DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment OPTN and optn

DIOPT Version :10

Sequence 1:NP_068815.2 Gene:OPTN / 10133 HGNCID:17142 Length:577 Species:Homo sapiens
Sequence 2:XP_017947825.1 Gene:optn / 100144665 XenbaseID:XB-GENE-943658 Length:538 Species:Xenopus tropicalis


Alignment Length:576 Identity:257/576 - (44%)
Similarity:356/576 - (61%) Gaps:70/576 - (12%)


- Green bases have known domain annotations that are detailed below.


Human    27 LAHPNL------------DTFTPE---ELLQQMKELLTENHQLKEAMKLNNQAMKGRFEELSAWT 76
            |.||::            |.|:.:   |:|:|:|:||.||:.|||.||..||.||.|.|||    
 Frog     6 LKHPHVINMENGHQDASCDVFSMKNDAEMLEQIKQLLMENNNLKETMKQMNQEMKERLEEL---- 66

Human    77 EKQKEERQFFEIQSKEAKERLMALSHENEKLKEELGKLKGKSERSSEDPTDDSRLP---RAEAEQ 138
                         .|...:.|:.|:.|||.|::||..|:.|:..|::.      :|   ..|...
 Frog    67 -------------LKRHNQHLLDLNSENELLRKELNSLREKNATSNQG------IPVCSNPEETS 112

Human   139 EKDQLRTQVVRLQAEKADLLGIVSELQLKLNSSGSSEDSFVEIRMAEGEAEGSVKEIKHSPGPTR 203
            |..||:||::|||||||||||::|||||||  ||.|||||||||::|.|:    .||.|.....:
 Frog   113 ESKQLKTQLMRLQAEKADLLGLISELQLKL--SGFSEDSFVEIRISEKES----GEIIHEEKANK 171

Human   204 TV-STGTALSKYRSRSADGAKNYFEHEELTVSQLLLCLREGNQKVERLEVALKEAKERVSDFEKK 267
            |: ....:.|:..|...:|:..  |.||:.:|:||..|||..|||||||..|.|.| |:::.::|
 Frog   172 TLPDYDVSYSRTNSVKEEGSGT--EPEEVAISRLLRSLREETQKVERLEKELSEHK-RLAELKEK 233

Human   268 TSNRSEIETQTEGSTEKENDEEK-----GPETVGSEVEALNLQVTSLFKELQEAHTKLSEAELMK 327
            ||...:.:.|||  .||:|..|:     ....:.|||:.|..:|.||.|||||.:.||:||:.:|
 Frog   234 TSRFCDKDMQTE--QEKQNQSEEIFLLHAFFQISSEVDILKQKVKSLNKELQETNDKLNEAKQLK 296

Human   328 KRLQEKCQALERKNSAIPSELNEKQELVYTNKKLELQVESMLSEIKMEQAKTEDEKSKLTVLQMT 392
            ..|||||..|:::......:|.|||.|.||.||||||||||.||||:|:.|||.||::|.:||:.
 Frog   297 NSLQEKCILLDKRLQENAVDLEEKQNLRYTIKKLELQVESMESEIKLERNKTEAEKNQLAILQVA 361

Human   393 HNKLLQEHNNALKTIEELTRKESEKVDRAVLKELSEKLELAEKALASKQLQMDEMKQTIAKQEED 457
            ::||..|:       :|...:|||||.:....:|.|||:..|||||.||.::||::|..||.:||
 Frog   362 YDKLNSEY-------QETRIRESEKVSKVEFNDLVEKLDACEKALAKKQFEIDEIRQMDAKHKED 419

Human   458 LETMTILRAQMEVYCSDFHAERAAREKIHEEKEQLALQLAVLLKENDAF--EDGGRQSLMEMQSR 520
            :||:.:||||::|||:||||||:|||.||:|||||..:||.:::|::..  |..||||:.::|.|
 Frog   420 IETIGLLRAQIDVYCADFHAERSARENIHQEKEQLEARLAYMIQESEKLKAEMMGRQSIEQLQRR 484

Human   521 HGARTSDSDQQAYLVQRGAEDRDWRQQRNIPIHSCPKCGEVLPDIDTLQIHVMDCI 576
            |..|..:.....|||.||||:..   |.:|.:::||||...:||||||||||||||
 Frog   485 HSCRLENVSGGPYLVPRGAENMG---QPSITVYTCPKCNLTVPDIDTLQIHVMDCI 537

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
OPTNNP_068815.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..32 3/4 (75%)
NEMO 37..103 CDD:431942 24/68 (35%)
Interaction with Rab8 58..209 64/154 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 101..143 12/44 (27%)
LIR 176..181 4/4 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 186..209 5/23 (22%)
SMC_prok_B 245..>520 CDD:274008 135/281 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 261..297 10/40 (25%)
CC2-LZ 408..507 CDD:465155 52/100 (52%)
Interaction with HD 411..577 87/168 (52%)
Interaction with MYO6. /evidence=ECO:0000269|PubMed:15837803 412..520 57/109 (52%)
UBAN 474..479 4/4 (100%)
zf_C2H2_10 551..576 CDD:436483 16/24 (67%)
optnXP_017947825.1 NEMO 31..97 CDD:431942 32/82 (39%)
SMC_prok_B <194..>412 CDD:274008 105/227 (46%)
CC2-LZ 370..469 CDD:465155 52/98 (53%)
zf_C2H2_10 514..537 CDD:436483 16/22 (73%)

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