DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRPPRC and bsf

DIOPT Version :10

Sequence 1:NP_573566.2 Gene:LRPPRC / 10128 HGNCID:15714 Length:1394 Species:Homo sapiens
Sequence 2:NP_523596.2 Gene:bsf / 35100 FlyBaseID:FBgn0284256 Length:1412 Species:Drosophila melanogaster


Alignment Length:1406 Identity:425/1406 - (30%)
Similarity:694/1406 - (49%) Gaps:154/1406 - (10%)


- Green bases have known domain annotations that are detailed below.


Human    72 STFSSRKISNQFDWALMRLDLSVRRTGRIPKKLLQKVFNDTCRSGGLGGSHALLLLRSCGSLLPE 136
            :|.::.|.....|..:.|||..|||.|||.::.|::|.::.........|.:||::|.||:|:||
  Fly    50 ATNAAAKAELSLDKQIRRLDQDVRRIGRISRRDLEEVLDEIRSHRTATSSQSLLVIRCCGNLVPE 114

Human   137 LKLEERTEFAHRIWDTLQKLGAVYDVSHYNALLKVYLQNEYKFSPTDFLAKMEEANIQPNRVTYQ 201
            ...|.||.....||.||..|....|:|||||||:|||:||:.|:||||||::|...|:|||||||
  Fly   115 ELPEVRTALVQEIWKTLNALNVPMDISHYNALLRVYLENEHGFAPTDFLAEIEAKGIEPNRVTYQ 179

Human   202 RLIASYCNVGDIEGASKILGFMKTKDLPVTEAVFSALVTGHARAGDMENAENILTVMRDAGIEPG 266
            ||||.||..||||||::||.||:.|.|||.|.||::|:.||::|.|:|:|:.||.||..||:||.
  Fly   180 RLIARYCQQGDIEGATRILEFMRAKSLPVNENVFNSLILGHSQANDLESAKGILGVMMQAGLEPS 244

Human   267 PDTYLALLNAYAEKGDIDHVKQTLEKVEKSELHLMDRDLLQIIFSFSKAGYPQYVSEILEKVTCE 331
            .|||..||.|:|..||:..||:||.:.|:.|:.|:|:|||.|:::.:..|..::|.::|.|:...
  Fly   245 ADTYTTLLCAFARHGDLAAVKETLAECEQKEIILLDKDLLDIVYTLTVNGNGEHVDDVLTKLRLS 309

Human   332 RRYIPDAMNLILLLVTEKLEDVALQILLACP-VSKEDG-PSVFGSFFLQHCVTMNTPVEKLTDYC 394
            ..:..||:|:||.||.:..|||.|::|...| .|:.:| |...|:||::..|..|.||||:...|
  Fly   310 PGFNQDAVNVILRLVNKGHEDVGLKLLRVMPRSSRVNGEPVDVGAFFIRQMVKANRPVEKILSIC 374

Human   395 KKLKEVQMHSFPLQFTLHCALLANKTDLAKALMKAVKEEGFPIRPHYFWPLLVGRRKEKNVQGII 459
            |.|:...::...|.......|.....:.|..|::.:|..|.|||.||||||:......:    ::
  Fly   375 KSLQSEGLNPKALTIATEAGLTNGVINNALPLLQEMKNAGLPIRQHYFWPLICSAESNQ----VL 435

Human   460 EILKGM-QELGVHPDQETYTDYVIPCFDSVNSARAI--LQENGCLSDSDMFS---------QAGL 512
            ||::.| ||..|.|:.||..|||||.....|..|.:  |::.|..:.:.:.|         |...
  Fly   436 EIVRRMQQEFSVFPNSETVRDYVIPNLKEKNWERIVTSLRDAGVPNSTAVTSAVYSALVTHQIAE 500

Human   513 RSEAANGNLDFVLSFLKSNTLPISLQSIR--SSLL---------LGFRRSMNINLWSEI------ 560
            .::....|..:.:.||....|.::|....  :|.:         |.||:..:    .|:      
  Fly   501 AAKIMEKNRAYYVPFLFKQPLILALSHTNDYASFIRCVRQIHEGLQFRQGKD----EEVEQVEGV 561

Human   561 ----TELLYKD--GRYCQEPRGPTEAVGYF-------LYNLIDSMSDSEVQAKEEHLRQYFHQL- 611
                ||.:..|  |...|      ||..||       |..::..:....:....:...|...|| 
  Fly   562 AAVPTERITPDVVGAIVQ------EATTYFRRDRGATLEKILKGLVKQGLSISSDKATQLSEQLG 620

Human   612 EKMNVKIPENIYRGIRNLLESYHVPELIKDAHLLVESKNLDFQKTVQLTSSELESTLETLKAENQ 676
            .::..||.|.:.:.....||...:|...|        ::||     .|:.:|||..:..::.:.:
  Fly   621 SELTPKISELLGKLSSGELEPVPLPNSGK--------RSLD-----SLSINELERFIVNVEGKGE 672

Human   677 PIRDVLKQLILVLCSEENMQKALELKAKYESD---MVTGGYAALINLCCRHDKVEDALNLKEEFD 738
            ...::.:||:......:|::|.|::..|.|::   :..|.||.||:|...|.|..:||.:..:..
  Fly   673 NANNIKRQLLNACFRSQNLEKTLQVIEKLEAEKFQIPVGIYAQLIDLNTHHKKSSEALEIYGKLK 737

Human   739 RLDSSAVLDTGKYVGLVRVLAKHGKLQDAINILKEMKEKDVLIKDTTALSFFHM------LNGAA 797
            ..|::..||..|.|.|..:|.:..::..|..||:|.| |:|.:.:... |:.:|      ||..|
  Fly   738 AKDATFQLDNLKAVRLADLLLQEERVDAAFKILEENK-KEVPVAEAEG-SYNYMSTVWRILNSLA 800

Human   798 LRGEIETVKQLHEAIVTLGLAEPSTNISFPLVTVHLEKGDLSTALEVAIDCYEKYKVLPRIHDVL 862
            ..|:.|.:::|.:.:|......|:..:..||:.|||.|.|:..|:|...:..:|||..|..:::.
  Fly   801 EAGQPERLRKLFDVLVGANYIVPTNVLLGPLIKVHLVKDDIPKAIEAFEEICQKYKSTPWKNELA 865

Human   863 CKLVEKGETDLIQKAMDFVSQEQGEMVMLYDLFFAFLQTGNYKEAKKIIETPGIRARSARLQWFC 927
            |:|::|.:...:||..|..:...||:..||||.|:|::.|..::|:||:||||:|.|..|:...|
  Fly   866 CRLIQKEDAANLQKLTDLSTGIHGEVNSLYDLVFSFVECGRVRQARKILETPGLRTRPQRINSAC 930

Human   928 DRCVANNQVETLEKLVELTQKLFECDRDQMYYNLLKLYKINGDWQRADAVWNKIQEENVIPREKT 992
            ||......::.||.|:|.|:.|...||:::||.||..|....:.::|..:|.|:|||||.|.:..
  Fly   931 DRYKNEGLLQPLEGLIEATKDLGHIDRNKIYYTLLLSYDKADEAEKALGLWTKMQEENVTPNDAF 995

Human   993 LRLLAEILREGNQEVPFDVPELWYEDEKHSLNSSSASTTEPDFQKDILIACRLNQKKGAYDIFLN 1057
            |..|||||.:.|.:|||.|||...|..|...:.:..:||.....:...:|.:..:|.        
  Fly   996 LLKLAEILSKKNIDVPFVVPETQNEQAKAKKSKAKDATTTEAATETAKVAEQPKEKA-------- 1052

Human  1058 AKEQ----NIVFNAETYSNLIKLLMSEDYFTQAMEVK------AFAETHIKGFTLNDAANSRLII 1112
            ||::    ......:|.|:|       ..|.:|::..      :..::.:.|..:.....||||.
  Fly  1053 AKKEPAKTETAKPPKTASHL-------SGFRKAIQANDPDAAISHKQSVLSGEKIGALDTSRLIE 1110

Human  1113 TQVRRDYLKEAVTTLKTVLDQQQTPSRLAVTRVIQALAMKGDVENIEVVQKMLNGLEDSIGLSKM 1177
            ..||.|.|.||...::.:|..:..|........:..:|..||:|.::.:.:.||..:..:    :
  Fly  1111 LLVRADRLTEATKYVEELLGDKLHPQPKIFKFYLNKIAAAGDLETMQRIGQQLNDEQKRL----I 1171

Human  1178 VFINNIALAQIKNNNIDAAIENIENMLTSENKVIEP-QYFGLAYLFRK-----VIEEQLEPAVEK 1236
            .|.|....|.|....   |.|.::::.|..:....| :...||..|.:     ::|:..| .|.:
  Fly  1172 SFDNRFCHANIVAGK---AEEFLKHLTTEIDAAKTPEESTKLAEKFPRGGAVGILEKHPE-LVPQ 1232

Human  1237 ISIMAERLA--NQFAIYKPVTDFFLQLVDAGKVDDARALLQRCGAIAEQTPILLLFLLRNSRKQG 1299
            ...:||:.|  ||..   |:...::.|:..|:...::.:..:  .::....::...:|:.:|:|.
  Fly  1233 YQSLAEKFAAHNQLG---PMNVLWMHLISTGQEAASKEIWDK--HLSNAPRLMFQRVLQTAREQQ 1292

Human  1300 K---ASTVKSVLELIPELNEK------EEAYNSLMKSYVSEKDVTSAKALYEHLTA-KNTKLDDL 1354
            .   ||||.|.|:     |.|      ..||:.|:....::.:  |.||:.....| |:..|:: 
  Fly  1293 DEKLASTVISQLK-----NSKISEGAIGNAYSCLIDIQTTKGN--SDKAMVVLANAIKDVSLEN- 1349

Human  1355 FLKRYASL-LKYAGEPVPFIEPPESFEFYAQQLRKLRENSS 1394
             :.|.|.| ||.|.|     |..:.|.:...:.|...::||
  Fly  1350 -INRTALLRLKQAVE-----EKSQKFPYTIPEKRTKADDSS 1384

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRPPRCNP_573566.2 PPR 1 126..160 14/33 (42%)
PPR repeat 126..156 CDD:276811 13/29 (45%)
PLN03218 <144..>284 CDD:215636 81/139 (58%)
PPR 2 161..195 22/33 (67%)
PPR repeat 164..191 CDD:276811 19/26 (73%)
PPR 3 196..230 24/33 (73%)
PPR repeat 199..226 CDD:276811 19/26 (73%)
PPR 4 231..265 16/33 (48%)
PPR repeat 232..261 CDD:276811 14/28 (50%)
PPR 5 266..300 15/33 (45%)
PPR repeat 267..296 CDD:276811 14/28 (50%)
PPR 6 301..335 9/33 (27%)
PPR repeat 303..327 CDD:276811 7/23 (30%)
PPR 7 403..437 6/33 (18%)
PPR 8 438..472 13/34 (38%)
PPR 9 678..709 7/33 (21%)
PPR 10 710..746 11/35 (31%)
Interaction with BECN1 and Aedes aegypti venom allergen-1. /evidence=ECO:0000269|PubMed:31937766 712..1067 118/364 (32%)
PPR repeat 714..740 CDD:276811 9/25 (36%)
PPR repeat 746..777 CDD:276811 11/30 (37%)
PPR repeat 786..810 CDD:276811 8/29 (28%)
PPR repeat 1039..1061 CDD:276811 4/21 (19%)
LapB 1046..1311 CDD:442196 58/285 (20%)
PPR 16 1066..1102 6/41 (15%)
PPR repeat 1067..1098 CDD:276811 5/36 (14%)
PPR 17 1103..1137 11/33 (33%)
PPR repeat 1104..1128 CDD:276811 10/23 (43%)
RNA-binding 1121..1394 62/291 (21%)
bsfNP_523596.2 PPR repeat 142..169 CDD:276811 19/26 (73%)
PLN03218 <163..>261 CDD:215636 57/97 (59%)
PPR repeat 177..204 CDD:276811 19/26 (73%)
PPR repeat 210..239 CDD:276811 14/28 (50%)
PPR_2 213..257 CDD:463778 22/43 (51%)
PPR repeat 245..274 CDD:276811 14/28 (50%)
Pterin_binding <456..>543 CDD:444759 17/86 (20%)
LapB <661..855 CDD:442196 51/195 (26%)
PPR repeat 681..704 CDD:276811 6/22 (27%)
PPR repeat 710..739 CDD:276811 10/28 (36%)
PPR repeat 780..818 CDD:276811 9/38 (24%)
PPR repeat 825..854 CDD:276811 9/28 (32%)

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