DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment OPN1MW3 and frpr-17

DIOPT Version :9

Sequence 1:	NP_001316996.1	Gene:	OPN1MW3 / 101060233	HGNCID:	51831	Length:	364	Species:	Homo sapiens
Sequence 2:	NP_510400.2	Gene:	frpr-17 / 181541	WormBaseID:	WBGene00011765	Length:	403	Species:	Caenorhabditis elegans

Alignment Length:	365	Identity:	71/365 - (19%)
Similarity:	127/365 - (34%)	Gaps:	83/365 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    39 PFEGPNYHIAPRWVYHLTSVWMIFVVIASVFTNGLVLAATMKF----KKLRHPLNWILVNLAVAD 99
            |..|..||.:..|.|...::.:|.:::..|...|:|..|...|    .::|...|..|.:||.:|
Worm    52 PLCGICYHGSKEWDYIRFNIIVIGIILPIVGVFGIVGNAISAFVYSRPEMRCSTNLYLFSLACSD 116

Human   100 LA-----------ETVIASTISVVNQVYGYFVLGHPMCVLEGYTVSLCGITGLWSLAIISWERWM 153
            ..           ||....:::|.........:.:||    |.....|.:   :.......:.::
Worm   117 TGVVLTGIFLFSLETFRPFSLTVARISGQLSAIVYPM----GMIAQTCSV---YFTVCAGVDCFV 174

Human   154 VVCKPFGNVR--FDAK-----LAIVGIAFSWIWAAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGS 211
            .||.| ..||  |..|     ||...:.||    .::..|..|       .|....|......|.
Worm   175 QVCLP-EKVRRAFSRKETVHFLATCVVIFS----VLYNVPHFF-------EGFVIDCYHQELGGM 227

Human   212 S-------------YPGVQSYMIVLMVTCCITPL-SIIVLCYLQVWLAIRAVAKQQKESESTQKA 262
            |             |..:. |..:..:...:.|| ::|:|..|.:..::          ..:..:
Worm   228 SKEVCPATLRYNEMYQSIY-YKYMYAIFLAVGPLFTLIILNTLIIGFSV----------FGSSAS 281

Human   263 EKEVTRMVVVMVLAFCFCWGPYA----FFACFAAANPGYPFHPLMAALPAFFAKSATIYNPVIYV 323
            ..:.|..::::||.| .|....|    .|..:.:...|...: .:..|..|.....:.:|.:||:
Worm   282 NMDDTMSLILVVLLF-ICCNTIALVINIFESYLSETLGSKIN-YIVDLSNFLVVFNSSFNIIIYI 344

Human   324 FMNRQFRNCILQLFGKKV----DDG-------SELSSASK 352
            ..:|.|.:.:...|..:.    :||       :|..|.||
Worm   345 KYSRPFADTLFSYFCNRKPITDNDGPGPPMLITEKPSRSK 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OPN1MW3	NP_001316996.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Required for 11-cis-retinal regeneration. /evidence=ECO:0000250\|UniProtKB:P04001	17..43		1/3 (33%)
		7tm_4	61..>178	CDD:304433	30/138 (22%)
		7tm_1	71..322	CDD:278431	52/290 (18%)
frpr-17	NP_510400.2	7tmA_FMRFamide_R-like	81..354	CDD:320109	57/304 (19%)
		TM helix 2	106..128	CDD:320109	5/21 (24%)
		TM helix 3	148..170	CDD:320109	4/28 (14%)
		TM helix 4	194..210	CDD:320109	4/19 (21%)
		TM helix 5	245..268	CDD:320109	5/23 (22%)
		TM helix 6	283..308	CDD:320109	6/25 (24%)
		TM helix 7	322..347	CDD:320109	5/25 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910