DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment OPN1MW3 and daf-37

DIOPT Version :9

Sequence 1:	NP_001316996.1	Gene:	OPN1MW3 / 101060233	HGNCID:	51831	Length:	364	Species:	Homo sapiens
Sequence 2:	NP_001309490.1	Gene:	daf-37 / 183041	WormBaseID:	WBGene00016246	Length:	482	Species:	Caenorhabditis elegans

Alignment Length:	357	Identity:	69/357 - (19%)
Similarity:	126/357 - (35%)	Gaps:	97/357 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    53 YHLTSVWMIFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISVVNQVYG 117
            :.|.||....:.:..:|.|. ..|..:....:|:|.|..|..|||.|....:.|..|..:..:..
Worm    33 FFLISVVGTLIGLFGLFGNA-TTALILTRPSMRNPNNLFLTALAVFDSCLLITAFFIYAMEYIIE 96

Human   118 Y-----------------FVLGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNVRFD 165
            |                 |.|.|         :|..|  .::....::.||::.||.|    :..
Worm    97 YTAAFDLYVAWLTYLRFAFALSH---------ISQTG--SVYITVAVTIERYLAVCHP----KSS 146

Human   166 AKLAIVGIAFSWIWAAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIV-------- 222
            ..:...|.| :|....|.|...:|..::::.  |:.:..|....||::   |||:::
Worm   147 KNMCGPGGA-AWTILGVTTFAVVFNCTKFFE--LQVTVNPSCPDGSNW---QSYILLPSAMASNP 205

Human   223 ---LMVTCCITPLSIIVLCYLQVWL--AI-------------------------------RAVAK 251
               .:.:..:|...::...:|.:.|  ||                               |.:|.
Worm   206 IYQQVYSLWVTNFVMVFFPFLTLLLFNAIIAYTIRQSLEKYDFHNQKSVVAALSASVNLPRNIAG 270

Human   252 QQKESESTQKAEKEVTRMVVVMVLAFCFC--WGPYAFFACFAAANPG--------YPFHPLMAAL 306
            ....:|..:|: :|.|.::|::|..|..|  ||   |.........|        :.|:......
Worm   271 ISSRNELKEKS-REATLVLVIIVFIFLGCNFWG---FVLTLLERIMGQETLMVEHHIFYTFSREA 331

Human   307 PAFFAKSATIYNPVIYVFMNRQFRNCILQLFG 338
            ..|.|...:..|.|||:...:.||..::.::|
Worm   332 INFLAIINSSINFVIYLLFGKDFRKELVVVYG 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OPN1MW3	NP_001316996.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Required for 11-cis-retinal regeneration. /evidence=ECO:0000250\|UniProtKB:P04001	17..43
		7tm_4	61..>178	CDD:304433	26/133 (20%)
		7tm_1	71..322	CDD:278431	60/321 (19%)
daf-37	NP_001309490.1	7tm_4	34..>213	CDD:304433	40/200 (20%)
daf-37	NP_001309490.1	7tm_1	55..347	CDD:278431	59/316 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910