DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment OPN1MW3 and frpr-4

DIOPT Version :9

Sequence 1:	NP_001316996.1	Gene:	OPN1MW3 / 101060233	HGNCID:	51831	Length:	364	Species:	Homo sapiens
Sequence 2:	NP_001309544.1	Gene:	frpr-4 / 183763	WormBaseID:	WBGene00016909	Length:	362	Species:	Caenorhabditis elegans

Alignment Length:	315	Identity:	59/315 - (18%)
Similarity:	123/315 - (39%)	Gaps:	67/315 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    44 NYHIAPRWVYHLTSVWMIFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIA-- 106
            ::|....:||..|       ::..:..|.|.|.|..: |..:..:.::|.:|:|:|:...|.|
Worm     6 DFHRIMAFVYLPT-------ILIGLLGNLLSLYAYSR-KNRKSMVGFLLYSLSVSDIFLLVFALP 62

Human   107 ---------------STISVVNQVYGYFVLGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVC 156
                           |.:......|.|     |:|::    ...|   .|:.:.:|:.|||:.||
Worm    63 LFSIMYLPIWTDEQRSFVVAYTAKYVY-----PLCMM----AKTC---SLYIMVLITIERWIAVC 115

Human   157 KPFGNVRFDAKLAIVGIAFSWIWAAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQS--- 218
            :|     .:.::.......|:..||:.|...:..::|::...::...|...|........:.
Worm   116 RP-----LEVQIWCRYTTSSYSIAAIITFAVVLNFARFFEFEIEYIDGLAFFRRDLLDSEKHWWY 175

Human   219 ----YMIVLMVTCCITPLSIIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMVLAFCF 279
                ::|:.::...:.|..|:.:..:.:...:|...|::......|:.|:..|.|::|:.:.|.|
Worm   176 FMFYFIIISIIFDYLVPFVIMFVANMLIISELRRTKKERSLMTIQQQKEQNTTVMLLVITIFFGF 240

Human   280 CWGPYAFFACFAAANPGYPFHPLMAALPAFFAKSATIYNPVIYVFMNRQFRNCIL 334
            |                :.|...:....:|..|..||.|  ||:.|..:..|.::
Worm   241 C----------------HFFSMALKLAESFVGKFLTIQN--IYLEMLGEIFNYLI 277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OPN1MW3	NP_001316996.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Required for 11-cis-retinal regeneration. /evidence=ECO:0000250\|UniProtKB:P04001	17..43
		7tm_4	61..>178	CDD:304433	26/133 (20%)
		7tm_1	71..322	CDD:278431	51/274 (19%)
frpr-4	NP_001309544.1	7tmA_FMRFamide_R-like	33..299	CDD:320109	51/281 (18%)
		TM helix 2	43..65	CDD:320109	6/21 (29%)
		TM helix 3	86..108	CDD:320109	7/33 (21%)
		TM helix 4	131..147	CDD:320109	3/15 (20%)
		TM helix 5	178..201	CDD:320109	3/22 (14%)
		TM helix 6	225..250	CDD:320109	7/40 (18%)
		TM helix 7	265..292	CDD:320109	3/13 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910