DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment OPTN and Optn

DIOPT Version :10

Sequence 1:NP_068815.2 Gene:OPTN / 10133 HGNCID:17142 Length:577 Species:Homo sapiens
Sequence 2:XP_063132130.1 Gene:Optn / 246294 RGDID:628886 Length:662 Species:Rattus norvegicus


Alignment Length:671 Identity:469/671 - (69%)
Similarity:512/671 - (76%) Gaps:103/671 - (15%)


- Green bases have known domain annotations that are detailed below.


Human     1 MSHQPLSCLTEKEDSPSESTGNGPPHLAHPNLDTFTPEELLQQMKELLTENHQLKEAMKLNNQAM 65
            ||||||||||||.||..|:.||||.::.||||||||||||||||||||.||||||||||||||||
  Rat     1 MSHQPLSCLTEKGDSSCETPGNGPSNMVHPNLDTFTPEELLQQMKELLVENHQLKEAMKLNNQAM 65

Human    66 KGRFEELSAWTEKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSR 130
            |||||||||||||||||||.||||||||||||.|||||||:|||||||||.||||..||.|....
  Rat    66 KGRFEELSAWTEKQKEERQLFEIQSKEAKERLKALSHENERLKEELGKLKEKSERPFEDITGRCG 130

Human   131 LPRAEAEQEKDQ-----------LRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMA 184
            .||.:.|||.:|           |:.||.|||||||||||||||||||||||||||||||||||.
  Rat   131 FPRTDLEQEVEQLKRQVEQEVEHLKNQVRRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMT 195

Human   185 EGEAEGSVKEIKHSPGPTRT--VSTGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKV 247
            ||||||::||:::|.|||||  :|.|        :..:.|:...|.|||||||||||||||||||
  Rat   196 EGEAEGAMKEMRNSAGPTRTDSISMG--------KCTEDARTCVEFEELTVSQLLLCLREGNQKV 252

Human   248 ERLEVALKEAKERVSDFEKKTSNRSEIETQTEGSTEKENDEEKGPETVGSEVEALNLQVTSLFKE 312
            ||||:||:|||||:||||||.:..|.|||||||||:|| :|:|.||:||.|||.||:||.|||||
  Rat   253 ERLEIALREAKERISDFEKKANGHSAIETQTEGSTQKE-EEDKDPESVGIEVETLNVQVASLFKE 316

Human   313 LQEAHTKLSEAELMKKRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQA 377
            |||||||||||||||||||||||||||||||.||||||||||||:|:|||||||||.||||||||
  Rat   317 LQEAHTKLSEAELMKKRLQEKCQALERKNSATPSELNEKQELVYSNRKLELQVESMRSEIKMEQA 381

Human   378 KTEDEKSKLTVLQMTHNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQL 442
            |||:|||:|..||.||:|||||||.||:||||||::::||||:..|:||||||||||:|||||||
  Rat   382 KTEEEKSRLATLQATHDKLLQEHNKALRTIEELTKQQAEKVDKVQLQELSEKLELAEQALASKQL 446

Human   443 QMDEMKQTIAKQEEDLETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLLKENDAFE 507
            |||||||||||||||||||.:||||||||||||||||||||||||||||||||||:|||||:.||
  Rat   447 QMDEMKQTIAKQEEDLETMAVLRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAILLKENNDFE 511

Human   508 DG--------------------------------------------------------------- 509
            ||                                                               
  Rat   512 DGGRCGCGRLPQSVYGDHRTGVSSLPQSVYGDHRTGVSSLPQSVYGDHRTGVSSLPHSVYGDHRT 576

Human   510 ---------------GRQSLMEMQSRHGARTSDSDQQAYLVQRGAEDRDW---RQQRNIPIHSCP 556
                           |||||||||.|||||||||||||||.||||||..|   :|.|:|||||||
  Rat   577 GVSSLPHSVYGDHRTGRQSLMEMQCRHGARTSDSDQQAYLFQRGAEDMSWQHGQQPRSIPIHSCP 641

Human   557 KCGEVLPDIDTLQIHVMDCII 577
            |||||||||||||||||||||
  Rat   642 KCGEVLPDIDTLQIHVMDCII 662

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
OPTNNP_068815.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..32 21/30 (70%)
NEMO 37..103 CDD:431942 62/65 (95%)
Interaction with Rab8 58..209 121/163 (74%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 101..143 27/52 (52%)
LIR 176..181 4/4 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 186..209 14/24 (58%)
SMC_prok_B 245..>520 CDD:274008 230/352 (65%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 261..297 23/35 (66%)
CC2-LZ 408..507 CDD:465155 84/98 (86%)
Interaction with HD 411..577 144/246 (59%)
Interaction with MYO6. /evidence=ECO:0000269|PubMed:15837803 412..520 93/185 (50%)
UBAN 474..479 4/4 (100%)
zf_C2H2_10 551..576 CDD:436483 24/24 (100%)
OptnXP_063132130.1 None

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