DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LRPPRC and lrpr-1

DIOPT Version :10

Sequence 1:NP_573566.2 Gene:LRPPRC / 10128 HGNCID:15714 Length:1394 Species:Homo sapiens
Sequence 2:NP_001412560.1 Gene:lrpr-1 / 178978 WormBaseID:WBGene00015425 Length:996 Species:Caenorhabditis elegans


Alignment Length:1008 Identity:202/1008 - (20%)
Similarity:347/1008 - (34%) Gaps:249/1008 - (24%)


- Green bases have known domain annotations that are detailed below.


Human    34 LHAASYLPA-------ARAGPVAGGLLSPARLYAIAAKEKDIQEESTFSSRKISNQFDWALMRLD 91
            :.||:..|:       .|.|...|         .:|:|||:          :.||. |..|.|:.
 Worm    30 ISAATTFPSIEIDSKLVRRGDFRG---------VVASKEKN----------RASNP-DVVLSRIQ 74

Human    92 LSVRRTGRIPKKLLQKVFNDTCRSGGLGGSHAL------------LLLRSCGSLLPELKLEERTE 144
            .::|:..||...:   :..|..|....|..:.:            :|:..||..|..::...:.|
 Worm    75 ENLRKNYRISGDV---ILFDVVRQMESGNQNFIDHVVRSPERWIPMLIHGCGHSLSNIETASKNE 136

Human   145 FAHRIWDTLQKLGAVYDVSHYNALLKVYLQNEYKFSPTDFLAKMEEANIQPNRVTYQRLIASYCN 209
            ...|:|..||...|...|..:||..:|..:||..:.|...|..||.:.::|...|:..::.....
 Worm   137 ILERLWAQLQSKLAKVPVYAWNARFQVLNENEVDWDPLKELDNMERSGVEPTIETFHAVVKRISA 201

Human   210 VGDIEGASKILGFMKTKDLPV-----TEAVFSALVTGHARAGDMENAENILTVMRDAGIEPGPD- 268
            .||::|...::..|..|...|     ..:||:..:.||....|        ::...|..:.|.: 
 Worm   202 SGDVDGCKNMVYNMARKGFSVDAHINAASVFAFSIRGHYLKAD--------SLCEQASTKYGEEG 258

Human   269 ---TYLALLNAYAEKGDIDHVKQTLEKV---EKSELHLMDRDLLQIIFSFSK-------AGYPQY 320
               .:.|.:.|.|.:||.|.::|.|.|.   ...:|.|...|:|:.|:..::       |...|.
 Worm   259 SQLAHGAAVRAAACRGDNDRLRQVLRKSVIGSTKKLFLSSTDILETIWQMAEKSRDGKGAECSQL 323

Human   321 VSEIL-----------------EKVTCERRYIPDAMNLILLLVTEKLEDV-----------ALQI 357
            |.::|                 |:..|.|.|.   ..|.||..|:::.|.           .|..
 Worm   324 VEQMLNCTLRDSGFFRKLFREIERHICSRHYY---TALSLLEDTKRVSDCLENQRKNAFLHQLVG 385

Human   358 LLACPVSKEDGPSVFGSFFLQHCV---------TMNTPVEKL-----------------TDYCKK 396
            .|:..:.:...|:        |.:         |.|....||                 .|...:
 Worm   386 RLSTQLIRSHEPA--------HLIRDIANRVHFTFNNKYSKLKIRMYDDLLFATLMLKDMDLDDR 442

Human   397 LK-------EVQMHSFPLQFTLHCALLANKTDLAKALMKAVKEEGF---------PIRPHYFWPL 445
            |:       |:......:..||.........|...|::..:...|:         |:......||
 Worm   443 LRYFRSFVDEIDTRRERIHITLPLMTSEQNLDQRLAILYRLSTMGYRDWSSIENEPLVQIILQPL 507

Human   446 L-VGR--RKEKNVQGIIEILK--GMQELGV-----------------HPDQETYTDYVIPCFDSV 488
            . .||  |.:..:..:..|||  |:.|..|                 .|:::....|   ..|..
 Worm   508 YNSGRPFRNQSKLDKLARILKSYGISERQVWMILHRWSKQKAKQEAPQPEEQWSRPY---AKDLR 569

Human   489 NSARAILQE-----NGCLSDSDMFSQAGLRSEAANGNLDFVLSFLKSNTLPISL---QSIRSSLL 545
            ...||...|     ...:::|.......|:|....|::..|.|.|.||..|:..   :.:...|.
 Worm   570 GWCRAYYSETFESPKTTMNNSIPIPYEKLKSCVDQGDITKVSSVLCSNGWPVDTDFGEIVPPVLN 634

Human   546 LGFRRSMNINLWSEITELLYKDGRYCQEP-RGPTEAVGYFLYNLIDSMSDSEVQAKEEHLRQYFH 609
            |........|:.|.:.|:....|.:.::| :.|.:  .:.|.:::..|::.|.......:..|.:
 Worm   635 LYLMHESWKNVRSMLEEIAAFSGEWNEDPSKSPMK--NFHLLSVLRRMAEEEDTLSIRAITDYAY 697

Human   610 QL---------------------EKMNVKIPENIYRGIRNLLESYHVPELIKDAHLLVESKNLDF 653
            :|                     :|:.||..|.:.   |..|.:..|.|||.....||:   ||.
 Worm   698 ELRTLFPHATCYYEGFFETQTEYKKLFVKCFERLE---RQGLTTSTVDELIDFLRCLVK---LDL 756

Human   654 QKTVQLTSSELESTLETLKAENQPIRDVLKQLILVLCSEENMQKALELKAKYESDM-VTGGYAAL 717
               :||..||..:..                .|.:|.......:||....|:.|.: ...|..||
 Worm   757 ---IQLHPSESLTVF----------------FINILLKRLGWAEALSTWQKFLSSLHCPNGTVAL 802

Human   718 INLCCRHDKVEDALNLKEEFDRLDSSAVLDTGKYVGL-VRVLAKHGKLQDAINILKEMKEKDVLI 781
            :..|.:.:..|..:||:....|  .|..|...:...: ..||....|.:||.....::..|   :
 Worm   803 LRHCLQQNTDEARMNLQFVLHR--GSTFLSQSRMSAMHFAVLISMRKFEDAEKFCDQLSHK---V 862

Human   782 KDTTALSFFHMLNGAALRGEIETVKQLHEAIV---TLGLA---EPSTNISFPLVTVHLEKGDLST 840
            .....|....::|....| .::....|..|.:   .|||:   |.:.::...|:.:...:....|
 Worm   863 DPNDCLMAMRLMNSLKAR-SVDDQFMLDFAALCLRKLGLSDNKEVAQSMQADLLRICDTRHMGPT 926

Human   841 ALEVAIDCYEKYKVLPRIHDV--LCKLVEKGET 871
            ||.| .|.:.:|.|..|..:.  |..::||..|
 Worm   927 ALRV-YDLFSEYGVELREEEKNRLAAVIEKHST 958

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRPPRCNP_573566.2 PPR 1 126..160 10/33 (30%)
PPR repeat 126..156 CDD:276811 9/29 (31%)
PLN03218 <144..>284 CDD:215636 36/148 (24%)
PPR 2 161..195 10/33 (30%)
PPR repeat 164..191 CDD:276811 9/26 (35%)
PPR 3 196..230 6/33 (18%)
PPR repeat 199..226 CDD:276811 5/26 (19%)
PPR 4 231..265 6/33 (18%)
PPR repeat 232..261 CDD:276811 5/28 (18%)
PPR 5 266..300 11/40 (28%)
PPR repeat 267..296 CDD:276811 9/35 (26%)
PPR 6 301..335 10/57 (18%)
PPR repeat 303..327 CDD:276811 7/47 (15%)
PPR 7 403..437 5/42 (12%)
PPR 8 438..472 11/55 (20%)
PPR 9 678..709 6/30 (20%)
PPR 10 710..746 9/35 (26%)
Interaction with BECN1 and Aedes aegypti venom allergen-1. /evidence=ECO:0000269|PubMed:31937766 712..1067 38/169 (22%)
PPR repeat 714..740 CDD:276811 6/25 (24%)
PPR repeat 746..777 CDD:276811 6/31 (19%)
PPR repeat 786..810 CDD:276811 4/23 (17%)
PPR repeat 1039..1061 CDD:276811
LapB 1046..1311 CDD:442196
PPR 16 1066..1102
PPR repeat 1067..1098 CDD:276811
PPR 17 1103..1137
PPR repeat 1104..1128 CDD:276811
RNA-binding 1121..1394
lrpr-1NP_001412560.1 PPR repeat 189..218 CDD:276811 5/28 (18%)
PPR repeat 224..249 CDD:276811 5/32 (16%)
Blue background indicates that the domain is not in the aligned region.

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