DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment OPTN and optn

DIOPT Version :10

Sequence 1:NP_068815.2 Gene:OPTN / 10133 HGNCID:17142 Length:577 Species:Homo sapiens
Sequence 2:NP_001093536.2 Gene:optn / 336159 ZFINID:ZDB-GENE-030131-8103 Length:524 Species:Danio rerio


Alignment Length:586 Identity:235/586 - (40%)
Similarity:336/586 - (57%) Gaps:99/586 - (16%)


- Green bases have known domain annotations that are detailed below.


Human    17 SESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWTEKQKE 81
            |...|:||.:|.       :.||.||||..|:.||..||||:|..|.:||.|||.||||.|||||
Zfish    13 SHPRGSGPGNLG-------SLEETLQQMNTLIKENRDLKEALKQTNLSMKERFEGLSAWKEKQKE 70

Human    82 ERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLPRAEA-EQEKDQLRT 145
            ||.|.|.:.:||:.||..:..|||.||.::.:|    |:|.           ||. ..|.:.||.
Zfish    71 ERDFLEQRLEEARTRLNTMDVENEALKNQVKEL----EKSG-----------AECLHTELEALRG 120

Human   146 QVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTRTVSTGTA 210
            |::|:||||.||:.:.||||||: ..||..:||:|||:|:.:.:           .|:.:|:...
Zfish   121 QILRIQAEKNDLVAMNSELQLKM-GQGSPSNSFIEIRIADDDLK-----------VTKDLSSVPE 173

Human   211 LSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKKTSNR-SEI 274
            .|.:....|       |.||.||.|||..||....:.|||::.|:||:.|:::.|.|..:. |..
Zfish   174 ASAFSMPKA-------ESEEQTVRQLLRSLRAETDEKERLQLTLQEARGRIAELESKLEHADSSA 231

Human   275 ET------QTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEK 333
            :|      :|..|||.:|.|:               |:..|..||::|..||.|||.||:.||::
Zfish   232 QTSLPSAAETNASTEVKNLED---------------QLLKLCNELKQAQIKLDEAESMKRNLQDR 281

Human   334 CQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQMTHNKLLQ 398
            |:.||:....:.::|.:||::...|..|::|:||:.:.||:||.||:|||:.|..|:..:.||.:
Zfish   282 CKDLEQDLGTLKTQLGDKQKVQAENDCLKVQMESLQAAIKLEQKKTQDEKNNLNQLKDAYTKLFE 346

Human   399 EHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEEDLETMTI 463
            :::.    ::|..:|....|.:....||..:...||||||.||.::||||..:.::|:||||:::
Zfish   347 DYSE----LQEEKKKRESCVSKDDYDELQTRFATAEKALADKQQKIDEMKMELFQKEKDLETISV 407

Human   464 LRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLLKEN----DAFEDGGRQSLMEMQSRHGAR 524
            .:||.|:|.|||:||||||||||||||:||.||..:.|:|    :..|..||.|:.|||.||   
Zfish   408 FQAQAEIYSSDFYAERAAREKIHEEKERLATQLEYVKKQNSQLQEEMESLGRHSMSEMQRRH--- 469

Human   525 TSDSDQQAYLVQRGAEDR-------------DWRQQRNIPIHSCPKCGEVLPDIDTLQIHVMDCI 576
                      |.|||..:             :| ||:|||.|:||||||||||:|:||||:||||
Zfish   470 ----------VPRGANPQGPTAPNNLPGGRGEW-QQQNIPDHACPKCGEVLPDLDSLQIHIMDCI 523

Human   577 I 577
            |
Zfish   524 I 524

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
OPTNNP_068815.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..32 5/14 (36%)
NEMO 37..103 CDD:431942 37/65 (57%)
Interaction with Rab8 58..209 61/151 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 101..143 11/42 (26%)
LIR 176..181 2/4 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 186..209 2/22 (9%)
SMC_prok_B 245..>520 CDD:274008 111/285 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 261..297 10/42 (24%)
CC2-LZ 408..507 CDD:465155 49/102 (48%)
Interaction with HD 411..577 86/182 (47%)
Interaction with MYO6. /evidence=ECO:0000269|PubMed:15837803 412..520 55/111 (50%)
UBAN 474..479 3/4 (75%)
zf_C2H2_10 551..576 CDD:436483 19/24 (79%)
optnNP_001093536.2 NEMO 27..92 CDD:431942 37/64 (58%)
SMC_prok_B <90..468 CDD:274008 160/430 (37%)
CC2-LZ 353..451 CDD:465155 49/97 (51%)
zf_C2H2_10 498..523 CDD:436483 19/24 (79%)

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