Protein Alignment KIF20A and pav

DIOPT Version :10

• Sequence 1: NP_005724.1
• Gene: KIF20A / 10112
• HGNCID: 9787
• Length: 890
• Species: Homo sapiens
• Sequence 2: NP_477025.1
• Gene: pav / 38515
• FlyBaseID: FBgn0011692
• Length: 887
• Species: Drosophila melanogaster
• Alignment Length: 926
• Identity: 241/926 - (26%)
• Similarity: 407/926 - (43%)
• Gaps: 191/926 - (20%)

Human    46 VSTSLEDKQQVPSEDSMEKVKVYLRVRPLLPSELERQEDQGCVRIENVETLVLQAPKDSFALKSN 110
            |..::|.:::..|:.:.:.|.|:.||||     |:...|...:|::|..|:.|. |:|.......
  Fly    18 VHQTVEKQRRDTSDKARDPVNVFCRVRP-----LQSDADLTSLRVKNSTTIALN-PQDQLLQHHK 76

Human   111 ERGIGQATHRFTFSQIFGPEVGQASFFNLTVKEMVKDVLKGQNWLIYTYGVTNSGKTHTIQGTIK 175
            .....|...::.|..:|.|:..|...:....:.:|:::|||:|.|::|||||.||||:|:.|.::
  Fly    77 PHNGAQREVQYIFKHVFQPDATQQDVYAAVAQPLVENLLKGRNSLLFTYGVTGSGKTYTMTGNLR 141

Human   176 DGGILPRSLALIFNSLQGQLHPTPDLKPLLSNEVIWLDSKQIRQEEMKKLSLLNGG--LQEEELS 238
            ..||:||.|.::|.::                      |....::.:.|...|||.  |.||:
  Fly   142 HRGIMPRCLDVLFRTI----------------------SDYQAKKFVFKPDKLNGFEILSEED-- 182

Human   239 TSLKRSVYIESRIGTSTSF-------DSGIAGLSSISQCTSSSQLDETSHRWAQPDTAPLP---V 293
            ..|:|...:..|...|..|       |..||..:|:.                     |:|   :
  Fly   183 ALLERQHEMNQRFAGSGRFAFRHKDSDPEIASQASVE---------------------PIPLLGL 226

Human   294 PANIRFSIWISFFEIYNELLYDLLEPPSQQRKRQTLRLCEDQNGNPYVKDLNWIHVQDAEEAWKL 358
            ..:..:|:::::.||||..:|||||....|:..|:..:.||.|.:.:|..:..:.|:..|:|.::
  Fly   227 DEDNMYSVFVTYIEIYNNSVYDLLEDSGIQKTLQSKIIREDANRHMFVHGVTEVEVKTVEDALEV 291

Human   359 LKVGRKNQSFASTHLNQNSSRSHSIFSIRILHL----QGEGDIVPK----ISELSLCDLAGSER- 414
            .::|:|.:....|.||..||||||:|:||::..    |||..:..:    :|:|||.|||||||
  Fly   292 FQMGQKRKRMGHTVLNAESSRSHSVFNIRLVQAPTDSQGENVVQDRQNITVSQLSLVDLAGSERS 356

Human   415 CKDQKSGERLKEAGNINTSLHTLGRCIAALRQNQ---QNRSKQNLVPFRDSKLTRVFQGFFTGRG 476
            .:.:.:|.||:||||||.||.||..|:..||:||   .|......||:||||:|.:|:.:|.|.|
  Fly   357 SRTKNTGVRLREAGNINNSLMTLRTCLEYLRENQLAASNGLAPKKVPYRDSKITHMFKNYFDGEG 421

Human   477 RSCMIVNVNPCASTYDETLHVAKFSAIAS--QLVHAPPMQLGFPSLHSFIKEHSLQVSPSLEKGA 539
            :..|||.:||....|||.:.|.||:.:..  |:..|.||            :..|.::|...|..
  Fly   422 QVSMIVCINPRIEDYDENMQVMKFAEMTQEVQIARATPM------------KQDLGLTPGRRKAN 474

Human   540 KA---------DTGLDDDIENEADI-------------SMYGKEELLQVVEAMKTLLLK-ERQEK 581
            |.         :.|:.:..:.|.|:             .|...|..:::.|.|..|..: |:::|
  Fly   475 KLFKIAVNNLNELGIPEAKDLEVDVGLVYSLGPDFPAYEMDSPEAQIKIRELMHYLEQRIEKRKK 539

Human   582 LQLEMHLRDEICNEMVEQMQQREQWCSEHLDTQKEL--LEEMY----------EEKLNILKESLT 634
            |:..:.::.:...:|:..:.:      ::|..:.||  |:.:|          |:|:.| .||..
  Fly   540 LRANLDIKCDSFRQMLMNLDR------DNLQLRTELASLKAVYKQERDRSAALEKKVRI-HESSI 597

Human   635 SFYQEEIQERDEKIEELEALLQEARQQSVAHQQSGSELALRRSQRLAASASTQ------QLQEVK 693
            ......:.:::.:||||...|.|........:....:...:.|.:||..:...      :|:|.:
  Fly   598 DVLNNTLSKQERQIEELTFKLNEKENMLTQKEHEKEKQKKKFSSKLAVESDKNKREFELKLREQR 662

Human   694 AKLQQCKAELNSTTEELHKYQKML--EPPPSAKPFTIDVDKKLEEGQKNIRLLRTELQKLGESLQ 756
            .|||:   .:....|:|.....:|  |..||. |.:...:..|.|..:.....|||     ||..
  Fly   663 VKLQE---RMRIKDEKLRLVSNILQSEDLPSL-PRSQSSENILNEKDRGAYTARTE-----ESSV 718

Human   757 SAERACCHST---GA----GKLRQALTTCDDILIKQDQ------TLAE--LQNNMVLVKL-DLRK 805
            .|.|...::|   ||    .:.|::.:..|..|..:..      |:.:  |:|...:.|| ||::
  Fly   719 PATRTDIYATPRHGAAAANNRHRRSRSAGDKWLEHRAANPVPLGTIMQPYLKNRKSVTKLTDLKE 783

Human   806 KAACIAEQYHTVLK---LQGQVSAKKRLGT-------------NQ----ENQQPNQQPPGKKPFL 850
            ..|....:|..|.:   ..|.|..|...|.             |.    :.:.|...|..|:|..
  Fly   784 LTAHGTTKYCLVSQDADTDGDVETKLYKGNVIPTCGGGAQVVFNDVECLKQKSPVHSPTRKRPSN 848

Human   851 RNL-------LPRTPT 859
            .|:       :|.|.|
  Fly   849 GNISALGGGAVPSTVT 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF20A	NP_005724.1	KISc_KIF23_like	63..505	CDD:276819	149/465 (32%)
		SMC_prok_B	<547..>795	CDD:274008	59/296 (20%)
		RBD_KIF20A	602..657	CDD:409645	15/66 (23%)
		Globular. /evidence=ECO:0000255	763..890		29/140 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	832..865		9/52 (17%)
pav	NP_477025.1	KISc_KIF23_like	35..450	CDD:276819	149/465 (32%)
		PRK03918	<522..>687	CDD:235175	34/174 (20%)
		MKLP1_Arf_bdg	734..840	CDD:465166	19/105 (18%)