Protein Alignment OPTN and F46H5.7

DIOPT Version :10

• Sequence 1: NP_068815.2
• Gene: OPTN / 10133
• HGNCID: 17142
• Length: 577
• Species: Homo sapiens
• Sequence 2: NP_001360046.1
• Gene: F46H5.7 / 180987
• WormBaseID: WBGene00018522
• Length: 578
• Species: Caenorhabditis elegans
• Alignment Length: 378
• Identity: 89/378 - (23%)
• Similarity: 164/378 - (43%)
• Gaps: 58/378 - (15%)

Human   212 SKYRSRSADGAK--NYFEHEELTVSQLLLCLREG--NQKVERLEVALKEAKERVSDFEKKTSNRS 272
            |::.:..||.:|  :.||.....|.:|......|  :|||      ....|.|.....||...||
 Worm    86 SRHGTHFADYSKANDAFEKNISAVQKLFAAAGLGGRSQKV------YAAGKTRARSTSKKNQPRS 144

Human   273 EIETQTEG---STEKE-NDEEKGPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMKKRLQEK 333
            :.:.|.|.   |.|.| .|.||  |....::|.|..:...|...::|..:.||.|:|..|.|::|
 Worm   145 QFDAQPENVNISEESEGRDSEK--EKNDRQLEKLRNRNDELKIRVKEYKSDLSAAQLKVKNLEKK 207

Human   334 CQAL-----ERKNSAIPSELNEKQELVYTNK--KLELQVESMLSEIKMEQAKTEDEKSKLTVLQM 391
            .::.     |.|...|.||::||:...:..:  .|...:|.:.:::...::|.:|.::|.:
 Worm   208 LESAQSADSEEKFVRIDSEIDEKRSQDHDEEINNLHNVIEELRNKLATVESKNKDLETKFS---- 268

Human   392 THNKLLQEHNNALKTIE--------ELTRKESEKVDRAVLKELSEKLELAEKALASKQLQMDEMK 448
                   |:.:.||..:        :|.....|:|....::.|..||.||..::...:.:..:::
 Worm   269 -------ENQDYLKNAKDKVTFLENQLNSDAHEEVKSTAVRALEVKLGLANNSIRQAEAEKQQLQ 326

Human   449 QT-------IAKQEEDLETMTILRAQMEVYCSDFHAERAARE------KIHEEKEQLALQLAVLL 500
            :.       :.|.|::...:..:..|::......|||:..::      :|:|||.:|..:|..|.
 Worm   327 EANWYANERVGKLEQENGYLKGITEQLKARADTSHAEKMLKDSEKRVWEINEEKSKLEWRLGELS 391

Human   501 K-ENDA-FEDGGRQSLMEMQSRHGARTSDSDQQAYLVQRGAEDRDWRQQRNIP 551
            : .||| ::.|..:|.:.:| |:...|::|..|:...|...|.|.......||
 Worm   392 QWWNDAKWKVGELESSVALQ-RNLLDTANSKIQSLNDQLIQEVRSHSSTMTIP 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OPTN	NP_068815.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..32
		NEMO	37..103	CDD:431942
		Interaction with Rab8	58..209
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	101..143
		LIR	176..181
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	186..209
		SMC_prok_B	245..>520	CDD:274008	71/308 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	261..297		13/39 (33%)
		CC2-LZ	408..507	CDD:465155	24/121 (20%)
		Interaction with HD	411..577		35/156 (22%)
		Interaction with MYO6. /evidence=ECO:0000269|PubMed:15837803	412..520		26/122 (21%)
		UBAN	474..479		2/4 (50%)
		zf_C2H2_10	551..576	CDD:436483	1/1 (100%)
F46H5.7	NP_001360046.1	NTD_TDP-43	17..82	CDD:410991
		SMC_N	<109..444	CDD:481474	83/355 (23%)
		E_set_AMPKbeta_like_N	499..577	CDD:199889