DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment OPN1MW3 and Rh2

DIOPT Version :9

Sequence 1:	NP_001316996.1	Gene:	OPN1MW3 / 101060233	HGNCID:	51831	Length:	364	Species:	Homo sapiens
Sequence 2:	NP_524398.1	Gene:	Rh2 / 42261	FlyBaseID:	FBgn0003248	Length:	381	Species:	Drosophila melanogaster

Alignment Length:	376	Identity:	101/376 - (26%)
Similarity:	160/376 - (42%)	Gaps:	67/376 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    39 PFE----GPNY------------HIAPRWVYHLTSVWMIF-----------------VVIASVFT 70
            ||:    ||.:            ::.|...:.:...|..|                 ::|.|...
  Fly    10 PFDLAHSGPRFQAQSSGNGSVLDNVLPDMAHLVNPYWSRFAPMDPMMSKILGLFTLAIMIISCCG 74

Human    71 NGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISVVNQVYGYFVLGHPMCVLEGYTVSL 135
            ||:|:......|.||.|.|.:::|||.:|.......|.:.::|..|..:|||...|.:.....||
  Fly    75 NGVVVYIFGGTKSLRTPANLLVLNLAFSDFCMMASQSPVMIINFYYETWVLGPLWCDIYAGCGSL 139

Human   136 CGITGLWSLAIISWERWMVVCKPFGNVRFDAKLAIVGIAFSWIWAAVWTAPPIFGWSRYWPHGLK 200
            .|...:||:.:|:::|:.|:.|.........|.:|:.|.|.|:.|..||..|:.|||.|.|.|..
  Fly   140 FGCVSIWSMCMIAFDRYNVIVKGINGTPMTIKTSIMKILFIWMMAVFWTVMPLIGWSAYVPEGNL 204

Human   201 TSCGPDVFSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAIRAVAKQQK----------- 254
            |:|..|..:....|  :||:|...:....|||.:|  || ..|..|.|||..:|
  Fly   205 TACSIDYMTRMWNP--RSYLITYSLFVYYTPLFLI--CY-SYWFIIAAVAAHEKAMREQAKKMNV 264

Human   255 ----ESESTQK-AEKEVTRMVVVMVLAFCFCWGPY---AFFACFAAANPGYPFHPLMAALPAFFA 311
                .||...| ||.::.::.:..:..:...|.||   .:|..|....    ..||.....|.||
  Fly   265 KSLRSSEDCDKSAEGKLAKVALTTISLWFMAWTPYLVICYFGLFKIDG----LTPLTTIWGATFA 325

Human   312 KSATIYNPVIYVFMNRQFR-----NCILQLFGKKVDDGSELSSASKTEVSS 357
            |::.:|||::|...:.::|     .|.:.:|| ..|:....:.||.||.:|
  Fly   326 KTSAVYNPIVYGISHPKYRIVLKEKCPMCVFG-NTDEPKPDAPASDTETTS 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OPN1MW3	NP_001316996.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Required for 11-cis-retinal regeneration. /evidence=ECO:0000250\|UniProtKB:P04001	17..43		2/7 (29%)
		7tm_4	61..>178	CDD:304433	35/133 (26%)
		7tm_1	71..322	CDD:278431	81/269 (30%)
Rh2	NP_524398.1	7tm_4	67..>237	CDD:304433	55/171 (32%)
Rh2	NP_524398.1	7tm_1	74..336	CDD:278431	81/270 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X120
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910