Protein Alignment HIPK3 and Hipk3

DIOPT Version :10

• Sequence 1: XP_047282179.1
• Gene: HIPK3 / 10114
• HGNCID: 4915
• Length: 1233
• Species: Homo sapiens
• Sequence 2: NP_034564.2
• Gene: Hipk3 / 15259
• MGIID: 1314882
• Length: 1192
• Species: Mus musculus
• Alignment Length: 1216
• Identity: 1081/1216 - (88%)
• Similarity: 1131/1216 - (93%)
• Gaps: 25/1216 - (2%)

Human    19 MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSCVFQERNYPRTYVNGRNFGNSHPPTKGSAFQTK 83
            |||||||||||||||||||||||||||||||.||||||.||:.:|||||||||||.|||||||||
Mouse     1 MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSGCVFQERTYPQIHVNGRNFGNSHPSTKGSAFQTK 65

Human    84 IPFNRPRGHNFSLQTSAVVLKNTAGATKVIAAQAQQAHVQAPQIGAWRNRLHFLEGPQRCGLKRK 148
            |||.:||||:||||..|:|:|:|||||||:|||||||.|:||:...|||||||||||||||||||
Mouse    66 IPFTKPRGHSFSLQAGAIVVKDTAGATKVLAAQAQQAGVEAPRAVVWRNRLHFLEGPQRCGLKRK 130

Human   149 SEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTTGEGDYQLVQHEVLCSMKN 213
            ||||:|||.|||||||||||||||||||||||||||||||||||||:||||||||||||||||||
Mouse   131 SEELENHSGAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTSGEGDYQLVQHEVLCSMKN 195

Human   214 TYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADEYNFVR 278
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 TYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADEYNFVR 260

Human   279 AYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKSLGLIHADLKP 343
            |||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||||||||
Mouse   261 AYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPVLQQVATALKKLKSLGLIHADLKP 325

Human   344 ENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIA 408
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   326 ENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIA 390

Human   409 ELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAE 473
            ||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||
Mouse   391 ELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCRETDMSHSGWRLKTLEEHEAE 455

Human   474 TGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETL 538
            ||||||||||||||||||:.||||||||||.|||||||||||||:||||||||||||||||.|||
Mouse   456 TGMKSKEARKYIFNSLDDIVHVNTVMDLEGGDLLAEKADRREFVNLLKKMLLIDADLRITPIETL 520

Human   539 NHPFVNMKHLLDFPHSNHVKSCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANFTKI 603
            |||||||||||||||||||||||||||||||. :||:||||:|.||||||||:.||.|.|||||:
Mouse   521 NHPFVNMKHLLDFPHSNHVKSCFHIMDICKSP-SSCETNNHSKMSLLRPVASNGTAALAANFTKV 584

Human   604 GTLRSQALTTSAHSVVHHGIPLQAGTAQFGCGDAFQQTLIICPPAIQGIPATHGKPTSYSIRVDN 668
            |||||||||||||||||||||||||||||||||||.|||||||||||||||.|||||||||||||
Mouse   585 GTLRSQALTTSAHSVVHHGIPLQAGTAQFGCGDAFHQTLIICPPAIQGIPAAHGKPTSYSIRVDN 649

Human   669 TVPLVTQAPAVQPLQIRPGVLS-QTWSGRTQQMLVPAWQQVTPLAPATTTLTSESVAGSHRLGDW 732
            |||||||||||||||||||||| |||||||||||:||||||||:|||..|||||.:|||.|||||
Mouse   650 TVPLVTQAPAVQPLQIRPGVLSQQTWSGRTQQMLIPAWQQVTPMAPAAATLTSEGMAGSQRLGDW 714

Human   733 GKMISCSNHYNSVMPQPLLTNQITLSAPQPVSVGIAHVVWPQPATTKKNKQCQNRGILVKLMEWE 797
            ||||..|||||||||.||||||||||||||:|||||||||||||||||||.||||
Mouse   715 GKMIPHSNHYNSVMPPPLLTNQITLSAPQPISVGIAHVVWPQPATTKKNKLCQNR---------- 769

Human   798 PGREEINAFSWSNSLQNTNIPHSAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCETSIRQD 862
                       ||||||||||||||||||||:||:||||||::||||..|||||..|.|.|:||
Mouse   770 -----------SNSLQNTNIPHSAFISPKIISGKEVEEVSCVDTQDNHTSEGEAGTCREASVRQ- 822

Human   863 SDSSVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQSTLNIDRMC 927
             ||||||||||||||||||||||||||||||:|:||||.|.||||||||||||||||||||||||
Mouse   823 -DSSVSDKQRQTIIIADSPSPAVSVITISSDSDDEETSPRPSLRECKGSLDCEACQSTLNIDRMC 886

Human   928 SLSSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGHDSPFAESTFVEDTH 992
            ||||||||||||||||||||||||||||||:||||.|:|||||||||||||||||||::||||.|
Mouse   887 SLSSPDSTLSTSSSGQSSPSPCKRPNSMSDDEQESGCETVDGSPTSDSSGHDSPFAENSFVEDAH 951

Human   993 ENTELVSSADTETKPAVCSVVVPPVELENGLNADEHMANTDSICQPLIKGRSAPGRLNQPSAVGT 1057
            :||||.:.|..|.||||.:.|.|||..|:||:.|||||||||.||||.||:.|||:|:||.|:|.
Mouse   952 QNTELGTCAGPEAKPAVGTAVEPPVGRESGLSVDEHMANTDSTCQPLRKGQPAPGKLHQPPALGA 1016

Human  1058 RQQKLTSAFQQQHLNFSQVQHFGSGHQEWNGNFGHRRQQAYIPTSVTSNPFTLSHGSPNHTAVHA 1122
            ||||..:||.|||||.|||||||:|||||||||||||||||||||||||||||||||||||||||
Mouse  1017 RQQKPAAAFPQQHLNLSQVQHFGTGHQEWNGNFGHRRQQAYIPTSVTSNPFTLSHGSPNHTAVHA 1081

Human  1123 HLAGNTHLGGQPTLLPYPSSATLSSAAPVAHLLASPCTSRPMLQHPTYNISHPSGIVHQVPVGLN 1187
            ||||:||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||:|
Mouse  1082 HLAGSTHLGGQPTLLPYPSSASLSSAAPVAHLLASPCTSRPMLQHPTYNISHPSGIVHQVPVGIN 1146

Human  1188 PRLLPSPTIHQTQYKPIFPPHSYIAASPAYTGFPLSPTKLSQYPYM 1233
            ||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1147 PRLLPSPTIHQTQYKPIFPPHSYIAASPAYTGFPLSPTKLSQYPYM 1192

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HIPK3	XP_047282179.1	STKc_HIPK3	214..543	CDD:271131	321/328 (98%)
		MSCRAMM_ClfA	<832..1039	CDD:468110	167/206 (81%)
Hipk3	NP_034564.2	Protein Kinases, catalytic domain	196..525	CDD:473864	321/328 (98%)
		Interaction with AR. /evidence=ECO:0000250	767..921		137/176 (78%)
		Interaction with FAS. /evidence=ECO:0000269|PubMed:11034606	775..868		77/94 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	799..829		20/31 (65%)
		Required for localization to nuclear speckles. /evidence=ECO:0000250	832..988		129/155 (83%)
		SUMO interaction motifs (SIM), required for nuclear localization and kinase activity. /evidence=ECO:0000250	843..895		47/51 (92%)
		Interaction with UBL1. /evidence=ECO:0000250	847..857		7/9 (78%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	889..943		50/53 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	956..1023		41/66 (62%)