DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LRPPRC and Lrpprc

DIOPT Version :10

Sequence 1:NP_573566.2 Gene:LRPPRC / 10128 HGNCID:15714 Length:1394 Species:Homo sapiens
Sequence 2:NP_082509.2 Gene:Lrpprc / 72416 MGIID:1919666 Length:1392 Species:Mus musculus


Alignment Length:1394 Identity:1049/1394 - (75%)
Similarity:1202/1394 - (86%) Gaps:2/1394 - (0%)


- Green bases have known domain annotations that are detailed below.


Human     1 MAALLRSARWLLRAGAAPRLPLSLRLLPGGPGRLHAASYLPAARAGPVAGGLLSPARLYAIAAKE 65
            ||||||.|||||.|.|||||||||||..|.||||.:...:.|..:.|.||..||.||||||.|::
Mouse     1 MAALLRPARWLLGAAAAPRLPLSLRLPAGVPGRLSSVVRVAAVGSRPAAGERLSQARLYAIVAEK 65

Human    66 KDIQEESTFSSRKISNQFDWALMRLDLSVRRTGRIPKKLLQKVFNDTCRSGGLGGSHALLLLRSC 130
            :|:|||.. ..||.|:||||||||||.||||||||.|.|||:||..||.||..|.:.||||||||
Mouse    66 RDLQEEPA-PVRKNSSQFDWALMRLDNSVRRTGRITKGLLQRVFESTCSSGSPGSNQALLLLRSC 129

Human   131 GSLLPELKLEERTEFAHRIWDTLQKLGAVYDVSHYNALLKVYLQNEYKFSPTDFLAKMEEANIQP 195
            |||||||.|.|||||||:|||.||:||.|||||||||||||||||||||||||||||||.|||||
Mouse   130 GSLLPELSLAERTEFAHKIWDKLQQLGVVYDVSHYNALLKVYLQNEYKFSPTDFLAKMEGANIQP 194

Human   196 NRVTYQRLIASYCNVGDIEGASKILGFMKTKDLPVTEAVFSALVTGHARAGDMENAENILTVMRD 260
            ||||||||||:|||||||||||||||||||||||:||||||||||||||||||||||||||||:.
Mouse   195 NRVTYQRLIAAYCNVGDIEGASKILGFMKTKDLPITEAVFSALVTGHARAGDMENAENILTVMKQ 259

Human   261 AGIEPGPDTYLALLNAYAEKGDIDHVKQTLEKVEKSELHLMDRDLLQIIFSFSKAGYPQYVSEIL 325
            ||||||||||||||||:||:|||..|:|.|||||||:.:.||||.||:|||||||||||||||||
Mouse   260 AGIEPGPDTYLALLNAHAERGDIGQVRQILEKVEKSDHYFMDRDFLQVIFSFSKAGYPQYVSEIL 324

Human   326 EKVTCERRYIPDAMNLILLLVTEKLEDVALQILLACPVSKEDGPSVFGSFFLQHCVTMNTPVEKL 390
            ||:|.|||.|||||||||.|.||||||.|.|:|||.|:||::....||||||:||||::.|.|||
Mouse   325 EKITYERRSIPDAMNLILFLATEKLEDTAFQVLLALPLSKDESSDNFGSFFLRHCVTLDLPPEKL 389

Human   391 TDYCKKLKEVQMHSFPLQFTLHCALLANKTDLAKALMKAVKEEGFPIRPHYFWPLLVGRRKEKNV 455
            .|||::|::.::||..|||||||||.||:|.||||:|:|::|||||||||||||||.|.:|.|||
Mouse   390 IDYCRRLRDAKLHSSSLQFTLHCALQANRTALAKAVMEALREEGFPIRPHYFWPLLAGHQKTKNV 454

Human   456 QGIIEILKGMQELGVHPDQETYTDYVIPCFDSVNSARAILQENGCLSDSDMFSQAGLRSEAANGN 520
            ||||:|||.|.::||.||||||.:||.|||||..|.||.||||.||..|..|:||.:::||.|||
Mouse   455 QGIIDILKIMNKVGVDPDQETYINYVFPCFDSAQSVRAALQENECLLASSTFAQAEVKNEAINGN 519

Human   521 LDFVLSFLKSNTLPISLQSIRSSLLLGFRRSMNINLWSEITELLYKDGRYCQEPRGPTEAVGYFL 585
            |..:||||:|||||.|..|:|:||:|||||||||:|||:||||||||.|||.:|.||.|||||||
Mouse   520 LQNILSFLESNTLPFSFSSLRNSLILGFRRSMNIDLWSKITELLYKDERYCSKPPGPAEAVGYFL 584

Human   586 YNLIDSMSDSEVQAKEEHLRQYFHQLEKMNVKIPENIYRGIRNLLESYHVPELIKDAHLLVESKN 650
            |||||||||||||||||.||||||||::||||:|||||:||.|||.:|||||||||..:||:.:.
Mouse   585 YNLIDSMSDSEVQAKEERLRQYFHQLQEMNVKVPENIYKGICNLLNTYHVPELIKDIKVLVDREK 649

Human   651 LDFQKTVQLTSSELESTLETLKAENQPIRDVLKQLILVLCSEENMQKALELKAKYESDMVTGGYA 715
            :|.|||.|:|||:||||||.||||.||:...||||:|:||||||||||||:|||||||||.||||
Mouse   650 VDSQKTSQVTSSDLESTLEKLKAEGQPVGSALKQLLLLLCSEENMQKALEVKAKYESDMVIGGYA 714

Human   716 ALINLCCRHDKVEDALNLKEEFDRLDSSAVLDTGKYVGLVRVLAKHGKLQDAINILKEMKEKDVL 780
            ||||||||||..|||.|||:|.||||:||:|||.|||.||:||.||.:||||||||||||||||:
Mouse   715 ALINLCCRHDNAEDAWNLKQEVDRLDASAILDTAKYVALVKVLGKHSRLQDAINILKEMKEKDVV 779

Human   781 IKDTTALSFFHMLNGAALRGEIETVKQLHEAIVTLGLAEPSTNISFPLVTVHLEKGDLSTALEVA 845
            |||.|.|||||:||||||||||||||||||||||||||:||:||||||||||||||||..|||.:
Mouse   780 IKDATVLSFFHILNGAALRGEIETVKQLHEAIVTLGLAKPSSNISFPLVTVHLEKGDLPAALEAS 844

Human   846 IDCYEKYKVLPRIHDVLCKLVEKGETDLIQKAMDFVSQEQGEMVMLYDLFFAFLQTGNYKEAKKI 910
            |.|::||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||
Mouse   845 IACHKKYKVLPRIHDVLCKLVEKGETDLIQKAMDFVSQEQGEMTMLYDLFFAFLQTGNYKEAKKI 909

Human   911 IETPGIRARSARLQWFCDRCVANNQVETLEKLVELTQKLFECDRDQMYYNLLKLYKINGDWQRAD 975
            |||||||||..|||||||||:|:||||.||||||||:||||||||||||||||||||:.||||||
Mouse   910 IETPGIRARPTRLQWFCDRCIASNQVEALEKLVELTEKLFECDRDQMYYNLLKLYKISSDWQRAD 974

Human   976 AVWNKIQEENVIPREKTLRLLAEILREGNQEVPFDVPELWYEDEKHSLNSSSASTTEPDFQKDIL 1040
            |.|.|:||||:||||:|||||||||:..||||||||||||:.|::.||:.||.|..|...:|.:|
Mouse   975 AAWTKMQEENIIPRERTLRLLAEILKTSNQEVPFDVPELWFGDDRPSLSPSSRSAGEDVTEKTLL 1039

Human  1041 IACRLNQKKGAYDIFLNAKEQNIVFNAETYSNLIKLLMSEDYFTQAMEVKAFAETHIKGFTLNDA 1105
            ..|:|.:.|.||:|||.|::||:||::||||.||.||:|:|.|||||.||.||||||||||||||
Mouse  1040 SNCKLKKSKDAYNIFLKAEKQNVVFSSETYSTLIGLLLSKDDFTQAMHVKDFAETHIKGFTLNDA 1104

Human  1106 ANSRLIITQVRRDYLKEAVTTLKTVLDQQQTPSRLAVTRVIQALAMKGDVENIEVVQKMLNGLED 1170
            |||.|||.||||||||.|:.||:..||.:|.||::||||:|||||:|||||:||.:|:|:.|| |
Mouse  1105 ANSLLIIRQVRRDYLKGALATLRAALDLKQVPSQIAVTRLIQALALKGDVESIEAIQRMVAGL-D 1168

Human  1171 SIGLSKMVFINNIALAQIKNNNIDAAIENIENMLTSENKVIEPQYFGLAYLFRKVIEEQLEPAVE 1235
            :||||||||||||||||:|||.:||||||||::|.|||:.||||||||:||||||||||:|||:|
Mouse  1169 TIGLSKMVFINNIALAQMKNNKLDAAIENIEHLLASENQAIEPQYFGLSYLFRKVIEEQMEPALE 1233

Human  1236 KISIMAERLANQFAIYKPVTDFFLQLVDAGKVDDARALLQRCGAIAEQTPILLLFLLRNSRKQGK 1300
            |:|||:||:|||||:||||||.||||||:||||:|||||:||||||||:.:|.:|.||.|:|..|
Mouse  1234 KLSIMSERMANQFALYKPVTDLFLQLVDSGKVDEARALLERCGAIAEQSSLLSVFCLRTSQKPKK 1298

Human  1301 ASTVKSVLELIPELNEKEEAYNSLMKSYVSEKDVTSAKALYEHLTAKNTKLDDLFLKRYASLLKY 1365
            |..:|::|||||||.:.::.|:..||||..:|||.|||||||:|||||.|||||||||||:|||.
Mouse  1299 APVLKTLLELIPELRDNDKVYSCSMKSYALDKDVASAKALYEYLTAKNLKLDDLFLKRYAALLKD 1363

Human  1366 AGEPVPFIEPPESFEFYAQQLRKLRENSS 1394
            .||||||.||||||.||.:||::.||:.|
Mouse  1364 VGEPVPFPEPPESFAFYIKQLKEARESPS 1392

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRPPRCNP_573566.2 PPR 1 126..160 27/33 (82%)
PPR repeat 126..156 CDD:276811 25/29 (86%)
PLN03218 <144..>284 CDD:215636 128/139 (92%)
PPR 2 161..195 32/33 (97%)
PPR repeat 164..191 CDD:276811 26/26 (100%)
PPR 3 196..230 32/33 (97%)
PPR repeat 199..226 CDD:276811 25/26 (96%)
PPR 4 231..265 31/33 (94%)
PPR repeat 232..261 CDD:276811 27/28 (96%)
PPR 5 266..300 25/33 (76%)
PPR repeat 267..296 CDD:276811 22/28 (79%)
PPR 6 301..335 29/33 (88%)
PPR repeat 303..327 CDD:276811 21/23 (91%)
PPR 7 403..437 24/33 (73%)
PPR 8 438..472 24/33 (73%)
PPR 9 678..709 23/30 (77%)
PPR 10 710..746 28/35 (80%)
Interaction with BECN1 and Aedes aegypti venom allergen-1. /evidence=ECO:0000269|PubMed:31937766 712..1067 283/354 (80%)
PPR repeat 714..740 CDD:276811 20/25 (80%)
PPR repeat 746..777 CDD:276811 24/30 (80%)
PPR repeat 786..810 CDD:276811 21/23 (91%)
PPR repeat 1039..1061 CDD:276811 10/21 (48%)
LapB 1046..1311 CDD:442196 189/264 (72%)
PPR 16 1066..1102 26/35 (74%)
PPR repeat 1067..1098 CDD:276811 22/30 (73%)
PPR 17 1103..1137 23/33 (70%)
PPR repeat 1104..1128 CDD:276811 18/23 (78%)
RNA-binding 1121..1394 191/272 (70%)
LrpprcNP_082509.2 PPR 1 125..159 27/33 (82%)
PPR repeat 128..155 CDD:276811 22/26 (85%)
PLN03218 <143..>296 CDD:215636 137/152 (90%)
PPR 2 160..194 32/33 (97%)
PPR repeat 163..190 CDD:276811 26/26 (100%)
PPR 3 195..229 32/33 (97%)
PPR repeat 198..225 CDD:276811 25/26 (96%)
PPR 4 230..264 31/33 (94%)
PPR repeat 231..260 CDD:276811 27/28 (96%)
PPR 5 265..299 25/33 (76%)
PPR repeat 266..295 CDD:276811 22/28 (79%)
PPR 6 300..334 29/33 (88%)
PPR 7 402..436 24/33 (73%)
PPR 8 437..471 24/33 (73%)
PPR 9 677..708 23/30 (77%)
PPR 10 709..745 28/35 (80%)
PPR repeat 713..739 CDD:276811 20/25 (80%)
PPR 11 746..783 29/36 (81%)
PPR repeat 747..776 CDD:276811 22/28 (79%)
PPR 12 784..820 32/35 (91%)
PPR repeat 785..809 CDD:276811 21/23 (91%)
PPR 13 821..856 26/34 (76%)
RNA-binding 931..1050 83/118 (70%)
PPR 15 1030..1064 14/33 (42%)
PPR 16 1065..1101 26/35 (74%)
PPR repeat 1066..1097 CDD:276811 22/30 (73%)
PPR 17 1102..1136 23/33 (70%)
PPR repeat 1103..1127 CDD:276811 18/23 (78%)
PPR 18 1137..1175 26/38 (68%)
PPR 19 1176..1210 25/33 (76%)
PPR 20 1315..1349 20/33 (61%)

Return to query results.
Submit another query.