DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRPPRC and AEP3

DIOPT Version :10

Sequence 1:NP_573566.2 Gene:LRPPRC / 10128 HGNCID:15714 Length:1394 Species:Homo sapiens
Sequence 2:NP_015320.1 Gene:AEP3 / 856102 SGDID:S000005926 Length:606 Species:Saccharomyces cerevisiae


Alignment Length:521 Identity:107/521 - (20%)
Similarity:183/521 - (35%) Gaps:158/521 - (30%)


- Green bases have known domain annotations that are detailed below.


Human   919 RSARLQWFCDRCVANNQVETLEKLVELTQKLFECDRDQMYYNLLKLYKINGDWQRADAVWNKIQE 983
            |:.|:..|..:..::|:.:.|     ||.|..|..|:     ||.|.        .|...|   |
Yeast   100 RAKRMYMFSKQTNSSNKFQKL-----LTAKSQEFTRE-----LLTLL--------IDCTSN---E 143

Human   984 ENVIPREKTLRLLAEILREGNQEVPFDVPELWYEDEKHSLNSSSASTTEPDFQKD---------I 1039
            :|..|.    |...:.|:..|.|:|                      ..|||.|:         |
Yeast   144 KNSGPE----RFTRKFLKFSNDEIP----------------------PLPDFSKNPQLFENYIGI 182

Human  1040 LIACRLNQKKGAYDIFLNAKEQNIV------------------FNAETYSNLIKLLMSEDYFTQA 1086
            |...:.|.:.       ::|...||                  .:|:.|::.|       ||   
Yeast   183 LSHTKFNFRS-------SSKLNGIVRKMLRHLLHPTNKTTLPLRSAQVYNDSI-------YF--- 230

Human  1087 MEVKAFAETHIKGFTLNDAANSRLIITQVRRDYLKEAVTTLKTVLDQQQTPSRLAVTR------- 1144
                 |:| |.      |.|:.|.|..|::.:..|....|...:|......|.:..|:       
Yeast   231 -----FSE-HF------DFASCREIFAQMKAEGTKPNTITFNLLLRNVVKNSHIRKTKHPDDEVL 283

Human  1145 -VIQALAMKGDVENIEVVQKMLNGLEDSIGLSKMVFI---------NNIALAQIKNNNIDAAIEN 1199
             .::::...|...::.......|.|.|.:  |:.::|         .|:........|.|...|:
Yeast   284 FYLRSMRNHGVFADVITWTTCYNFLRDEV--SRQLYIVQMGEHLGNFNVNFVYTVLRNGDYRAED 346

Human  1200 IENMLTSENKVIEPQYFGLAYLFRKVIEEQLEPAVEKISIMAERLANQFAIYKPVTDFFLQL-VD 1263
            ...:|.:.:..|..:.|.|. :.|.:.|||||.|.:.:....:.|.:.|.:.....:.|::: .:
Yeast   347 CLKVLAANSLPISRKTFYLC-IERLLNEEQLETASKLLDYGFQHLKSNFKLDSEAMNHFMRVFAN 410

Human  1264 AGKVDDARALLQRCGAIAEQTP------ILLLFLLRNSRKQGKASTVKSVLELIPELNEKE---- 1318
            .|:.|.|......|..|.:..|      :|...|:||    |......:||:.|.:|...|    
Yeast   411 KGRSDLAFLCYNTCRKIYKIKPDSQTFEMLFKALVRN----GNTKNFGAVLQYIKDLKVSEGFGL 471

Human  1319 -EAY-----NSLMK----SYVSEKDVTSAKALYEHLTA-------KNTKLDDLFLKRYASLLKYA 1366
             .:|     :|:.|    :.:|||.:..|:.|..:|.|       |..|..|...|:   :|::.
Yeast   472 RTSYWRTKADSIFKFGSPNTLSEKSIEKARKLLGNLIASEGEFSWKIWKESDSSQKK---ILRFL 533

Human  1367 G 1367
            |
Yeast   534 G 534

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRPPRCNP_573566.2 PPR 1 126..160
PPR repeat 126..156 CDD:276811
PLN03218 <144..>284 CDD:215636
PPR 2 161..195
PPR repeat 164..191 CDD:276811
PPR 3 196..230
PPR repeat 199..226 CDD:276811
PPR 4 231..265
PPR repeat 232..261 CDD:276811
PPR 5 266..300
PPR repeat 267..296 CDD:276811
PPR 6 301..335
PPR repeat 303..327 CDD:276811
PPR 7 403..437
PPR 8 438..472
PPR 9 678..709
PPR 10 710..746
Interaction with BECN1 and Aedes aegypti venom allergen-1. /evidence=ECO:0000269|PubMed:31937766 712..1067 33/174 (19%)
PPR repeat 714..740 CDD:276811
PPR repeat 746..777 CDD:276811
PPR repeat 786..810 CDD:276811
PPR repeat 1039..1061 CDD:276811 4/21 (19%)
LapB 1046..1311 CDD:442196 59/306 (19%)
PPR 16 1066..1102 8/35 (23%)
PPR repeat 1067..1098 CDD:276811 8/30 (27%)
PPR 17 1103..1137 8/33 (24%)
PPR repeat 1104..1128 CDD:276811 7/23 (30%)
RNA-binding 1121..1394 61/292 (21%)
AEP3NP_015320.1 PPR repeat 223..250 CDD:276811 12/48 (25%)
PPR repeat 256..292 CDD:276811 4/35 (11%)
PPR repeat 367..392 CDD:276811 8/24 (33%)
PPR_2 397..446 CDD:463778 9/48 (19%)
PPR repeat 398..428 CDD:276811 5/29 (17%)
Blue background indicates that the domain is not in the aligned region.

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