DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment OPN1MW3 and dmsr-8

DIOPT Version :9

Sequence 1:	NP_001316996.1	Gene:	OPN1MW3 / 101060233	HGNCID:	51831	Length:	364	Species:	Homo sapiens
Sequence 2:	NP_505697.3	Gene:	dmsr-8 / 183225	WormBaseID:	WBGene00007951	Length:	487	Species:	Caenorhabditis elegans

Alignment Length:	322	Identity:	64/322 - (19%)
Similarity:	103/322 - (31%)	Gaps:	119/322 - (36%)

- Green bases have known domain annotations that are detailed below.

Human    45 YHIAPRWVYHLTSVWMIFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTI 109
            ||.....::|.||:|:            .||.|.::...:|.               .|.:|..
Worm   110 YHSQATVIFHATSIWL------------TVLLAQIRVFSIRR---------------ATSVAGE- 146

Human   110 SVVNQVYGYFVLGHPMCVLEGYT---VSLCGITGLWSLAIIS-----WERWMVVCKPFGNVRFDA 166
            ||.||:         .|::...|   |.|..:..:.:..||.     |    :.||.......|.
Worm   147 SVTNQM---------TCIIAVTTFIVVCLLNVPNMLTFEIIETPASLW----LQCKANETAEDDM 198

Human   167 KLAIV---------GIAFSWIWAAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIV 222
            .:.:|         .|||                   |.:|                     ::.
Worm   199 LVYLVAPSDHCGLLNIAF-------------------WTNG---------------------VLF 223

Human   223 LMVTCCITPLSIIVLCYLQVWLAIRAVAKQQKESESTQKAEK----EVTRMVVVMVLAFCFCWGP 283
            .:|.|.:...||:.|..:     ||.|.|::|:.......::    ..|.|:|.::..|.|...|
Worm   224 KVVPCLLLTFSIVALVSI-----IRDVGKRRKQLAQVMNKKRMPRDHTTPMLVAVLSIFLFAELP 283

Human   284 YAFFACFAAANPGYPFH--------PLMAALPAFFAKSATIYNPVIYVFMNRQFRNCILQLF 337
            ......|.|......|:        .:|..|.  ...||.  |.:||..|:|:||...:|:|
Worm   284 QGVLHVFNAIFTKETFYDKIYIHLGDVMDVLS--LLNSAV--NFIIYCAMSRKFRAVFIQIF 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OPN1MW3	NP_001316996.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Required for 11-cis-retinal regeneration. /evidence=ECO:0000250\|UniProtKB:P04001	17..43
		7tm_4	61..>178	CDD:304433	24/133 (18%)
		7tm_1	71..322	CDD:278431	50/279 (18%)
dmsr-8	NP_505697.3	7tmA_FMRFamide_R-like	30..337	CDD:320109	62/316 (20%)
		TM helix 1	31..55	CDD:320109
		TM helix 2	63..85	CDD:320109
		TM helix 3	109..131	CDD:320109	8/32 (25%)
		TM helix 4	155..171	CDD:320109	3/15 (20%)
		TM helix 5	213..236	CDD:320109	8/62 (13%)
		TM helix 6	264..289	CDD:320109	6/24 (25%)
		TM helix 7	305..330	CDD:320109	7/28 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910