Protein Alignment HIPK3 and hpk-1

DIOPT Version :10

• Sequence 1: XP_047282179.1
• Gene: HIPK3 / 10114
• HGNCID: 4915
• Length: 1233
• Species: Homo sapiens
• Sequence 2: NP_741761.1
• Gene: hpk-1 / 180695
• WormBaseID: WBGene00001994
• Length: 846
• Species: Caenorhabditis elegans
• Alignment Length: 886
• Identity: 364/886 - (41%)
• Similarity: 459/886 - (51%)
• Gaps: 170/886 - (19%)

Human    73 PPTKGSAFQTKIPFNRPRGHNFSLQ----TSAVVLKNTAGATKVIAAQAQQAHVQ-APQIGAWRN 132
            |..|.|...|.:....|:..:.:|:    ..|:::::....|    |.|....:| ||...:
 Worm     2 PKRKNSGQSTDLNSRSPKTIDEALRILAPPQALLVQSQLNLT----APANPFSIQKAPGTSS--- 59

Human   133 RLHFLEGPQRCGLKRKSEE---------LDNHSSAMQIVDELSILPAMLQTN--MGNPVTVVTAT 186
                 :..||...:|..||         |...|:..:.|  :...||:...|  |.......||.
 Worm    60 -----DNEQRAPKRRADEEAVNAVPKNLLTTSSTFARAV--IPAAPAISSANNKMAPQSVTATAK 117

Human   187 TGSKQNCTTGEGDYQLVQHEVLCS-MKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHP 250
            |.:.:...:|||:|||:::||||| ..|.||||:|||:||||||||.||:||:|||||||||.||
 Worm   118 TTTNRGKVSGEGEYQLIKNEVLCSPYGNQYEVLEFLGKGTFGQVVKAWKKGTSEIVAIKILKKHP 182

Human   251 SYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLK 315
            |||||||||||||:|||.||::|:|||||:|||.|::||||||||||||||||||||||.||||.
 Worm   183 SYARQGQIEVSILSRLSNENSEEFNFVRAFECFNHKSHTCLVFEMLEQNLYDFLKQNKFMPLPLN 247

Human   316 VIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQS 380
            .|||||.||.|||.||||||||||||||||||||||.:|||||||||||||||.||.|.:|||||
 Worm   248 AIRPILFQVLTALLKLKSLGLIHADLKPENIMLVDPQQQPYRVKVIDFGSASHRSKAVTNTYLQS 312

Human   381 RYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGT 445
            ||||||||||||||.|:||||||||||||||||||||||:.||||||:|.||||||...:|...:
 Worm   313 RYYRAPEIILGLPFNESIDMWSLGCVIAELFLGWPLYPGSSEYDQIRFIIQTQGLPPTSMLESAS 377

Human   446 KSTRFFCKE--------TDMSHSGWRLKTLEEHEAETG-MKSKEARKYIFNSLDDVAHVNTVMDL 501
            |..||| ||        |::..|.:||||:||:||.:. .||||.||||||.:||::.|....:.
 Worm   378 KLHRFF-KEVKSESPNHTNVGGSYYRLKTVEEYEASSSTAKSKETRKYIFNVIDDISRVCYGFES 441

Human   502 EGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVKSCFHIMDI 566
            :..:.|.::.||:|||.:|||||:::.|.||||||.|...||.|.|:..:..:|:|......|:|
 Worm   442 DPVEHLCDRIDRQEFVDVLKKMLVLNPDFRITPAEGLESKFVTMTHINGYNFANYVHEAHKRMEI 506

Human   567 CKSHLNSCDT--NNHNKTSLLRPVASSSTATLTANFTKIGTLRSQALTTSAHSV---------VH 620
            |:....:..|  ...|..:.:.||.......|......:....:|...|:...|         :|
 Worm   507 CRKPGPAMATPYRAANVATPITPVEKPPAPKLQQPMIAVLPQLNQIAATNIPPVPTQPDLTNLMH 571

Human   621 HGIPLQAGT------AQFGCGDAFQQTLIICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQAPAV 679
            |...:.|.|      |||     |.|.|   |||                      ||...|...
 Worm   572 HYSQMAAATGSAATAAQF-----FYQPL---PPA----------------------PLFQYAQLH 606

Human   680 QPLQIRPGVLSQTWSGRTQQMLVPAWQQVTPLAPATTTLTSESVAGSHRLGDW--GKMISCSNHY 742
            .|...||   ....|..|...:||.:..|..:.|            |...|.|  |.....:...
 Worm   607 HPFAARP---PHFLSLATPSHMVPQFVPVPIMDP------------SMLQGQWPPGAAQQFAVLA 656

Human   743 NSVM--PQPLLTNQITLSAPQPVSVGIAHVVWPQ-------PATTKKNKQCQNRGILVKLMEWEP 798
            |.:|  |.|...||:..|.||..|:       ||       .|||..|....|          .|
 Worm   657 NDIMRVPAPQGINQMFASTPQTFSL-------PQFLSSSIPSATTAFNGNAPN----------IP 704

Human   799 GREEINAFSWSNSLQNTNIPHSAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCETSIRQDS 863
            ..||.::::...:.|...  ..|..:..:|||.  .:|..:..|..:|
 Worm   705 FPEENSSWALGTAAQQQQ--QQAQRAQSMINGN--VKVKPLAAQPKKN----------------- 748

Human   864 DSSVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSQRHS 904
                              |||.||||:|||.|.......:|
 Worm   749 ------------------SPAPSVITLSSDEDSNGAGSSNS 771

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HIPK3	XP_047282179.1	STKc_HIPK3	214..543	CDD:271131	238/337 (71%)
		MSCRAMM_ClfA	<832..1039	CDD:468110	15/73 (21%)
hpk-1	NP_741761.1	Protein Kinases, catalytic domain	147..483	CDD:473864	238/336 (71%)
		Atrophin-1	<498..>758	CDD:460830	75/360 (21%)