Protein Alignment CDH13 and shg

DIOPT Version :10

• Sequence 1: NP_001207417.1
• Gene: CDH13 / 1012
• HGNCID: 1753
• Length: 760
• Species: Homo sapiens
• Sequence 2: NP_476722.1
• Gene: shg / 37386
• FlyBaseID: FBgn0003391
• Length: 1507
• Species: Drosophila melanogaster
• Alignment Length: 719
• Identity: 193/719 - (26%)
• Similarity: 318/719 - (44%)
• Gaps: 94/719 - (13%)

Human    44 SENGPQMPGRDPPAASTMQVLLLTSAEDL-DCTPGFQQKVFHINQPAEFIEDQSILNLTFSDC-K 106
            ::||  :|..|.  ..|..|.:    ||: |..|.|.:..:..:.......|..::.::.||. .
  Fly   168 TDNG--LPPLDD--VCTFNVTI----EDINDNAPAFNKARYDESMSENAQPDAVVMTISASDFDD 224

Human   107 GNDKL-RYEV----SSPYFKVNSDGGLVALRN--ITAVGKTLFVHARTPHAEDMAELVIVGGKDI 164
            ||:.| .||:    ...|||::.:.|::.|:.  ....|::..:..|..:        :|.....
  Fly   225 GNNSLVEYEILRERDFQYFKIDKESGIIYLKRPIDKRPGQSYAIIVRAYN--------VVPDPPQ 281

Human   165 QGSLQDIFKFARTSPVPRQKRSIVVSPILIPENQRQPFPRDVGKV-VDSDRPERSK--FRL-TGK 225
            ...::...:...:|..|....:.:.:||.:.||.:. |...:..: ..|:.|::.:  |.| ||:
  Fly   282 DAQIEVRIRVVESSIKPPSFVNPIDTPIYLKENLKN-FTHPIATLRAVSNMPDKPEVIFELNTGR 345

Human   226 GVDQEPKGIFRINE--NTGSVSVTRTLDREVIAVYQLFVETTDVNGKTLEGPVPLEVIVIDQNDN 288
            ......|..|..|:  |..::|:.:|||.|.|..|.|.:...:.:....|..:.::  |.|.|||
  Fly   346 TEQTNSKNTFVFNQIGNEVTISLGKTLDYEAITDYTLTMIVRNTHELGTEHQIKIQ--VEDVNDN 408

Human   289 RPIFREGPYIGHVMEGSPTGTTVMRMTAFDADDPATDNALLRYNIRQQTPDKPSPNMFYIDPEKG 353
            .|.:.| ...|.::|..|.||.||::.|||.|..:.:| ::.:.:..      :...|.|||..|
  Fly   409 IPYYTE-VKSGTILENEPPGTPVMQVRAFDMDGTSANN-IVSFELAD------NREYFTIDPNTG 465

Human   354 DIVTVVSPALLDRETLENPKYELIIEAQDMAG---LDVG--LTGTATATIMIDDKNDHSPKFTKK 413
            :|..:.:   .|||  |...|.:.:.|.|.:.   .|.|  ..|.....|.|.|||||.|.|.:.
  Fly   466 NITALTT---FDRE--ERDFYNVKVIASDNSPSSLFDNGEPNRGHQVFRISIGDKNDHKPHFQQD 525

Human   414 EFQA--TVEEGAVGV-IVNLTVEDKDDPTTGAWRAAYTIINGNPGQSFEIHTNPQTNEGMLSVVK 475
            ::.|  .:|:..... ::.:..||:|:    |.:..|:|.:||.|.:|:|    ....|.::|.:
  Fly   526 KYLAERLLEDANTNTEVIEVKAEDEDN----ASQILYSIESGNVGDAFKI----GLKTGKITVNQ 582

Human   476 PLDYEISAFHTLLIKVENEDPLVPDVSYGPSSTATVHITVLDVNEGPVFYPDPMMVTRQEDLSVG 540
            .||||....:.|  ||...|.:..|.:       ||.|.:.|||:.|..:.....||..|:.:..
  Fly   583 KLDYETITEYEL--KVRAFDGIYDDYT-------TVVIKIEDVNDNPPVFKQDYSVTILEETTYD 638

Human   541 SVLLTVNATDPDSLQH---QTIRYSVYK-DPAGWLNINPINGTVDTTAVLDRESPFVDNSVYTAL 601
            ..:|||.|.|||....   |.|.||::: |...|...|  :|.:.....|||:.| ..:..:..|
  Fly   639 DCILTVEAYDPDIKDRNADQHIVYSIHQNDGNRWTIDN--SGCLRLVKTLDRDPP-NGHKNWQVL 700

Human   602 FLAIDSGNPPATGTGT-------LLITLEDVNDNAPFIYPTVAEVCDDAKNLS-VVILGASDKDL 658
            ..|.|.     .|.||       :.:||:|:||||||:...:.....:.:|.. ||.|.|:|.|.
  Fly   701 IKANDE-----DGVGTTVSTVKEVTVTLKDINDNAPFLINEMPVYWQENRNPGHVVQLQANDYDD 760

Human   659 HPNTDPFKFEIHKQAVPDKVWKISKINN-THALVSLLQNLNKANYNLPIMVTDSGKPPMTNITDL 722
            .|....|.|.|..:|.||...|.|...: .||.|...:...| .|.:||.::|||.|..:.::.|
  Fly   761 TPGAGNFTFGIDSEATPDIKTKFSMDGDYLHANVQFDREAQK-EYFIPIRISDSGVPRQSAVSIL 824

Human   723 RVQV 726
            .:.:
  Fly   825 HLVI 828

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDH13	NP_001207417.1	Cadherin_pro	74..158	CDD:471661	17/91 (19%)
		CA	208..290	CDD:214520	24/87 (28%)
		Cadherin_repeat	296..406	CDD:206637	33/114 (29%)
		Cadherin	415..516	CDD:394985	27/103 (26%)
		Cadherin_repeat	535..628	CDD:206637	30/103 (29%)
		CA_like	636..727	CDD:481204	28/93 (30%)
shg	NP_476722.1	Cadherin_repeat	93..191	CDD:206637	8/30 (27%)
		Cadherin_repeat	200..292	CDD:206637	16/99 (16%)
		CA	332..410	CDD:214520	23/79 (29%)
		Cadherin_repeat	417..518	CDD:206637	33/112 (29%)
		Cadherin_repeat	531..619	CDD:206637	29/104 (28%)
		Cadherin_repeat	627..729	CDD:206637	32/109 (29%)
		Cadherin_repeat	736..834	CDD:206637	28/94 (30%)
		LamG	1127..1294	CDD:238058
		CADH_Y-type_LIR	1430..1489	CDD:460041