DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment OPN1MW3 and frpr-12

DIOPT Version :9

Sequence 1:	NP_001316996.1	Gene:	OPN1MW3 / 101060233	HGNCID:	51831	Length:	364	Species:	Homo sapiens
Sequence 2:	NP_001343680.1	Gene:	frpr-12 / 259953	WormBaseID:	WBGene00019445	Length:	388	Species:	Caenorhabditis elegans

Alignment Length:	417	Identity:	79/417 - (18%)
Similarity:	154/417 - (36%)	Gaps:	112/417 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    25 SSIFTYTNSNSTRGPF-------------------EGPNYHIAPRWVYHLTSVWMIFVVIASVFT 70
            ||:....||.||..|.                   :.|..::....:..:.|:.|:.:::..:..
Worm     4 SSVSNSRNSISTTPPIIDYYGRTRFELEYMLPNSTDFPTSNVQSYTLNEVFSMVMLPIILIGLLG 68

Human    71 NGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIA-STISVVNQVY--GYFVLGHPMCVLEGYT 132
            |.:.:....:....::.:.::|::|:..||...|.| .|.......:  ||..:|....:...:.
Worm    69 NTVSIYVYSRNHMKKNTIGFLLLSLSTIDLIVLVTALPTFGTYKFPFFPGYNKIGSAHTIFSAFC 133

Human   133 V-------SLCGITGLWSLAIISWERWMVVCKPF---------GNVRFDAKLAIVGIAFSWIWAA 181
            :       .:..:.|.:.:.:|:.|||..||:|.         ..:|  |.|.|:.|:.|
Worm   134 LVYIYPFGCMAKMIGQYIIVLIAVERWFAVCRPLQVQVWCTQKNTIR--AMLYIIAISIS----- 191

Human   182 VWTAPPIFGWSRYWPHGLKTSCGPDVFSGSS-----------YPGVQSYMIVLMVTCCITPLSII 235
             :.||      |:.......|.|. |..|.|           |.|::|.....::     |.:||
Worm   192 -FNAP------RFLEFTADLSTGV-VNMGLSHSANNTWYFYLYYGIRSIFFDALI-----PFAII 243

Human   236 VLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMVLAFCFCW-------------GPYAFF 287
            .:..:||...:....:::|...:.|:.||..|.|::|||:.:..|.             ..||.|
Worm   244 SVTNIQVIQQLHKSNEERKLLTTQQQKEKRTTTMLLVMVILYATCHFFNTTLKFINMVSKTYAQF 308

Human   288 ACFAAANPGYP----FHPLMAALPAFFAKSATIYNPVIYVFMNRQFR----NCI----------L 334
            .        :|    .|.:...|...::.| |::   ||:..:.::|    .|:          :
Worm   309 R--------FPVIRVIHHISNLLLVIYSAS-TVF---IYLIFSTKYRKVLSTCVTCGSTEELNTV 361

Human   335 QLFGKKVDDGSELSSASKTEVSSVSSV 361
            ...||:.....::.|.|....:|:.|:
Worm   362 SSRGKQKTTAFQIKSTSHNGYTSIKSI 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OPN1MW3	NP_001316996.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Required for 11-cis-retinal regeneration. /evidence=ECO:0000250\|UniProtKB:P04001	17..43		7/36 (19%)
		7tm_4	61..>178	CDD:304433	25/135 (19%)
		7tm_1	71..322	CDD:278431	59/297 (20%)
frpr-12	NP_001343680.1	7tmA_FMRFamide_R-like	53..346	CDD:320109	64/324 (20%)
		TM helix 1	54..78	CDD:320109	3/23 (13%)
		TM helix 2	87..109	CDD:320109	7/21 (33%)
		TM helix 3	135..157	CDD:320109	2/21 (10%)
		TM helix 4	180..196	CDD:320109	8/29 (28%)
		TM helix 5	225..248	CDD:320109	6/27 (22%)
		TM helix 6	272..297	CDD:320109	7/24 (29%)
		TM helix 7	314..339	CDD:320109	6/28 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910