DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment OPN1MW3 and Rh3

DIOPT Version :9

Sequence 1:	NP_001316996.1	Gene:	OPN1MW3 / 101060233	HGNCID:	51831	Length:	364	Species:	Homo sapiens
Sequence 2:	NP_524411.1	Gene:	Rh3 / 42398	FlyBaseID:	FBgn0003249	Length:	383	Species:	Drosophila melanogaster

Alignment Length:	352	Identity:	83/352 - (23%)
Similarity:	141/352 - (40%)	Gaps:	51/352 - (14%)

- Green bases have known domain annotations that are detailed below.

Human    45 YHIAPRWVYHLTSVWM-----------------IFVVIASVFTNGLVLAATMKFKKLRHPLNWIL 92
            :::.|..:.|:...|:                 ||..:.|:..||||:......|.||.|.|.::
  Fly    33 WNVPPEELRHIPEHWLTYPEPPESMNYLLGTLYIFFTLMSMLGNGLVIWVFSAAKSLRTPSNILV 97

Human    93 VNLAVADLAETVIASTISVVNQVYGYFVLGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCK 157
            :|||..|.. .::.:.|.:.|..:..:.|||..|.:.|...|..||....:.|.|:::|:.|:.:
  Fly    98 INLAFCDFM-MMVKTPIFIYNSFHQGYALGHLGCQIFGIIGSYTGIAAGATNAFIAYDRFNVITR 161

Human   158 PFGNVRFDAKLAIVGIAFSWIWAAVW-TAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMI 221
            |........| ||..|.|.:::|..| .|.....|.|:.|.|..|||..|..:       .::..
  Fly   162 PMEGKMTHGK-AIAMIIFIYMYATPWVVACYTETWGRFVPEGYLTSCTFDYLT-------DNFDT 218

Human   222 VLMVTCC-----ITPLSIIVLCYLQV-------WLAIRAVAKQQK-ES------ESTQKAEKEVT 267
            .|.|.|.     :.|.::|...|.|:       ..|:|..||:.. ||      ::.:.||..:.
  Fly   219 RLFVACIFFFSFVCPTTMITYYYSQIVGHVFSHEKALRDQAKKMNVESLRSNVDKNKETAEIRIA 283

Human   268 RMVVVMVLAFCFCWGPYAFFACFAAANPGYPFHPLMAALPAFFAKSATIYNPVIYVFMNRQFR-- 330
            :..:.:...|...|.||...:...|........|....:||...|.....:|.:|...:.::|
  Fly   284 KAAITICFLFFCSWTPYGVMSLIGAFGDKTLLTPGATMIPACACKMVACIDPFVYAISHPRYRME 348

Human   331 ---NCILQLFGKKVDDGSELSSASKTE 354
               .|......:|..:.|.::|.|.|:
  Fly   349 LQKRCPWLALNEKAPESSAVASTSTTQ 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OPN1MW3	NP_001316996.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Required for 11-cis-retinal regeneration. /evidence=ECO:0000250\|UniProtKB:P04001	17..43
		7tm_4	61..>178	CDD:304433	36/116 (31%)
		7tm_1	71..322	CDD:278431	69/270 (26%)
Rh3	NP_524411.1	7tm_4	66..>191	CDD:304433	39/126 (31%)
Rh3	NP_524411.1	7tm_1	75..338	CDD:278431	69/271 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X120
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910