Protein Alignment LRPPRC and lrpprc

DIOPT Version :10

• Sequence 1: NP_573566.2
• Gene: LRPPRC / 10128
• HGNCID: 15714
• Length: 1394
• Species: Homo sapiens
• Sequence 2: NP_001039203.1
• Gene: lrpprc / 734062
• XenbaseID: XB-GENE-1014657
• Length: 1391
• Species: Xenopus tropicalis
• Alignment Length: 1410
• Identity: 844/1410 - (59%)
• Similarity: 1069/1410 - (75%)
• Gaps: 41/1410 - (2%)

Human     1 MAALLRSARWLLRAGAAPRLPLSLRLLPGGPGRLHAASYLPAARAGPVAGGLL--SPARLYAIAA 63
            |:|||..||:|||.|        ||.||.           |..|..|..|..|  :|.. :||||
 Frog     1 MSALLAGARFLLRPG--------LRALPA-----------PCVRLSPGQGRYLNNTPGH-FAIAA 45

Human    64 KEK-DIQEESTFSSR-KISNQFDWALMRLDLSVRRTGRIPKKLLQKVFNDTCRSGGLGGSHALLL 126
            ::| .|.||...:.| |.:.||||||.:||.||||||||.|.||||:|:|.||:|....:.||||
 Frog    46 QQKGHIHEEPVSAVRAKQAQQFDWALNKLDSSVRRTGRITKTLLQKIFHDVCRTGYPSSNQALLL 110

Human   127 LRSCGSLLPELKLEERTEFAHRIWDTLQKLGAVYDVSHYNALLKVYLQNEYKFSPTDFLAKMEEA 191
            |||||||||||::.||||.|||||:.||:||||:||||||||||||||||:|||||::|||||.|
 Frog   111 LRSCGSLLPELQMSERTEMAHRIWEKLQELGAVFDVSHYNALLKVYLQNEHKFSPTEYLAKMEAA 175

Human   192 NIQPNRVTYQRLIASYCNVGDIEGASKILGFMKTKDLPVTEAVFSALVTGHARAGDMENAENILT 256
            |:||||||||||||:|||.||||||||||||||.||||:|||||:.||||||||||||||:|||:
 Frog   176 NVQPNRVTYQRLIAAYCNEGDIEGASKILGFMKNKDLPITEAVFNTLVTGHARAGDMENAKNILS 240

Human   257 VMRDAGIEPGPDTYLALLNAYAEKGDIDHVKQTLEKVEKSELHLMDRDLLQIIFSFSKAGYPQYV 321
            |||.|||||||:||:|||.||||||||:::|||||.|||:|..|.||||:|:|:|.:||||||||
 Frog   241 VMRSAGIEPGPETYVALLTAYAEKGDINNIKQTLENVEKNEGSLTDRDLMQVIWSLAKAGYPQYV 305

Human   322 SEILEKVTCERRYIPDAMNLILLLVTEKLEDVALQILLACPVSKEDGPS----VFGSFFLQHCVT 382
            .:|:|::..:|.||||||||.|.|:|:..||||..:|.:...:..|.|:    ..|:|||:|||.
 Frog   306 QDIVERMRYDRGYIPDAMNLCLSLMTQGFEDVAFLVLKSFSAASHDSPNGDSLHHGNFFLRHCVN 370

Human   383 MNTPVEKLTDYCKKLKEVQMHSFPLQFTLHCALLANKTDLAKALMKAVKEEGFPIRPHYFWPLLV 447
            ::.|..|:..:|..|||..:||.||||.|:|:|.|.|.|||..|||.:|:||.|:||||.||||:
 Frog   371 LDKPANKVKQFCDGLKEENLHSAPLQFALYCSLDAKKADLALELMKMMKQEGMPVRPHYCWPLLI 435

Human   448 GRRKEKNVQGIIEILKGMQELGVHPDQETYTDYVIPCFDSVNSARAILQENGCLSDSDMFSQAGL 512
            ..:||||.:|.|:::|.:.|:||..|.|||::||:..|:.|.||||.|||:||..||..|:.|.|
 Frog   436 SFQKEKNAEGTIKVIKALSEIGVELDVETYSNYVLSVFNDVKSARAQLQEHGCTVDSSWFNLAEL 500

Human   513 RSEAANGNLDFVLSFLKSNTLP-ISLQSIRSSLLLGFRRSMNINLWSEITELLYKDGRYCQEPRG 576
            |.:|.:|||:.|.|.|.|.:.| :.|...|.||:..|:||.|::|.::|||||||||||||...|
 Frog   501 RHDAVSGNLEEVYSLLSSPSFPSVDLGHFRGSLITAFKRSNNVDLKAKITELLYKDGRYCQAASG 565

Human   577 PTEAVGYFLYNLIDSMSDSEVQAKEEHLRQYFHQLEKMNVKIPENIYRGIRNLLESYHVPELIKD 641
            |.||||||||||||||||:||||||||||||||||:..|:.|..||||||||||:|.||||||||
 Frog   566 PNEAVGYFLYNLIDSMSDAEVQAKEEHLRQYFHQLKNANIVISANIYRGIRNLLDSSHVPELIKD 630

Human   642 AHLLVESK----NLDFQKTVQLTSSELESTLETLKAENQPIRDVLKQLILVLCSEENMQKALELK 702
            ..:||:|:    :.|..|:.:|.:|.||..:|||||||:|..||||||:::.|||||||||||:|
 Frog   631 VIVLVDSQETLTSSDIAKSAELKASTLEEEIETLKAENKPFGDVLKQLVMIHCSEENMQKALEVK 695

Human   703 AKYESD-MVTGGYAALINLCCRHDKVEDALNLKEEFDRLDSSAVLDTGKYVGLVRVLAKHGKLQD 766
            ||||.: :..|.|||||.||||||..::|||||:|.:|.||||||||.||:.||:|..|:|::.|
 Frog   696 AKYEQENLAIGTYAALIQLCCRHDNPDEALNLKQELNRKDSSAVLDTSKYLALVKVFGKNGRIAD 760

Human   767 AINILKEMKEKDVLIKDTTALSFFHMLNGAALRGEIETVKQLHEAIVTLGLAEPSTNISFPLVTV 831
            |||:|||||||||.:|:||..||||:||.|||||:.|||.::||:|||||||:|::|:..|||:|
 Frog   761 AINVLKEMKEKDVPLKETTTTSFFHILNAAALRGDAETVDKIHESIVTLGLAKPTSNLCSPLVSV 825

Human   832 HLEKGDLSTALEVAIDCYEKYKVLPRIHDVLCKLVEKGETDLIQKAMDFVSQEQGEMVMLYDLFF 896
            |||||||..|:|....|.:||..:||:|||||:|||||:|||:|||||.:|||:|||.|||||.|
 Frog   826 HLEKGDLPAAMETLFTCSKKYNCMPRLHDVLCRLVEKGDTDLLQKAMDHISQERGEMAMLYDLLF 890

Human   897 AFLQTGNYKEAKKIIETPGIRARSARLQWFCDRCVANNQVETLEKLVELTQKLFECDRDQMYYNL 961
            |||.||.||||:|||||||:|||..|||||.::|:|.||:|.||.||::||||||||||.|||.|
 Frog   891 AFLHTGKYKEARKIIETPGLRARPGRLQWFAEKCIATNQMEALENLVDMTQKLFECDRDDMYYYL 955

Human   962 LKLYKINGDWQRADAVWNKIQEENVIPREKTLRLLAEILREGNQEVPFDVPELWYED--EKHSLN 1024
            |||.|.|.||::||:.|.|||||||||||:||||||:|.|...|||||||||.||:|  |...|.
 Frog   956 LKLCKENDDWKKADSAWTKIQEENVIPRERTLRLLADIFRRNGQEVPFDVPETWYKDAAESKVLA 1020

Human  1025 SSSA-STTEPDFQKDILIACRLNQKKGAYDIFLNAKEQNIVFNAETYSNLIKLLMSEDYFTQAME 1088
            |||| |:.|..|||.:.:..:.|:.|.||:.|:..:......:|..||:||:.::||....:|.:
 Frog  1021 SSSAPSSPESSFQKRVQVLSKKNRAKDAYEAFMEGENNGTAMSASAYSSLIRSMLSEGMLEEAKK 1085

Human  1089 VKAFAETHIKGFTLNDAANSRLIITQVRRDYLKEAVTTLKTVLDQQQTPSRLAVTRVIQALAMKG 1153
            |...||.|||||||||||:|.||||||||||||:|:.:||.:|:..:.|::|||||::||||:||
 Frog  1086 VLNTAENHIKGFTLNDAASSLLIITQVRRDYLKDALASLKAMLEGDKVPTQLAVTRLVQALALKG 1150

Human  1154 DVENIEVVQKMLNGLEDSIGLSKMVFINNIALAQIKNNNIDAAIENIENMLTSENKVIEPQYFGL 1218
            |:|.||||:.|:..:..||.||:|:||||..||.:|....:.|||.||.:.|.    .:.|...:
 Frog  1151 DLEGIEVVENMMRNIGSSIRLSQMLFINNKMLAHLKRGKTEEAIELIEPLYTG----TDSQVTSI 1211

Human  1219 AYLFRKVIEEQLEPAVEKISIMAERLANQFAIYKPVTDFFLQLVDAGKVDDARALLQRCGAIAEQ 1283
            :|:|||.:||::|.|:||:|.||||||||||:|:||||.|||.:..|:.||||.||||||:||||
 Frog  1212 SYVFRKAMEEKMESALEKLSGMAERLANQFAVYRPVTDLFLQYIQVGRKDDARFLLQRCGSIAEQ 1276

Human  1284 TPILLLFLLRNSRKQGKASTVKSVLELIPELNEKEEAYNSLMKSYVSEKDVTSAKALYEHLTAKN 1348
            ||:|:.|:.|:::..|:|..:|.:||||||.:|:|.||:.|||.|.::||.|:|.||||.:.:::
 Frog  1277 TPVLVSFISRSAQIPGQAQLIKDLLELIPEFSERETAYSYLMKCYATDKDATAATALYEKMKSES 1341

Human  1349 TKLDDLFLKRYASLLKYAGEPVPFIEPPESFEFYAQQLRKLRENS 1393
            ...|:|||||.|.||:.|||||||.||||||:|||.:|:|.:.:|
 Frog  1342 VSPDELFLKRLAVLLREAGEPVPFSEPPESFKFYADKLKKDKADS 1386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LRPPRC	NP_573566.2	PPR 1	126..160		26/33 (79%)
		PPR repeat	126..156	CDD:276811	23/29 (79%)
		PLN03218	<144..>284	CDD:215636	117/139 (84%)
		PPR 2	161..195		28/33 (85%)
		PPR repeat	164..191	CDD:276811	23/26 (88%)
		PPR 3	196..230		30/33 (91%)
		PPR repeat	199..226	CDD:276811	24/26 (92%)
		PPR 4	231..265		28/33 (85%)
		PPR repeat	232..261	CDD:276811	24/28 (86%)
		PPR 5	266..300		24/33 (73%)
		PPR repeat	267..296	CDD:276811	21/28 (75%)
		PPR 6	301..335		18/33 (55%)
		PPR repeat	303..327	CDD:276811	15/23 (65%)
		PPR 7	403..437		20/33 (61%)
		PPR 8	438..472		18/33 (55%)
		PPR 9	678..709		22/31 (71%)
		PPR 10	710..746		23/35 (66%)
		Interaction with BECN1 and Aedes aegypti venom allergen-1. /evidence=ECO:0000269|PubMed:31937766	712..1067		227/357 (64%)
		PPR repeat	714..740	CDD:276811	17/25 (68%)
		PPR repeat	746..777	CDD:276811	19/30 (63%)
		PPR repeat	786..810	CDD:276811	14/23 (61%)
		PPR repeat	1039..1061	CDD:276811	5/21 (24%)
		LapB	1046..1311	CDD:442196	136/264 (52%)
		PPR 16	1066..1102		16/35 (46%)
		PPR repeat	1067..1098	CDD:276811	12/30 (40%)
		PPR 17	1103..1137		21/33 (64%)
		PPR repeat	1104..1128	CDD:276811	17/23 (74%)
		RNA-binding	1121..1394		145/273 (53%)
lrpprc	NP_001039203.1	PPR 1	110..144		26/33 (79%)
		PPR repeat	113..140	CDD:276811	20/26 (77%)
		PPR_3	132..194	CDD:316342	51/61 (84%)
		PPR 2	145..179		28/33 (85%)
		PPR repeat	148..175	CDD:276811	23/26 (88%)
		PLN03218	<167..>323	CDD:215636	117/155 (75%)
		PPR 3	180..214		30/33 (91%)
		PPR repeat	183..210	CDD:276811	24/26 (92%)
		PPR 4	215..249		28/33 (85%)
		PPR repeat	216..245	CDD:276811	24/28 (86%)
		PPR 5	250..284		24/33 (73%)
		PPR repeat	251..280	CDD:276811	21/28 (75%)
		PPR 6	389..425		20/35 (57%)
		PPR repeat	678..701	CDD:276811	17/22 (77%)
		PLN03218	<690..>881	CDD:215636	123/190 (65%)
		PPR 7	704..738		21/33 (64%)
		PPR repeat	707..734	CDD:276811	17/26 (65%)
		PPR 8	741..775		22/33 (67%)
		PPR repeat	742..771	CDD:276811	17/28 (61%)
		PPR 9	779..813		23/33 (70%)
		PPR repeat	780..807	CDD:276811	16/26 (62%)
		PPR 10	815..850		17/34 (50%)
		PPR 11	948..982		23/33 (70%)
		PPR 12	1028..1062		9/33 (27%)
		PPR repeat	1036..1058	CDD:276811	5/21 (24%)
		PPR 13	1063..1093		11/29 (38%)
		PPR repeat	1064..1095	CDD:276811	12/30 (40%)
		PPR 14	1100..1134		21/33 (64%)
		PPR repeat	1101..1129	CDD:276811	19/27 (70%)
		RNA-binding. /evidence=ECO:0000250	1118..1387		145/273 (53%)
		PPR repeat	1136..1164	CDD:276811	18/27 (67%)
		PPR repeat	1173..1198	CDD:276811	11/24 (46%)