DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HIPK3 and mnb

DIOPT Version :9

Sequence 1:	NP_005725.3	Gene:	HIPK3 / 10114	HGNCID:	4915	Length:	1215	Species:	Homo sapiens
Sequence 2:	NP_728107.2	Gene:	mnb / 32771	FlyBaseID:	FBgn0259168	Length:	1047	Species:	Drosophila melanogaster

Alignment Length:	953	Identity:	245/953 - (25%)
Similarity:	367/953 - (38%)	Gaps:	221/953 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    94 VIAAQ------AQQAHVQAPQIGAWRNRLHFLEGPQRCGLKRKSEELDNHSSAMQIVDELSILPA 152
            |.|||      .:|.|  ||..|      .|::...   |.....::.:|.|:.....|:..:.|
  Fly   169 VDAAQGSGSGGGRQRH--APLYG------RFVDAED---LPATHRDVMHHHSSPSSSSEVRAMQA 222

Human   153 MLQTNMGNPVT-------------------VVTATTGSKQNCTTGEGD-------------YQLV 185
            .:..:...|.:                   |..|....:...|.|:.|             |...
  Fly   223 RIPNHFREPASGPLRKLSVDLIKTYKHINEVYYAKKKRRAQQTQGDDDSSNKKERKLYNDGYDDD 287

Human   186 QHEVLCSMKN------TYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSI 244
            .|:.:  :||      .||:...:|:|:||||||.:.......|||||:||...:..|.||||.:
  Fly   288 NHDYI--IKNGEKFLDRYEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKL 350

Human   245 LARLSTENAD-EYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVAT 308
            |..::..:|: :|..|:....|..|||.|||||:|..||||.|:...|..:.|.:.|...||:.|
  Fly   351 LEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCT 415

Human   309 ALKKLKS--LGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEII 371
            ||..|.:  |.:||.|||||||:|.:|.|.  .:|::||||:..:.:.:.. |:|||:||:||::
  Fly   416 ALLFLSTPELNIIHCDLKPENILLCNPKRS--AIKIVDFGSSCQLGQRIYH-YIQSRFYRSPEVL 477

Human   372 LGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKE 436
            ||:.:..|||||||||::.|:..|.||:.|..|.||:..|.:..|:|.:.||:...|:.:||.|
  Fly   478 LGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDK- 541

Human   437 TDMSHSGWRLKTLEEHEAETGMKSKEARKYI---FNSLDDVAHVNT------VMDLEGSDLLAEK 492
             .::...:.||           |::..|||.   ...|.|:..|.|      .:|..|..:
  Fly   542 -IVADGSYVLK-----------KNQNGRKYKPPGSRKLHDILGVETGGPGGRRLDEPGHSV---- 590

Human   493 ADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVKSCFHIMDICKSHLNSCD 557
            :|..:|..|:.:||..|...|:||...|.|.|  .|...|
  Fly   591 SDYLKFKDLILRMLDFDPKTRVTPYYALQHNF--FKRTAD------------------------- 628

Human   558 TNNHNKTSLLRPVASSSTATLTANFTKIGTLRSQALTTSAHSVVHHGIPLQAGTAQFGCGDAFQQ 622
                       ...::|.|..|||....|:..|.|..:|...|   |..|.|..:..|   |...
  Fly   629 -----------EATNTSGAGATANAGAGGSGSSGAGGSSGGGV---GGGLGASNSSSG---AVSS 676

Human   623 TLIICPPAIQGIPATHGKPTSYS--------IRVDNTVPLVTQAPAVQPLQIRPGVLSQTWSGRT 679
            :....|.|........|...|.|        .:....:||....|...|....||..|   .|:.
  Fly   677 SSAAAPTAATAAATAAGSSGSGSSVGGGSSAAQQQQAMPLPLPLPLPLPPLAGPGGAS---DGQC 738

Human   680 QQMLVPAWQQVTPLAPATTTLTSESVAGSHRLGDWGKMISCSNHYNSVMPQPLLTNQITLSAPQP 744
            ..:|:                  .||| ::.:.::..:...||.:    |.|.|.|    |....
  Fly   739 HGLLM------------------HSVA-ANAMNNFSALSLQSNAH----PPPSLAN----SHHST 776

Human   745 VSVG-IAHVVWPQPATT---KKNKQCQNRGILVKLMEWEPGREEINAFSWSNSLQNTN-----IP 800
            .|:| :.|:   .|.:|   ..|....|.......:.   |...:|.....||..:.|     .|
  Fly   777 NSLGSLNHI---SPGSTGCHNNNSNSSNNNTRHSRLY---GSNMVNMVGHHNSGSSNNHNSISYP 835

Human   801 HSAFISPKII-----NGKDVEEVSCI-ETQDNQ---NSEGEARNCCETSIRQDSDSSVSDKQRQT 856
            |:....|..:     ||.....|..| :.|.|.   ||.....|...:|:...:.::.:....
  Fly   836 HAMECDPPQMPPPPPNGHGRMRVPAIMQLQPNSYAPNSVPYYGNMSSSSVAAAAAAAAAAASH-- 898

Human   857 IIIADSPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQSTLNIDRMCSL--SSPDSTLS 919
            :::.||     |||:.|:...              |.......|:.:.......|  |.|..||.
  Fly   899 LMMTDS-----SVISASAAGG--------------GQGGGNPGQNPVTPSAAAFLFPSQPAGTLY 944

Human   920 TSSSGQSSPSPCKRPNSMSDEEQ---ESSCDTVDGSPTSDSSG 959
            .::.|..|..|...|..||...|   .||.....||.:..|.|
  Fly   945 GTALGSLSDLPLPMPLPMSVPLQLPPSSSSSVSSGSASVGSGG 987

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HIPK3	NP_005725.3	STKc_HIPK3	196..525	CDD:271131	127/340 (37%)
		S_TKc	197..525	CDD:214567	127/339 (37%)
		Interaction with AR. /evidence=ECO:0000250	767..944		39/195 (20%)
		Interaction with FAS. /evidence=ECO:0000250	796..891		20/108 (19%)
		Required for localization to nuclear speckles. /evidence=ECO:0000250	855..1011		26/110 (24%)
		SUMO interaction motifs (SIM), required for nuclear localization and kinase activity. /evidence=ECO:0000250	866..918		9/53 (17%)
		Interaction with UBL1. /evidence=ECO:0000305	870..880		2/9 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	912..987		17/51 (33%)
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	132/362 (36%)
mnb	NP_728107.2	S_TKc	303..623	CDD:214567	128/341 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840