Protein Alignment HIPK3 and Hipk

DIOPT Version :10

• Sequence 1: XP_047282179.1
• Gene: HIPK3 / 10114
• HGNCID: 4915
• Length: 1233
• Species: Homo sapiens
• Sequence 2: NP_001369036.1
• Gene: Hipk / 38070
• FlyBaseID: FBgn0035142
• Length: 1409
• Species: Drosophila melanogaster
• Alignment Length: 1277
• Identity: 473/1277 - (37%)
• Similarity: 607/1277 - (47%)
• Gaps: 341/1277 - (26%)

Human   185 ATTG--------SKQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIV 241
            ||:|        ||::.:..:|||||||||||.|:...||||:||||||||||||||||||:|||
  Fly   154 ATSGGHANTQPPSKRSSSGADGDYQLVQHEVLYSLSAEYEVLEFLGRGTFGQVVKCWKRGTSEIV 218

Human   242 AIKILKNHPSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQ 306
            ||||||||||||||||||||||:|||.|||||:|||||:|||||:||||||||||||||||||||
  Fly   219 AIKILKNHPSYARQGQIEVSILSRLSQENADEFNFVRAFECFQHKNHTCLVFEMLEQNLYDFLKQ 283

Human   307 NKFSPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK 371
            |||||||||.|||||:||.|||.|||.||||||||||||||||||||||||||||||||||||||
  Fly   284 NKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSK 348

Human   372 TVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLP 436
            |||:|||||||||||||||||||||||||||||||:||||||||||||:.|:|||||||||||||
  Fly   349 TVCNTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLP 413

Human   437 GEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDL 501
            .|.:||..:|:::||.::.|.::..|||||.|||||||..|||||||||||.|||:..||...||
  Fly   414 TEHMLNSASKTSKFFYRDVDSTYPFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDL 478

Human   502 EGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVKSCFHIMDI 566
            ||..|||||.|||||:.|||:||.||.:.|:||||.|||.|..:.||:|:.:.|:||:...:|::
  Fly   479 EGGQLLAEKTDRREFIDLLKRMLTIDQERRLTPAEALNHSFTRLTHLVDYVYCNNVKASVQMMEV 543

Human   567 CKSHLNSCDTNNHN---KTSLLRPVASSSTATLTANFTKIGTLRSQALTTSAHSVVHHGIPL-QA 627
            |:.      .:.|.   .::|:.....|||..:|.      |:.:| ||:....:|..|.|| ..
  Fly   544 CRR------GDFHTVQPASTLVTNFVPSSTENMTF------TINNQ-LTSQVQRLVRDGRPLAYE 595

Human   628 GTAQFGCG------------DAFQQTL---IICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQAP 677
            |..|...|            |:||..|   |:|||:.|.:|:    ||.:.:     |...|..|
  Fly   596 GLYQIYNGRSVARQYPQTRTDSFQHQLVSNILCPPSYQTMPS----PTKHVV-----VGSATMQP 651

Human   678 AVQPLQIRP------------------------------GVLSQTW--SGRTQQMLVPAWQQVTP 710
               |||:.|                              ||   .|  :|| |..|||:|.|..|
  Fly   652 ---PLQVPPQQYVNVPVPVSMVEPTSGQRMLLTNRVQASGV---AWPQTGR-QMALVPSWPQQAP 709

Human   711 ----LAPATTTLTSESVAGSHRLGDWGKMISCSNHYNSVMPQPLLTNQITLSAP-QPVSVGIAHV 770
                :..:|.....|.:...|.|.               :|:    |.:...:| ..::.|.::.
  Fly   710 AHSLIVDSTPLFNVEEIYPKHHLN---------------LPR----NDLKKESPAHHIAKGNSYR 755

Human   771 VWPQPATTKKNKQCQNRGILVKLMEWEPGREEI--------------------NAFSWSNSLQNT 815
            |   |...||..| |...:..::.|..|..::.                    |...:|.|..:.
  Fly   756 V---PRHEKKEHQ-QLSPVKKRVKESSPPHQQRYQRAAHVSPQYHAHHNCNYGNGSGYSASAGSV 816

Human   816 NIPHSAFISPKIINGKDV----EEVSCIETQDNQNSEGE--ARNCCETS------IRQDSDSSVS 868
             :..||..|..|:||...    ..|.....|...:|.|.  ..||....      :.|...:...
  Fly   817 -VASSAASSSNIVNGSSSSSHHHHVPVAHAQPYSSSSGHHIVSNCNANGGAGGAVVYQQPPAHAH 880

Human   869 DKQRQ----------------TIIIADSPSPAVSVITISSDTDE---------EETSQR-HSLRE 907
            .:..|                ||.|.|:||| .:|||||...||         ....|| |:..:
  Fly   881 QQHGQQPHPQSSQHPQHVKQPTITIHDTPSP-TAVITISDSEDEGGEAGGAQVPVLKQRAHAQSQ 944

Human   908 CKGSLDCEACQSTLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPT 972
            ..|||...|               |.|:.|.||:.|       :|:....::|:...:..|..|.
  Fly   945 TSGSLLQHA---------------PSSSCSRSSAHQ-------QPHPHPQQQQQQQINYGDHDPE 987

Human   973 SDSSGHDSPFAESTFVEDTHENTELVSSA--------DTETKPAVCSVV---VPPVELENGLNAD 1026
            .....|.:..|.:......|.:.:....|        ..:.:|....|:   .|.::.|.|.:..
  Fly   988 DARRRHHAAAAAAVGSPKHHHHQQQQQPAPPPQQQQQQYQPQPPPQQVLPQPQPSIKYEPGQSQK 1052

Human  1027 EH---MANTDSICQPLIKGRSAPGRLNQPSA------VGTRQQ------KLTSAFQQQ------- 1069
            :.   ||.::...||.:.        :|||:      :.|:|:      :..:|..||
  Fly  1053 KRILAMAQSECGYQPQVP--------SQPSSSASLPHIPTKQEPAEFYPEYAAAPPQQLDTKRSS 1109

Human  1070 ----------------------------------------HLNFSQVQHFGS------------- 1081
                                                    |...|......|
  Fly  1110 WAPTSSGSGVSALPLAHPKREAPSVAPISYVAPSVAPPLAHSKSSSASSSSSISAATAAAAAAAA 1174

Human  1082 ------GHQEWN-------------GNFGHRRQQAYIPTSVTSNPFTLSHGSPNHTAVHAHLAGN 1127
                  |...|.             |:.|........|:||..:|...|||.      |.|.||
  Fly  1175 AAAASVGPPSWGPPQVYRQPSQPPPGSVGLPGSTQPPPSSVAPHPHHHSHGH------HHHQAG- 1232

Human  1128 THLGGQPTLLPYPSSATLSSAAPVAHLLASPCTSRPMLQHPTYNISH--PSGIVHQVPVGLNPRL 1190
            |.|||.|           ||.|..|.|.........:.:.||..:|.  ||...      .|..:
  Fly  1233 TPLGGSP-----------SSTAAAALLQPDIYAQGDIYRRPTVFVSQAAPSYAY------ANRAV 1280

Human  1191 LPSPTIHQTQYKPIFPPH---SYIAASPAYTGF-PLSPTKLS 1228
            :..|..|.:..:.:.|.|   ::|.....|:.| ||||.:::
  Fly  1281 VAPPPAHNSSSRQVIPSHPLPAHIQIPTQYSQFGPLSPAQVA 1322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HIPK3	XP_047282179.1	STKc_HIPK3	214..543	CDD:271131	269/328 (82%)
		MSCRAMM_ClfA	<832..1039	CDD:468110	51/258 (20%)
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	269/327 (82%)
		PHA03378	<1080..1327	CDD:223065	50/267 (19%)