
             :|:.|:.|.:.:|..::.   .|.|:.||    :|...:.:|::..:::|..|           
  Fly   177 -LKRDLETKIEQIEGVHTI---RLKEQDEL----RKSVSEKQSLIDNMRVEIDK----------- 222

Human   390 QMTHNKLLQEHNNALKTIEE-LTRKESEKVDRAVLKELSEKLELAEKALASKQLQMDEMKQTIAK 453
                   |::.|::.:.:.| .|..:|:        ||.:|::|....|.::.:|    ||.:.|
  Fly   223 -------LKQLNHSFEFVPEYATESKSQ--------ELIKKMQLDINELKARDIQ----KQEVIK 268

Human   454 QEEDLETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLLKENDAFED---------- 508
            .         |:.|.::|..||..|||.|||...||:|..:.|..|.:.|....:          
  Fly   269 G---------LQIQNDIYRRDFEMERADREKNAGEKDQYLMDLRSLQRRNQELIEALAESHKASK 324

Human   509 ---------GGRQSLMEMQ--------SRHGARTSDSDQQAYLVQRGAEDRDWRQQRNIPIHSCP 556
                     ..|.:|.|.|        :...:||||:..:                       ||
  Fly   325 ACSTASPLSSSRSNLREEQRPVRILDPTGASSRTSDTTLR-----------------------CP 366

Human   557 KCGEVLPDIDTLQIHVMDCI 576
            .|.:....:..||.||.||:
  Fly   367 ICSKSFNALSVLQSHVNDCL 386

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
OPTNNP_068815.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..32
NEMO 37..103 CDD:431942
Interaction with Rab8 58..209 10/53 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 101..143
LIR 176..181 3/4 (75%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 186..209 5/29 (17%)
SMC_prok_B 245..>520 CDD:274008 63/308 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 261..297 5/35 (14%)
CC2-LZ 408..507 CDD:465155 29/99 (29%)
Interaction with HD 411..577 45/193 (23%)
Interaction with MYO6. /evidence=ECO:0000269|PubMed:15837803 412..520 31/134 (23%)
UBAN 474..479 2/4 (50%)
zf_C2H2_10 551..576 CDD:436483 8/24 (33%)
keyNP_001246503.1 Smc <120..>318 CDD:440809 57/262 (22%)
UBAN 230..313 CDD:197361 29/103 (28%)
Blue background indicates that the domain is not in the aligned region.

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