DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF20A and pav

DIOPT Version :9

Sequence 1:	NP_005724.1	Gene:	KIF20A / 10112	HGNCID:	9787	Length:	890	Species:	Homo sapiens
Sequence 2:	NP_477025.1	Gene:	pav / 38515	FlyBaseID:	FBgn0011692	Length:	887	Species:	Drosophila melanogaster

Alignment Length:	926	Identity:	241/926 - (26%)
Similarity:	407/926 - (43%)	Gaps:	191/926 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    46 VSTSLEDKQQVPSEDSMEKVKVYLRVRPLLPSELERQEDQGCVRIENVETLVLQAPKDSFALKSN 110
            |..::|.:::..|:.:.:.|.|:.||||     |:...|...:|::|..|:.|. |:|.......
  Fly    18 VHQTVEKQRRDTSDKARDPVNVFCRVRP-----LQSDADLTSLRVKNSTTIALN-PQDQLLQHHK 76

Human   111 ERGIGQATHRFTFSQIFGPEVGQASFFNLTVKEMVKDVLKGQNWLIYTYGVTNSGKTHTIQGTIK 175
            .....|...::.|..:|.|:..|...:....:.:|:::|||:|.|::|||||.||||:|:.|.::
  Fly    77 PHNGAQREVQYIFKHVFQPDATQQDVYAAVAQPLVENLLKGRNSLLFTYGVTGSGKTYTMTGNLR 141

Human   176 DGGILPRSLALIFNSLQGQLHPTPDLKPLLSNEVIWLDSKQIRQEEMKKLSLLNGG--LQEEELS 238
            ..||:||.|.::|.::                      |....::.:.|...|||.  |.||:
  Fly   142 HRGIMPRCLDVLFRTI----------------------SDYQAKKFVFKPDKLNGFEILSEED-- 182

Human   239 TSLKRSVYIESRIGTSTSF-------DSGIAGLSSISQCTSSSQLDETSHRWAQPDTAPLP---V 293
            ..|:|...:..|...|..|       |..||..:|:.                     |:|   :
  Fly   183 ALLERQHEMNQRFAGSGRFAFRHKDSDPEIASQASVE---------------------PIPLLGL 226

Human   294 PANIRFSIWISFFEIYNELLYDLLEPPSQQRKRQTLRLCEDQNGNPYVKDLNWIHVQDAEEAWKL 358
            ..:..:|:::::.||||..:|||||....|:..|:..:.||.|.:.:|..:..:.|:..|:|.::
  Fly   227 DEDNMYSVFVTYIEIYNNSVYDLLEDSGIQKTLQSKIIREDANRHMFVHGVTEVEVKTVEDALEV 291

Human   359 LKVGRKNQSFASTHLNQNSSRSHSIFSIRILHL----QGEGDIVPK----ISELSLCDLAGSER- 414
            .::|:|.:....|.||..||||||:|:||::..    |||..:..:    :|:|||.|||||||
  Fly   292 FQMGQKRKRMGHTVLNAESSRSHSVFNIRLVQAPTDSQGENVVQDRQNITVSQLSLVDLAGSERS 356

Human   415 CKDQKSGERLKEAGNINTSLHTLGRCIAALRQNQ---QNRSKQNLVPFRDSKLTRVFQGFFTGRG 476
            .:.:.:|.||:||||||.||.||..|:..||:||   .|......||:||||:|.:|:.:|.|.|
  Fly   357 SRTKNTGVRLREAGNINNSLMTLRTCLEYLRENQLAASNGLAPKKVPYRDSKITHMFKNYFDGEG 421

Human   477 RSCMIVNVNPCASTYDETLHVAKFSAIAS--QLVHAPPMQLGFPSLHSFIKEHSLQVSPSLEKGA 539
            :..|||.:||....|||.:.|.||:.:..  |:..|.||            :..|.::|...|..
  Fly   422 QVSMIVCINPRIEDYDENMQVMKFAEMTQEVQIARATPM------------KQDLGLTPGRRKAN 474

Human   540 KA---------DTGLDDDIENEADI-------------SMYGKEELLQVVEAMKTLLLK-ERQEK 581
            |.         :.|:.:..:.|.|:             .|...|..:::.|.|..|..: |:::|
  Fly   475 KLFKIAVNNLNELGIPEAKDLEVDVGLVYSLGPDFPAYEMDSPEAQIKIRELMHYLEQRIEKRKK 539

Human   582 LQLEMHLRDEICNEMVEQMQQREQWCSEHLDTQKEL--LEEMY----------EEKLNILKESLT 634
            |:..:.::.:...:|:..:.:      ::|..:.||  |:.:|          |:|:.| .||..
  Fly   540 LRANLDIKCDSFRQMLMNLDR------DNLQLRTELASLKAVYKQERDRSAALEKKVRI-HESSI 597

Human   635 SFYQEEIQERDEKIEELEALLQEARQQSVAHQQSGSELALRRSQRLAASASTQ------QLQEVK 693
            ......:.:::.:||||...|.|........:....:...:.|.:||..:...      :|:|.:
  Fly   598 DVLNNTLSKQERQIEELTFKLNEKENMLTQKEHEKEKQKKKFSSKLAVESDKNKREFELKLREQR 662

Human   694 AKLQQCKAELNSTTEELHKYQKML--EPPPSAKPFTIDVDKKLEEGQKNIRLLRTELQKLGESLQ 756
            .|||:   .:....|:|.....:|  |..||. |.:...:..|.|..:.....|||     ||..
  Fly   663 VKLQE---RMRIKDEKLRLVSNILQSEDLPSL-PRSQSSENILNEKDRGAYTARTE-----ESSV 718

Human   757 SAERACCHST---GA----GKLRQALTTCDDILIKQDQ------TLAE--LQNNMVLVKL-DLRK 805
            .|.|...::|   ||    .:.|::.:..|..|..:..      |:.:  |:|...:.|| ||::
  Fly   719 PATRTDIYATPRHGAAAANNRHRRSRSAGDKWLEHRAANPVPLGTIMQPYLKNRKSVTKLTDLKE 783

Human   806 KAACIAEQYHTVLK---LQGQVSAKKRLGT-------------NQ----ENQQPNQQPPGKKPFL 850
            ..|....:|..|.:   ..|.|..|...|.             |.    :.:.|...|..|:|..
  Fly   784 LTAHGTTKYCLVSQDADTDGDVETKLYKGNVIPTCGGGAQVVFNDVECLKQKSPVHSPTRKRPSN 848

Human   851 RNL-------LPRTPT 859
            .|:       :|.|.|
  Fly   849 GNISALGGGAVPSTVT 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF20A	NP_005724.1	KISc_KIF23_like	63..505	CDD:276819	149/465 (32%)
		SMC_N	<547..>795	CDD:330553	59/296 (20%)
		Globular. /evidence=ECO:0000255	763..890		29/140 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	832..865		9/52 (17%)
pav	NP_477025.1	KISc_KIF23_like	35..450	CDD:276819	149/465 (32%)
		Kinesin	42..452	CDD:278646	147/460 (32%)
		MKLP1_Arf_bdg	735..837	CDD:293148	18/101 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0247
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D314538at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R641
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850