DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CDH15 and cdh15

DIOPT Version :9

Sequence 1:	NP_004924.1	Gene:	CDH15 / 1013	HGNCID:	1754	Length:	814	Species:	Homo sapiens
Sequence 2:	NP_997771.2	Gene:	cdh15 / 565617	ZFINID:	ZDB-GENE-030131-780	Length:	792	Species:	Danio rerio

Alignment Length:	778	Identity:	358/778 - (46%)
Similarity:	483/778 - (62%)	Gaps:	42/778 - (5%)

- Green bases have known domain annotations that are detailed below.

Human    28 PTTLYPWRRAPALSRVRRAWVIPPISVSENHKRLPYPLVQIKSDKQQLGSVIYSIQGPGVDEEPR 92
            |..|.|||.     ||:|.|:||||.|.||.|.||..||||||||...|.|||.::|||||::|:
Zfish    29 PAVLNPWRH-----RVKRDWIIPPIRVLENSKHLPEDLVQIKSDKIFTGEVIYMLEGPGVDQDPK 88

Human    93 GVFSIDKFTGKVFLNAMLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFLQEAF 157
            |:|.||:.||.:.....|||||...|:|:||||...|..||.||.:||.|:|||||||.|.|:.|
Zfish    89 GLFEIDEKTGWIKSKEPLDREKHKSFKLKAFALSPSGERLESPTTIEIYVLDQNDNRPEFTQKEF 153

Human   158 TGRVLEGAVPGTYVTRAEATDADDPETDNAALRFSIL-QQGSP------ELFSIDELTGEIRTVQ 215
            .|.:.|.:||||.|.:..|.|.|||.||||||.:||: |:..|      .:|.|:..||.|....
Zfish   154 IGTIPEFSVPGTSVMQVTAVDFDDPSTDNAALSYSIIGQECDPPHGINKTMFGINNKTGVIYIRD 218

Human   216 VGLDREVVAVYNLTLQVADMSGDGLTATASAIITLDDINDNAPEFTRDEFFMEAIEAVSGVDVGR 280
            |||||:||..:.||||||||||.|||:::.|||.:.|||::||:|....:.|.|:|.....:|||
Zfish   219 VGLDRDVVQSFRLTLQVADMSGMGLTSSSRAIIHISDINNHAPKFQPTTYNMYAMENKLIAEVGR 283

Human   281 LEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYESCEHYELKVSVQNE 345
            :...|:|..|..||..::||:  :|.|.|.|||||.:|:|::|:||:||||....|:|.|..:||
Zfish   284 VNATDKDQRGGDNWRIKYTIV--NPSGHFAIRTDPVSNQGIISVVKSLDYEYQAEYKLIVKAENE 346

Human   346 APLQAAALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAEGAPPGTLVATFSARDPDTEQLQRL 410
            ..|::...:..  .|.|.|.|.:.||.|:|.:||::.::.|...|||::.:..|.|||..:|:
Zfish   347 VKLKSPYEQIH--SATVTVRVMNENEAPIFYKNPIKVTVPESVVPGTILVSDIAHDPDHAKLR-- 407

Human   411 SYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGWYRAIVLAQDDASQPRTATGTLSIEILE 475
             :....||::||.:|.:||:|..:......|||::...|.|:|...|..:...:||.||.:.:.|
Zfish   408 -FEIIQDPDEWLAIDHSTGQIMAKKNFKIRSPFVRNNIYSAVVKVTDQDADGISATATLEVNLWE 471

Human   476 VNDHAPVLAPPPPGSLCSEPHQGP---GLLLGATDEDLPPHGAPFHFQLSPRLPELGRNWSLSQV 537
            .||:.|:|. |..|::||:  :.|   ||||.|.|||:.|...||.|.::.:  .:..||::..:
Zfish   472 TNDYPPLLI-PQSGTVCSD--RDPDKLGLLLSALDEDMSPQADPFTFNIADQ--NMAANWTIITL 531

Human   538 NVSHARLRPRHQVPEGLHRLSLLLRDSGQPPQQREQPLNVTVCRCGKDGVCLPGAAALLAGGTGL 602
            |.:||.|:|...:..|...:.:::.|||.|.......:|||||.|...|.|....||:.....|:
Zfish   532 NETHAVLQPLVDIERGEFSIPVVVSDSGSPSLYSSALVNVTVCPCDSFGDCKSITAAIFGSKIGI 596

Human   603 SLGALVIVLASALLLLVLVLL-VALRARFWKQSR-GKGLL-HGPQDDLRDNVLNYDEQGGGEEDQ 664
            |..||:|::....|||||:|| ||:|:...:..| |.||| .|..||:||||.:||||||||||:
Zfish   597 SFIALMIIIGCIALLLVLLLLTVAVRSCTSQNIRKGGGLLVGGSDDDIRDNVFHYDEQGGGEEDE 661

Human   665 DAYDISQLRHPTAL------------SLPLGPPPLRRDAPQGRLHPQPPRVLPTSPLDIADFIND 717
            :|::|..||.|:.:            .||.|..|||:|||.....|..||..|..|.||.||||.
Zfish   662 EAFNIDFLRSPSDMLPAPASFFPQDCGLPRGKQPLRKDAPHYLPSPTYPRKPPGDPTDIEDFINV 726

Human   718 GLEAADSDPSVPPYDTALIYDYEGDGSVAGTLSSILSSQGDEDQDYDYLRDWGPRFARLADMY 780
            ||:|||:||:||||||||||||||||||||:||||.|:..|.|||||||.||||||.:||:||
Zfish   727 GLDAADNDPNVPPYDTALIYDYEGDGSVAGSLSSIASTGSDGDQDYDYLNDWGPRFKKLANMY 789

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDH15	NP_004924.1	Cadherin_repeat	52..148	CDD:206637	53/95 (56%)
		Cadherin_repeat	157..256	CDD:206637	54/105 (51%)
		Cadherin_repeat	271..371	CDD:206637	38/99 (38%)
		Cadherin_repeat	379..479	CDD:206637	31/99 (31%)
		E_set	487..580	CDD:298831	31/95 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	636..663		19/27 (70%)
		Cadherin_C	640..781	CDD:279398	93/154 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	676..703		11/38 (29%)
cdh15	NP_997771.2	E_set	45..144	CDD:298831	56/98 (57%)
		Cadherin_repeat	152..259	CDD:206637	54/106 (51%)
		Cadherin_repeat	267..370	CDD:206637	40/106 (38%)
		Cadherin_repeat	378..474	CDD:206637	30/98 (31%)
		E_set	482..574	CDD:298831	31/95 (33%)
		Cadherin_C	639..790	CDD:279398	92/151 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194337593
Domainoid	1	1.000	185	1.000	Domainoid score	I14055
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3622
Inparanoid	1	1.050	634	1.000	Inparanoid score	I4914
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG40397
OrthoDB	1	1.010	-	-		D150696at7742
OrthoFinder	1	1.000	-	-		FOG0011795
OrthoInspector	1	1.000	-	-		oto42166
orthoMCL	1	0.900	-	-		OOG6_101517
Panther	1	1.100	-	-	LDO	PTHR24027
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8142
SonicParanoid	1	1.000	-	-		X9588
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	16	16.440