Protein Alignment LRPPRC and lrpprc

DIOPT Version :10

• Sequence 1: NP_573566.2
• Gene: LRPPRC / 10128
• HGNCID: 15714
• Length: 1394
• Species: Homo sapiens
• Sequence 2: NP_001136064.1
• Gene: lrpprc / 557195
• ZFINID: ZDB-GENE-030131-7887
• Length: 1436
• Species: Danio rerio
• Alignment Length: 1443
• Identity: 711/1443 - (49%)
• Similarity: 980/1443 - (67%)
• Gaps: 61/1443 - (4%)

Human     1 MAALLRSARWLLRAGAAPRL---------PLSLRLLPGG--------------PGRLHAASYLPA 42
            ||||||||| ||:..:|..:         |.:.||..|.              ||||:|.|....
Zfish     1 MAALLRSAR-LLKTSSASLIQVIGNSKHAPAAGRLYSGAIGTLRVGVCGRQTVPGRLNANSLFSY 64

Human    43 ARAGPVAGGLLSPARLYAIAAKEK-DIQEESTFSSR-KISNQFDWALMRLDLSVRRTGRIPKKLL 105
            ..|.|...     .|.||:..::. .:::|::.:.| |.:.||||||.:||.|||||||:.|.||
Zfish    65 RPALPCVS-----CRQYAVVPEQSGQVKDEASLAVRSKQAQQFDWALSKLDSSVRRTGRVTKTLL 124

Human   106 QKVFNDTCRSGGLGGSHALLLLRSCGSLLPELKLEERTEFAHRIWDTLQKLGAVYDVSHYNALLK 170
            ..:|:|.||:|...|:.||||||||||||||:.|.||||...||||.|.:||..|||||||||||
Zfish   125 LHIFHDICRTGYPSGNQALLLLRSCGSLLPEVPLAERTELVKRIWDKLLELGVSYDVSHYNALLK 189

Human   171 VYLQNEYKFSPTDFLAKMEEANIQPNRVTYQRLIASYCNVGDIEGASKILGFMKTKDLPVTEAVF 235
            .|||||::|||||||||||.||:||||||||||||:||..|:|||||.||||||.||||:|||||
Zfish   190 TYLQNEFRFSPTDFLAKMEAANVQPNRVTYQRLIAAYCEEGNIEGASAILGFMKNKDLPITEAVF 254

Human   236 SALVTGHARAGDMENAENILTVMRDAGIEPGPDTYLALLNAYAEKGDIDHVKQTLEKVEKSELHL 300
            ::||.|||||||:.::|.||:||:.|||||||||||:|||.||||||||.:||||:.||.::..|
Zfish   255 NSLVVGHARAGDITSSEGILSVMKSAGIEPGPDTYLSLLNMYAEKGDIDKIKQTLDVVENADFFL 319

Human   301 MDRDLLQIIFSFSKAGYPQYVSEILEKVTCERRYIPDAMNLILLLVTEKLEDVALQILLA----C 361
            |||||:|::.|.::.|:.|:|.||:.::..||.|:|||:||.|.|:|...|..|..:|.:    .
Zfish   320 MDRDLMQLVSSLARTGHEQHVPEIVSRMRHERGYVPDAINLCLNLITHGHEKTAFSVLKSLTGML 384

Human   362 PVSKEDGPSVFGSFFLQHCVTMNTPVEKLTDYCKKLKEVQMHSFPLQFTLHCALLANKTDLAKAL 426
            .....|.|. ||:|||:|||.|:...|.:..:||.||::.:||.||||||.|||...||.|:..|
Zfish   385 DTHTGDTPD-FGNFFLRHCVNMDKSAEDIVGFCKDLKDLGLHSTPLQFTLQCALEGKKTSLSIGL 448

Human   427 MKAVKEEGFPIRPHYFWPLLVGRRKEKNVQGIIEILKGMQELGVHPDQETYTDYVIPCFDSVNSA 491
            ||.:|.|..||:||||.||.....|:||:..|||:|:||||:.|.||.:.::.|::|.|.|:::|
Zfish   449 MKRMKAESLPIKPHYFLPLFAHHHKDKNIPAIIEVLRGMQEMSVSPDVDAFSFYILPSFPSLDNA 513

Human   492 RAILQENGCLSDSDMFSQAGLRSEAANGNLDFVLSFLKSNTLP-ISLQSIRSSLLLGFRRSMNIN 555
            :|.|:|.|...::|....|.||.:|.:|||..:||.:.|..|| |.|...|:.|:.||:|..|:.
Zfish   514 KASLKEAGVDVNTDGLIVAELRVQAYSGNLAKLLSLMSSPALPTIDLSVFRAGLIAGFKRFQNVE 578

Human   556 LWSEITELLYKDGRYCQEPRGPTEAVGYFLYNLIDSMSDSEVQAKEEHLRQYFHQLEKMNVKIPE 620
            ..::||||||||.|:..:....:|.|||||||||||||::|:|:.||.:|:||..|:.||:.|..
Zfish   579 NMAKITELLYKDARFAADGHDASENVGYFLYNLIDSMSETELQSNEEKIREYFGLLKSMNINISV 643

Human   621 NIYRGIRNLLESYHVPELIKDAHLLVESKNLDFQKTVQLTSSE-----LESTLETLKAENQPIRD 680
            ||:|||||:|||:|||||:|:|..||: |..|..:.:...|||     |..||...|||.:|...
Zfish   644 NIFRGIRNILESHHVPELVKEALTLVD-KTDDMTEVMMFRSSEGRISALVKTLAEQKAEGKPAHL 707

Human   681 VLKQLILVLCSEENMQKALELKAKYESDMVTGGYAALINLCCRHDKVEDALNLKEEFDRLDSSAV 745
            .||:||.||..||.:::||:||:|||.||....||.|||||||||..|:||.||.|..|.||...
Zfish   708 TLKKLINVLSIEEKLEQALDLKSKYEDDMTPAAYATLINLCCRHDNAEEALKLKIEMARKDSEVA 772

Human   746 LDTGKYVGLVRVLAKHGKLQDAINILKEMKEKDVLIKDTTALSFFHMLNGAALRGEIETVKQLHE 810
            ||..||:.|||||:|||||::|::||||||||:::|:|.........:|..|::|:.:.:::|.|
Zfish   773 LDAQKYIALVRVLSKHGKLEEALDILKEMKEKNIMIRDNLIGFLTFTMNSIAMKGDADAIRRLQE 837

Human   811 AIVTLGLAEPSTNISFPLVTVHLEKGDLSTALEVAIDCYEKYKVLPRIHDVLCKLVEKGETDLIQ 875
            .|.|||||:||..:..||||.:||.||.:.|.:..::|:::|..||:|||::|.|||||:..|:|
Zfish   838 TIFTLGLAKPSNGLCSPLVTCYLESGDHAGAFDAVMECHKQYNQLPKIHDLMCSLVEKGDALLLQ 902

Human   876 KAMDFVSQEQGEMVMLYDLFFAFLQTGNYKEAKKIIETPGIRARSARLQWFCDRCVANNQVETLE 940
            |.|:|::.|:|||:|||||||||||||..:||:|||||||:||||.|||||.::|:|..|:|.||
Zfish   903 KVMEFLTLERGEMMMLYDLFFAFLQTGRNREARKIIETPGLRARSNRLQWFAEKCIAAQQMEPLE 967

Human   941 KLVELTQKLFECDRDQMYYNLLKLYKINGDWQRADAVWNKIQEENVIPREKTLRLLAEILREGNQ 1005
            .||::|.||||||||:||:.|.:|.|...||::|:|:|.|:||||:.|||:|||||||||:..||
Zfish   968 NLVDMTVKLFECDRDEMYHYLFRLCKETNDWRKAEAIWMKMQEENLAPRERTLRLLAEILKSNNQ 1032

Human  1006 EVPFDVPELWYEDEK--------HSLNSSSASTTEPDFQKDILIACRLNQ--KKG----AYDIFL 1056
            ||||:||::|:||:|        ...:|:.|..|:...:.:..|..:|..  |||    |:||..
Zfish  1033 EVPFEVPKVWFEDDKGQSEVVPEKEESSAVAKKTDDRSRLNATIRLKLQSLCKKGEAQEAFDILK 1097

Human  1057 NAKEQNIVFNAETYSNLIKLLMSEDYFTQAMEVKAFAETHIKGFTLNDAANSRLIITQVRRDYLK 1121
            ....:.||.....|..:||.|:::.....|:.||..|..||..|.|:|.||:.|||:.|::..:|
Zfish  1098 EVDSKGIVPGPAIYDAIIKALLAKGNIEDAISVKDIAVGHIPSFILSDVANNLLIISHVKKCQMK 1162

Human  1122 EAVTTLKTVLDQQQTPSRLAVTRVIQALAMKGDVENIEVVQKMLNGLEDSIGLSKMVFINNIALA 1186
            ::|..|:.:|...|.||:||:||::|.||.:|::::|:.|:.|.... .|..||.|:|:||.|||
Zfish  1163 DSVQVLRDMLKADQMPSQLAITRLVQGLADEGNLKDIQEVEAMTKAF-GSFNLSNMLFVNNTALA 1226

Human  1187 QIKNNNIDAAIENIENMLTSENKVIEPQYFGLAYLFRKVIEEQLEPAVEKISIMAERLANQFAIY 1251
            .:.|.::|:|::.::...| ||  .|.|...:|::||||:....:.|::|:|.|||||.||||.|
Zfish  1227 LLNNGDVDSAVDMLQTFYT-EN--TERQNNSIAHVFRKVLNANNDAAMDKLSAMAERLCNQFASY 1288

Human  1252 KPVTDFFLQLVDAGKVDDARALLQRCGAIAEQTPILLLFLLRNSRKQGKASTVKSVLELIPELNE 1316
            :..||.||..||.|:.::|:.|||||.|:.||..:|..::||.|::.|:|:.|.|::||||::.|
Zfish  1289 RAATDLFLVYVDTGRTEEAKFLLQRCAAVGEQKDLLFSYVLRASQQPGQAAKVMSLMELIPDIRE 1353

Human  1317 KEEAYNSLMKSYVSEKDVTSAKALYEHLTAKNTKLDDLFLKRYASLLKYAGEPVPFIEPPESFEF 1381
            ||:.|:.|||.:..::|:.|||||||.:..:..::|:|.|||.|.|.:.:||||||.||.|||.|
Zfish  1354 KEDIYSQLMKCHGLDQDLASAKALYERMQVEGVRIDELTLKRLAKLYRDSGEPVPFEEPAESFRF 1418

Human  1382 YAQQLRKLRENSS 1394
            ||.:|:..|..|:
Zfish  1419 YADKLKDQRTQST 1431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LRPPRC	NP_573566.2	PPR 1	126..160		23/33 (70%)
		PPR repeat	126..156	CDD:276811	21/29 (72%)
		PLN03218	<144..>284	CDD:215636	106/139 (76%)
		PPR 2	161..195		28/33 (85%)
		PPR repeat	164..191	CDD:276811	23/26 (88%)
		PPR 3	196..230		27/33 (82%)
		PPR repeat	199..226	CDD:276811	21/26 (81%)
		PPR 4	231..265		22/33 (67%)
		PPR repeat	232..261	CDD:276811	18/28 (64%)
		PPR 5	266..300		23/33 (70%)
		PPR repeat	267..296	CDD:276811	22/28 (79%)
		PPR 6	301..335		14/33 (42%)
		PPR repeat	303..327	CDD:276811	10/23 (43%)
		PPR 7	403..437		19/33 (58%)
		PPR 8	438..472		18/33 (55%)
		PPR 9	678..709		15/30 (50%)
		PPR 10	710..746		20/35 (57%)
		Interaction with BECN1 and Aedes aegypti venom allergen-1. /evidence=ECO:0000269|PubMed:31937766	712..1067		189/368 (51%)
		PPR repeat	714..740	CDD:276811	17/25 (68%)
		PPR repeat	746..777	CDD:276811	21/30 (70%)
		PPR repeat	786..810	CDD:276811	4/23 (17%)
		PPR repeat	1039..1061	CDD:276811	8/27 (30%)
		LapB	1046..1311	CDD:442196	106/270 (39%)
		PPR 16	1066..1102		11/35 (31%)
		PPR repeat	1067..1098	CDD:276811	9/30 (30%)
		PPR 17	1103..1137		12/33 (36%)
		PPR repeat	1104..1128	CDD:276811	9/23 (39%)
		RNA-binding	1121..1394		120/272 (44%)
lrpprc	NP_001136064.1	PPR_3	167..226	CDD:316342	48/58 (83%)
		PPR repeat	183..210	CDD:276811	23/26 (88%)
		PLN03218	<206..>378	CDD:215636	108/171 (63%)
		PPR repeat	218..245	CDD:276811	21/26 (81%)
		PPR repeat	251..280	CDD:276811	18/28 (64%)
		PPR repeat	286..310	CDD:276811	19/23 (83%)
		PLN03218	<695..>806	CDD:215636	65/110 (59%)
		PPR repeat	708..735	CDD:276811	15/26 (58%)
		PPR repeat	738..769	CDD:276811	18/30 (60%)
		PPR repeat	775..804	CDD:276811	19/28 (68%)
		PPR repeat	812..842	CDD:276811	6/29 (21%)
		PPR repeat	1080..1102	CDD:276811	7/21 (33%)
		PPR repeat	1108..1135	CDD:276811	7/26 (27%)
		PPR repeat	1145..1173	CDD:276811	10/27 (37%)
		PPR repeat	1180..1209	CDD:276811	11/28 (39%)