DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNF263 and CG6654

DIOPT Version :9

Sequence 1:	NP_005732.2	Gene:	ZNF263 / 10127	HGNCID:	13056	Length:	683	Species:	Homo sapiens
Sequence 2:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster

Alignment Length:	667	Identity:	173/667 - (25%)
Similarity:	260/667 - (38%)	Gaps:	161/667 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    59 LSRLQEL--CHGW---LRPEMRTKEQILELLVLEQFLTILPQEIQSRV----------QELHPES 108
            ||.|.|:  |:.:   .....||..|:|.        ..||:|..|:|          |.:...|
  Fly    53 LSCLSEISNCYTFKIKCENSSRTLRQLLP--------NALPEEPDSKVSISCPVATTDQAVQTTS 109

Human   109 GE----------EAVTLVEDMQRELGRLRQQVT----NHGRGTEVLLEEPLPLETARESPSFKLE 159
            .|          :||| ..|.::....::..::    ..|.|.  :.:..||.|...::.|..|:
  Fly   110 WEPDRCTASVQTDAVT-TTDAEQNTSLIKSTISVDLDYEGEGE--VFDYELPDEPVEKTTSLILQ 171

Human   160 PMETERSPGPRLQELLGPSPQRDPQAVKERALSAPWLSLFPPEGNMEDKE---MTGPQLPESLED 221
            .....:.....:........:.|...::::..... |::|  ||...:.|   :|.||:......
  Fly   172 VQGNLKDEKEVVFTQTNVIYEGDDHELEQQIRECN-LAIF--EGVDNEAEIITVTAPQVTTRKSA 233

Human   222 VAMYISQEEWGHQDP--SK---RALSRDTVQESYENVDSLESHIPSQEVPGTQVGQGGKLWDPSV 281
            ..:...||...||.|  ||   |.|.::.|.:|.:.. |....:..|:||.|..
  Fly   234 AKLLTQQENDKHQTPVGSKEEARELEKEQVPQSAKRT-SRRRGVVKQDVPATPP----------- 286

Human   282 QSCKEGLSPRGPAPGEEKFENLEGVPSVCSENIHPQVLLPDQARGEVPWSPELGRPHDRSQGDWA 346
                   |...|:|.:.:                    |..|.:...|.:..:..|...|
  Fly   287 -------SDAEPSPKQHR--------------------LGTQRKLSAPRAGTVNGPSTTS----- 319

Human   347 PPPEGGMEQALAGASSGRELGRPKELQPKKLHLCPLCGKNFSNNSNLIRHQRIHAAERLCMG--- 408
                        ||::..||         |.| |..|...|:...:|:.|:|    ::.|:.
  Fly   320 ------------GAATTPEL---------KYH-CDRCNAGFAVEKSLMIHRR----QKGCINRNY 358

Human   409 --VDCTEIFGGNPRFLSLHRAHLGEEAHKCLECG-KCFSQNTHLTRHQ-RTHTGEKPYQCNICGK 469
              .:|.::| .:|..|:.|:|..|  ||.|.||| :|.|:.. |::|. :.|......|||||.|
  Fly   359 KCNECEKVF-VSPDHLAEHQASHG--AHNCPECGIRCDSKEA-LSKHMVQGHKRNLRNQCNICQK 419

Human   470 CFSCNSNLHRHQRTHTGEKPYKCPECGEIFAHSSNLLRHQRIHTGERPYKCPECGKSFSRSSHLV 534
            .|:..|.|..|.|.||||||:.|..||:.|..::||.:|:..|:..:.:||..|..||...:.|.
  Fly   420 VFTMLSTLRDHMRIHTGEKPFVCNICGKSFTQNANLRQHKLRHSETKSFKCELCPHSFVTKAELT 484

Human   535 IHERTHERERLYPFSECGEAVSDSTPFLTNHGAHKAEKKLFECLTCGKSFRQGMHLTRHQRTHTG 599
            .|.|||..:                             |.|||..|...|.....|.:|:|.|||
  Fly   485 SHARTHTGD-----------------------------KPFECEVCLARFTTSCSLAKHKRKHTG 520

Human   600 EKPYKCTLCGENFSHRSNLIRHQRIHTGEKPYTCHECGDSFSHSSNRIRHLRTHTGERPYKCSEC 664
            |:||.|.||...|:..:.|..|:|.||||:||.|..|..:|:...:...|.|||.|||.|.|..|
  Fly   521 ERPYACDLCPMRFTALNVLKNHRRTHTGERPYVCPFCSKTFTQRGDCQMHQRTHQGERIYICPVC 585

Human   665 GESFSRSSRLMSHQRTH 681
            .|.|.....:.||...|
  Fly   586 NEEFKSMPEMRSHLAGH 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF263	NP_005732.2	SCAN	38..149	CDD:128708	25/118 (21%)
		Dendrin	<128..>347	CDD:317849	40/230 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..185		4/37 (11%)
		KRAB	218..277	CDD:214630	16/63 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..301		17/75 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..368		8/45 (18%)
		C2H2 Zn finger	380..400	CDD:275368	6/19 (32%)
		zf-C2H2	380..400	CDD:306579	6/19 (32%)
		COG5048	<434..649	CDD:227381	76/216 (35%)
		C2H2 Zn finger	436..456	CDD:275368	8/21 (38%)
		C2H2 Zn finger	464..484	CDD:275368	10/19 (53%)
		C2H2 Zn finger	492..512	CDD:275368	7/19 (37%)
		C2H2 Zn finger	520..540	CDD:275368	7/19 (37%)
		C2H2 Zn finger	577..597	CDD:275368	6/19 (32%)
		C2H2 Zn finger	605..625	CDD:275368	7/19 (37%)
		COG5048	629..>682	CDD:227381	20/53 (38%)
		C2H2 Zn finger	633..653	CDD:275368	5/19 (26%)
		C2H2 Zn finger	661..681	CDD:275368	6/19 (32%)
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071	7/25 (28%)
		C2H2 Zn finger	331..354	CDD:275368	6/26 (23%)
		COG5048	<357..570	CDD:227381	84/245 (34%)
		C2H2 Zn finger	360..380	CDD:275368	6/20 (30%)
		C2H2 Zn finger	385..406	CDD:275370	8/21 (38%)
		C2H2 Zn finger	414..434	CDD:275368	10/19 (53%)
		zf-H2C2_2	427..451	CDD:290200	13/23 (57%)
		C2H2 Zn finger	442..490	CDD:275368	16/47 (34%)
		C2H2 Zn finger	470..487	CDD:275368	5/16 (31%)
		zf-H2C2_2	482..507	CDD:290200	11/53 (21%)
		C2H2 Zn finger	498..518	CDD:275368	6/19 (32%)
		zf-H2C2_2	510..534	CDD:290200	12/23 (52%)
		C2H2 Zn finger	526..546	CDD:275368	7/19 (37%)
		zf-H2C2_2	539..563	CDD:290200	12/23 (52%)
		C2H2 Zn finger	554..574	CDD:275368	5/19 (26%)
		C2H2 Zn finger	582..602	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910