DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HIPK3 and CG7028

DIOPT Version :9

Sequence 1:	NP_005725.3	Gene:	HIPK3 / 10114	HGNCID:	4915	Length:	1215	Species:	Homo sapiens
Sequence 2:	NP_001286884.1	Gene:	CG7028 / 38032	FlyBaseID:	FBgn0027587	Length:	912	Species:	Drosophila melanogaster

Alignment Length:	426	Identity:	134/426 - (31%)
Similarity:	202/426 - (47%)	Gaps:	61/426 - (14%)

- Green bases have known domain annotations that are detailed below.

Human   125 CGLKRKSEELDNHSSAMQIVD-----ELSILPAMLQTNM---GNPVTVVTATTGSKQNCTTGEGD 181
            |..|.|..|.|  ..|.|.||     ...|.|..:..|.   .||...        .|....||.
  Fly   525 CSAKEKRNEWD--MFADQDVDSNFDVSRKISPNTIVQNKHQHENPALT--------DNWDDAEGY 579

Human   182 YQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEI-----VAIKILKNHPSYARQGQIE 241
            |::...|||   .|.|.|..:.|:|.|..||    ||.::.     |||||::|:....:.|..|
  Fly   580 YRVRIGEVL---DNRYLVNGYTGQGVFSNVV----RGRDQARGQANVAIKIIRNNEIMHKTGLRE 637

Human   242 VSILARLS-TENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQ-NKFSPLPLKVIRPILQ 304
            :.||.:|: .:..|.::.:|.|..|.|:.|.|:|||.|..||.:.||: .|...|.:|.:|...|
  Fly   638 LEILKKLNDADPEDRFHCLRLYRHFFHKQHLCMVFEPLAMNLREVLKKYGKNVGLHIKAVRSYTQ 702

Human   305 QVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPE 369
            |:..|||.||..|::|||:||:||::.:   ....:|:.||||||.:|....:.||.||:||:||
  Fly   703 QLFLALKLLKKTGILHADIKPDNILVNE---NNLILKLCDFGSASAISDNEITPYLVSRFYRSPE 764

Human   370 IILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFC 434
            ||||:|:...||.||.||.|.||:.|..|:.|......:::....:|....:::..|....:.|.
  Fly   765 IILGIPYDYGIDTWSAGCTIYELYTGKILFSGKSNNQMLKFFMDVKGKIPNRIIRKGQFREQHFD 829

Human   435 KETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEK---ADRR 496
            :..:..:          ||.:   |..|..|.:...:     |.....|: .:|:|::   .|:.
  Fly   830 QSCNFLY----------HEID---KLTEREKIVVMPV-----VKPSRSLQ-QELIADQNLPDDQH 875

Human   497 EFVS----LLKKMLLIDADLRITPAETLNHPFVNMK 528
            ..|:    ||:.|..:|...||:..:.|.|||:..|
  Fly   876 RKVTQLKDLLENMFALDPAKRISLNQALVHPFIQEK 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HIPK3	NP_005725.3	STKc_HIPK3	196..525	CDD:271131	110/342 (32%)
		S_TKc	197..525	CDD:214567	110/341 (32%)
		Interaction with AR. /evidence=ECO:0000250	767..944
		Interaction with FAS. /evidence=ECO:0000250	796..891
		Required for localization to nuclear speckles. /evidence=ECO:0000250	855..1011
		SUMO interaction motifs (SIM), required for nuclear localization and kinase activity. /evidence=ECO:0000250	866..918
		Interaction with UBL1. /evidence=ECO:0000305	870..880
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	912..987
CG7028	NP_001286884.1	STKc_PRP4	591..908	CDD:271037	110/342 (32%)
CG7028	NP_001286884.1	S_TKc	599..908	CDD:214567	108/334 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810