DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRPPRC and ppr5

DIOPT Version :10

Sequence 1:NP_573566.2 Gene:LRPPRC / 10128 HGNCID:15714 Length:1394 Species:Homo sapiens
Sequence 2:NP_594649.2 Gene:ppr5 / 2542921 PomBaseID:SPAC1093.01 Length:1261 Species:Schizosaccharomyces pombe


Alignment Length:1190 Identity:244/1190 - (20%)
Similarity:425/1190 - (35%) Gaps:316/1190 - (26%)


- Green bases have known domain annotations that are detailed below.


Human   312 FSKAGYPQYVSEILEKVTC-----ERRYIPDAMNLILLLVTEKLEDVALQILLACPVSKEDGPSV 371
            ||.:..|..:|.:.:. ||     |:::...|.:.:......::.|..|..|  .|.|.|   |.
pombe   110 FSASLLPASLSSLCDS-TCGDVDDEQQFNSLATSPLSTETQSEVSDPLLDTL--TPNSLE---SS 168

Human   372 FGSFFLQHCVTMNTPVEKLTDYCKKL--KEVQMHSFPLQFTLHCALLANKTDLAKALMKAVKEEG 434
            |.|..|....:.|    :...:.|:|  .::.:|:|.|.     .|:.|..:|       :..|.
pombe   169 FASISLNSFTSAN----EFIQFLKRLASSKLSIHTFDLY-----KLVRNSPEL-------LTLEA 217

Human   435 FPI------RPHYFWPLLVGRRKEKNVQGIIEILKGMQELGVHPDQETYTDYVIPCFDSVNSARA 493
            :.|      ...||      ....||:|.||::...|....:.|:..|:...:   |.....|:.
pombe   218 YNIVLQCMSTDDYF------LSSSKNIQKIIKVYVDMLNSFISPNVTTFETVI---FALCRRAKF 273

Human   494 ILQENGCLSDSDMFSQAGLRSEAANGNLDF---------VLSFLKS---NTLPISLQ----SIRS 542
            :.|:...||...:::...:..|.....||.         |..|..|   :.|..|.|    .|.|
pombe   274 VHQKIESLSKRTIYAHPSIAKEIQPELLDLQSEMPLQTAVFMFTSSLINHDLIYSPQFYAILIES 338

Human   543 SLLLGFRRSMNINLWSEITELLYKDGRYCQEPRGPTEAVGY--FLYNLIDSMSDSEVQAKEEHLR 605
            ..|.|.:        |::..||     .| .|.|..||.|:  .|..||.::      .:.:.|.
pombe   339 VSLYGTQ--------SQLDSLL-----EC-VPLGTIEANGHPDLLPALIRAL------GRAKRLN 383

Human   606 QYFHQLEKMNVKIP------ENIYRGIRNLLESY-----HV--PELIK------DAHLLVESKNL 651
            ..|..||:.|:..|      .|: |....|:|:|     ||  ..|:|      |::.::.|..|
pombe   384 SCFQLLERYNLSDPTSDTSMTNV-RSWEGLMEAYFDTDHHVEASALMKSFFRKADSNQVIPSSIL 447

Human   652 D-----------FQKTVQLTSSELESTLETLKAENQPIRDVLKQLILVLCSEENMQKALELKAKY 705
            |           ::::.:.....:|. :.|.||....:..:|:    ..|...|.:.|:....||
pombe   448 DCFLRRLAQLGHYKESAEWLGMAIEK-ISTYKASPSTLSSILE----AACLNNNDKFAIAFVRKY 507

Human   706 ESDMVTGGYAAL---INLCCRHDKVEDALNLKEEFDRLDSSAVLDTGKYVGLVRVLAKHGKLQDA 767
            .....:..:|.|   ::|..|...| |.|:| ..:..:.|.:......:..:.:...::||:..|
pombe   508 TLSRFSDCHAVLLRYLDLLARSGNV-DLLHL-HAYPVICSVSSHTNFTFSNVYKAFIENGKIDVA 570

Human   768 INILKEMKEKDVLIKDTTALSF------FHMLNG--AALRGEIETVKQLHEAIVTLGLAEPSTN- 823
            :.:|::..:..|.:.:.||.|.      ..:|||  ..|..|::  |.:|   |.|.|.....| 
pombe   571 LRLLRKHIDPKVSLGNNTAPSSNSVALQLSILNGFWEVLTEELQ--KDVH---VLLSLVSTLENQ 630

Human   824 ISFPLVTVHLEKGDLSTALEVAIDCY------EKYKVLPRIHDVLCKLVEKGETDLIQKAMDFVS 882
            ::||.|       |.:|.|...|..|      |...:.||:...   |:|....:::|....|.|
pombe   631 VNFPQV-------DFTTPLLRHITGYLVSRRLEPELISPRVFGF---LLEYAAFNVVQTEGTFTS 685

Human   883 QEQGEMVMLYDLFFAFLQTGNYKEAKK----------IIETPGIRARSARLQWFCDRCVA----N 933
            :     |:|.||...: ..|.||.:.|          .::...:...|.|.....:..|.    |
pombe   686 K-----VILTDLLKCY-SNGTYKASFKNVHVVLRSFTYLKEDEMLVASVRDDIVSEAVVGFSTDN 744

Human   934 NQVETLEKLVELTQKL--FECDRDQMYYNLLKLYKINGDWQRADA-----VWNKIQEENVIPREK 991
            |..:.|..:.::...|  .|| .||...:|:.....:...::.|.     .:.|:.|.|.....:
pombe   745 NGQKILADISQVCYCLDDLEC-IDQSINSLVSKMLTSASPEQVDVNILFFQFGKLIETNKFLHPE 808

Human   992 TLRLLAEILREGNQEVPFDVPELWYEDEKHSLNSSSASTTEPD--FQKDILIACRLN-----QKK 1049
            ....|..:|.:..:   ||..:..:|..||.....|..:.|..  |...||.|..|:     |.|
pombe   809 VYPTLISVLSKNKR---FDAVQRVFEHSKHLYRKISTKSLEKANWFMALILDAMILSSSFARQFK 870

Human  1050 GAYDIFLNAKEQNIVFNAETYSNLIKLLMSEDYFTQAMEVKAFAETHIKGFTLNDAANSRLIITQ 1114
            .:.....|.|....:..|.|:::||.                  .:..:|.| :||..:..|..:
pombe   871 SSNLFCDNMKMLGYIPRASTFAHLIN------------------NSTRRGDT-DDATTALNIFEE 916

Human  1115 VRRDYLKEAVTTLKTVLDQ----QQT----------------PSRLAVTRVIQALAMKGDVENIE 1159
            .:|..:|.:|.....||.:    ::|                |:.:....||.|....||.    
pombe   917 TKRHNVKPSVFLYNAVLSKLGRARRTTECWKLFQEMKESGLLPTSVTYGTVINAACRIGDE---- 977

Human  1160 VVQKMLNGLEDSIGLSKMVFINNIALAQIKNN-NIDAAIENIENMLTSENKVIEPQYFGLAYLFR 1223
                         .|::.:|      |:::|. |....:.....|:..|.:.:..:...|.| :.
pombe   978 -------------SLAEKLF------AEMENQPNYQPRVAPYNTMIQFEVQTMFNREKALFY-YN 1022

Human  1224 KVIEEQLEPAVEKISIMAERLANQFAIYKPVTDFFLQLVDAGKVDDARALLQRCGAIAEQTPILL 1288
            ::....:||:.....:    |.:.:...|||                                  
pombe  1023 RLCATDIEPSSHTYKL----LMDAYGTLKPV---------------------------------- 1049

Human  1289 LFLLRNSRKQGKASTVKSVLEL-----IPELNEKEEAYNSLMKSYVSEKDVTSAKALYEHLTAKN 1348
                       ...:||:||||     :|.|:....||..::.:.||  ||.:|.:.|.:..||:
pombe  1050 -----------NVGSVKAVLELMERTDVPILSMHYAAYIHILGNVVS--DVQAATSCYMNALAKH 1101

Human  1349 ----TKLD-DLFLKRYASLL 1363
                .:|| :||..:..||:
pombe  1102 DAGEIQLDANLFQSQIESLI 1121

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRPPRCNP_573566.2 PPR 1 126..160
PPR repeat 126..156 CDD:276811
PLN03218 <144..>284 CDD:215636
PPR 2 161..195
PPR repeat 164..191 CDD:276811
PPR 3 196..230
PPR repeat 199..226 CDD:276811
PPR 4 231..265
PPR repeat 232..261 CDD:276811
PPR 5 266..300
PPR repeat 267..296 CDD:276811
PPR 6 301..335 7/27 (26%)
PPR repeat 303..327 CDD:276811 4/14 (29%)
PPR 7 403..437 7/33 (21%)
PPR 8 438..472 8/33 (24%)
PPR 9 678..709 6/30 (20%)
PPR 10 710..746 9/38 (24%)
Interaction with BECN1 and Aedes aegypti venom allergen-1. /evidence=ECO:0000269|PubMed:31937766 712..1067 86/400 (22%)
PPR repeat 714..740 CDD:276811 8/28 (29%)
PPR repeat 746..777 CDD:276811 4/30 (13%)
PPR repeat 786..810 CDD:276811 8/31 (26%)
PPR repeat 1039..1061 CDD:276811 8/26 (31%)
LapB 1046..1311 CDD:442196 46/295 (16%)
PPR 16 1066..1102 5/35 (14%)
PPR repeat 1067..1098 CDD:276811 4/30 (13%)
PPR 17 1103..1137 9/53 (17%)
PPR repeat 1104..1128 CDD:276811 6/23 (26%)
RNA-binding 1121..1394 50/274 (18%)
ppr5NP_594649.2 PPR repeat 215..251 CDD:276811 10/41 (24%)
PPR_2 217..269 CDD:463778 12/60 (20%)
PPR_long 888..1064 CDD:407303 42/267 (16%)
PPR repeat 890..920 CDD:276811 8/48 (17%)
PPR_2 924..973 CDD:463778 8/48 (17%)
PPR repeat 926..955 CDD:276811 4/28 (14%)
PPR repeat 961..988 CDD:276811 8/49 (16%)
PPR repeat 1033..1064 CDD:276811 10/79 (13%)
PPR repeat 1117..1139 CDD:276811 2/5 (40%)
PPR repeat 1145..1174 CDD:276811
PPR repeat 1183..1210 CDD:276811
Blue background indicates that the domain is not in the aligned region.

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