Protein Alignment HIPK3 and hipk3b

DIOPT Version :10

• Sequence 1: XP_047282179.1
• Gene: HIPK3 / 10114
• HGNCID: 4915
• Length: 1233
• Species: Homo sapiens
• Sequence 2: NP_001073628.1
• Gene: hipk3b / 569156
• ZFINID: ZDB-GENE-030131-82
• Length: 1261
• Species: Danio rerio
• Alignment Length: 1299
• Identity: 781/1299 - (60%)
• Similarity: 940/1299 - (72%)
• Gaps: 122/1299 - (9%)

Human    19 MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSCVFQERNYPRTYVNGRNFGNSHPPTKGSAFQTK 83
            ||||||||||:|:|||:|||||||||||||.:||:.||.||:||:|||..|.::|....::|:|:
Zfish     1 MASQVLVYPPHVFQTQTSAFCSVKKLKVEPRNCVYHERAYPQTYLNGRTLGIAYPTKLTASFKTR 65

Human    84 ---IPFNRPRGHNFSLQTSA-----------VVLKNTAGAT------------KVIAAQAQQAHV 122
               |..:  ||.:|.|||:|           |..:...||:            :|.::.|.:|..
Zfish    66 DSVIGIH--RGQDFPLQTAAVQGVRRQHTITVAQQQKRGASSQEKESEHQDKGRVCSSGATRAAG 128

Human   123 QAPQIGAWRNR--------------------------LHFLEGPQRCGLKRKSEELDNHSSAMQI 161
            :...:|:....                          ....:...||||||||.||:|..|.|||
Zfish   129 RGRGVGSDSQEEGGGGQGGVDEGGGGEDEGDQEDCGGFDLNDSSHRCGLKRKSGELENLGSTMQI 193

Human   162 VDELSILPAMLQTNMGNPVTVVTATTG---SKQ--NCTTGEGDYQLVQHEVLCSMKNTYEVLDFL 221
            |::||:||||||:|:|||...|....|   :||  ....|:|||||||||:|||:||||||||||
Zfish   194 VEDLSMLPAMLQSNVGNPPVAVPQAVGGGPAKQGGGSGNGDGDYQLVQHEMLCSLKNTYEVLDFL 258

Human   222 GRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADEYNFVRAYECFQHR 286
            ||||||||||||||||.:|||:|||||||||||||||||.||||||.|||||:|.|||:||||||
Zfish   259 GRGTFGQVVKCWKRGTKDIVAVKILKNHPSYARQGQIEVGILARLSNENADEHNLVRAFECFQHR 323

Human   287 NHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDP 351
            :|||||||||||||||||||||||||||||||||||||||||||||.:|||||||||||||||||
Zfish   324 SHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKGMGLIHADLKPENIMLVDP 388

Human   352 VRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPL 416
            ||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||
Zfish   389 VRQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPL 453

Human   417 YPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEA 481
            ||||||:|||||||||||||||.|||||||::||||:|:|..::.||||:.||||.|||:|||||
Zfish   454 YPGALEFDQIRYISQTQGLPGEHLLNVGTKTSRFFCRESDSPYATWRLKSTEEHETETGLKSKEA 518

Human   482 RKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMK 546
            |||||:.|||:||||.||:|||.||||||.||.|||:||||||||||:.||.|::.|:||||.|:
Zfish   519 RKYIFSCLDDIAHVNLVMNLEGCDLLAEKVDRAEFVALLKKMLLIDAEERIAPSDALSHPFVTMQ 583

Human   547 HLLDFPHSNHVKSCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTAT-LTANFTKIGTLRSQA 610
            |||||||||||||||||||:|.|...|.::::..|...:|.|.|:..|: ||..|.|:..:.:||
Zfish   584 HLLDFPHSNHVKSCFHIMDVCCSRPGSYESHSRTKAQFVRTVPSTGAASNLTLPFCKVTGIHTQA 648

Human   611 LTTSAHSVVHHGIPLQAGTAQFGCGDAFQQTLIICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQ 675
            |.:||.:|:|.|||||.|:|||  ||:|||.||:|||.|||:|....||..||:.:::|||||||
Zfish   649 LASSAPTVMHPGIPLQTGSAQF--GDSFQQALILCPPTIQGLPPNPNKPAGYSVSMESTVPLVTQ 711

Human   676 APAVQPLQIRPGVLSQT-WSGRTQQMLVPAWQQVT---PLAPATTTLTSESVAGSHRLGDWGKMI 736
            |.|:|||||||||::|. ||.|.||:|||.|.|||   |:||:.|||.||.|||..||.||||:.
Zfish   712 ASAIQPLQIRPGVITQQGWSNRAQQILVPTWPQVTPVAPVAPSATTLASEPVAGPQRLADWGKVH 776

Human   737 SCSNHYNSVMP--QPLLTNQITLSAPQPVSVGIAHVVWPQPATTKKNKQCQNRGILVKLMEWEPG 799
            |..|||:|:||  ||||||.:.:||.||:|:|||||||||||..|:||...||
Zfish   777 SHGNHYSSMMPHHQPLLTNPMAMSAHQPISIGIAHVVWPQPAANKRNKPSSNR------------ 829

Human   800 REEINAFSWSNSLQNTNIPHSAFISPKIIN-GKDVEE--VSCIETQDNQNSEGEARNCCETSIRQ 861
               .|.|..|.:.||.:..     |||::| .|:.||  ..|:...:::..:.|...||:.....
Zfish   830 ---CNNFMHSTNSQNVSCQ-----SPKMVNSAKNTEEEAADCVVEAESEAVQEEESVCCKAEPEY 886

Human   862 DSDSSVSDKQRQTIIIADSPSPAVSVITISSDTDEE-ETSQRHSLRECKGSLDCEACQSTLNIDR 925
            : |.:||.||||||:|.||||||.|:|:|||.|||: ..:|:|:| |||||.||||||||||::|
Zfish   887 E-DPTVSQKQRQTIVITDSPSPAGSIISISSGTDEDGPDTQKHAL-ECKGSPDCEACQSTLNMER 949

Human   926 MCSLSSPDSTLSTSSSG--QSSPSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGH-DSPFAESTF 987
            :|||||||||||||||.  |||.|||||||||||:|:||.||||||||.|.||.. ||||.|:|:
Zfish   950 VCSLSSPDSTLSTSSSASEQSSASPCKRPNSMSDDERESGCDTVDGSPASVSSSRADSPFLEATY 1014

Human   988 VEDTHENTELVSSADTET-KPAVCSVVVPPVELENGLNADEHMANT--DSICQPLIKGRSAPGR- 1048
            :.|.::|.:...|.:||: |..|.::||||:.::|     |.:..|  :..|.|  ||||...|
Zfish  1015 INDNNQNCKATGSTETESAKLPVRTMVVPPMRVQN-----EPVGRTVIEPSCPP--KGRSGSNRQ 1072

Human  1049 LNQPSAVGTRQQKLTSAF-----QQQHLNFSQVQHFGSGHQEWNGNFGHRRQQAYIPTSVTSNPF 1108
            |...:.:..||||.|.||     .||.| |.||||:||.|||||||:.|||.||:||.:|.|:.|
Zfish  1073 LPYSTLLVNRQQKSTPAFPPLQPPQQQL-FGQVQHYGSSHQEWNGNYSHRRPQAFIPPTVHSHTF 1136

Human  1109 TLSHGSPNHTA--VHAHLAGNTHLGGQPTLLPYPSSATLSSAAPVAHLLASPCTSRPMLQHPTYN 1171
            ||.||||.||.  ..:||..:.|.  ||.||.||.|..|.:.||:|||||||..:|..:..|.|.
Zfish  1137 TLPHGSPTHTTHPPQSHLGVHPHT--QPALLSYPPSGPLVTNAPMAHLLASPGATRNHVFQPAYG 1199

Human  1172 ISHPSG-IVHQVPVGLNPRLLPSPTIH-QTQYKPIFPPHSYIAASPAYTGFPLSPTKLSQYPYM 1233
            :|||:| ::|||.||:| ||||||||| |.|:||:|||||:| |||||.|||||||||:||||:
Zfish  1200 LSHPAGHLLHQVTVGIN-RLLPSPTIHPQGQFKPLFPPHSFI-ASPAYAGFPLSPTKLNQYPYV 1261

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HIPK3	XP_047282179.1	STKc_HIPK3	214..543	CDD:271131	285/328 (87%)
		MSCRAMM_ClfA	<832..1039	CDD:468110	113/215 (53%)
hipk3b	NP_001073628.1	STKc_HIPK3	251..580	CDD:271131	285/328 (87%)