Protein Alignment HIPK3 and Dyrk2

DIOPT Version :10

• Sequence 1: XP_047282179.1
• Gene: HIPK3 / 10114
• HGNCID: 4915
• Length: 1233
• Species: Homo sapiens
• Sequence 2: NP_001260456.1
• Gene: Dyrk2 / 34831
• FlyBaseID: FBgn0016930
• Length: 757
• Species: Drosophila melanogaster
• Alignment Length: 717
• Identity: 186/717 - (25%)
• Similarity: 302/717 - (42%)
• Gaps: 128/717 - (17%)

Human    55 ERNYPRTYVNGRNFGNSHPPTKGSAFQTKIPFNRPRGHNFSLQTSAVVLKNTAG------ATKVI 113
            |.....|.:||...||.:.             |....:|.....|:....::.|      :||..
  Fly    85 ENTVTTTSLNGNGNGNGNS-------------NSNNNNNIGSPVSSSTTNSSNGGNERGSSTKSN 136

Human   114 AAQAQ-QAHVQAPQIGAWRNRLHFLEGPQRCGLKRKSEEL---------DNHSSAMQIVDELSIL 168
            ::... .:...|...|:         |..:|.......||         |.....:::..|:...
  Fly   137 SSSGSGSSGNSASSTGS---------GELKCNTPMTPSELVKKFRNYLTDLEFEELKVYKEVWYF 192

Human   169 PAMLQTNMGNPV-TVVTATTGSKQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKC 232
            ......|...|. |..|...|...:    .|:|::::|:.:..   .||:|:.:|:|:||||::.
  Fly   193 GQHASKNYNKPAPTANTTNLGYDDD----NGNYKIIEHDHIAF---RYEILEVIGKGSFGQVIRA 250

Human   233 WKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENAD-EYNFVRAYECFQHRNHTCLVFEML 296
            ....||..|||||::|...:..|..:|::||..|..::|| .:|.:...:....|.|.|:.||::
  Fly   251 LDHKTNTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELM 315

Human   297 EQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVI 361
            ..|||:.:|:|.::...:.:||.....:...|:.|....:||.|||||||:|..  |....:|||
  Fly   316 SLNLYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILLKQ--RGSSSIKVI 378

Human   362 DFGSASHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQI 426
            ||||:.:|.:.: .||:|||:||:||:||||.:..|||||||||::|||:.|:||:||..|.:|:
  Fly   379 DFGSSCYVDRKI-YTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFPLFPGENEVEQL 442

Human   427 RYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDD 491
            ..|.:..|||.:.|::|..:...||                :..:|...:.:.:.||....| ..
  Fly   443 ACIMEVLGLPPKVLISVARRRRLFF----------------DSRDAPRCITNTKGRKRSPGS-KS 490

Human   492 VAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNH 556
            :||:....|             |.|:..|::.|..|...|:||.|..:|.|     |.....|.|
  Fly   491 LAHILHCQD-------------RYFIDFLQRCLEWDPAERMTPDEAAHHEF-----LQPSASSRH 537

Human   557 VKSCFHIMDICKSHLN------SCDTNNHNKTSLLRPVASSSTATLTANFTKIGTL---RSQALT 612
             :||........|.||      ||.:.:........||.:|.|:|...:...|.|.   |.|..:
  Fly   538 -RSCRMSSSSSSSGLNSVSQKSSCYSFSEISPGTNGPVVASITSTTAVHNAAIATTTKSRQQPPS 601

Human   613 TS-AHSVVHHGIPLQAGTAQFGCGDAFQQTLIICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQA 676
            .| .|:..:..:|    ..:....|.:.        ::|.: |...|.||          .|:..
  Fly   602 QSHGHAQSNGHLP----DIKLSASDKYN--------SMQKV-AVRSKITS----------SVSDL 643

Human   677 PAVQPLQIRPGVLSQTWSGRTQQMLVPAWQQVTPLAPATTTLTSESVAGSHRLGDWGKMISCSNH 741
            .:||...:. .:.....||.|..:...|.::..|       .|...:.|: ....:|......||
  Fly   644 ESVQQYSLH-RIYGGVGSGSTHHVSSAATRKHLP-------GTGSGIVGA-MSSKYGSSTLAHNH 699

Human   742 YN 743
            :|
  Fly   700 HN 701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HIPK3	XP_047282179.1	STKc_HIPK3	214..543	CDD:271131	115/329 (35%)
		MSCRAMM_ClfA	<832..1039	CDD:468110
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	125/387 (32%)