DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment OPN1MW3 and fshr-1

DIOPT Version :9

Sequence 1:	NP_001316996.1	Gene:	OPN1MW3 / 101060233	HGNCID:	51831	Length:	364	Species:	Homo sapiens
Sequence 2:	NP_001263853.1	Gene:	fshr-1 / 179381	WormBaseID:	WBGene00008239	Length:	932	Species:	Caenorhabditis elegans

Alignment Length:	336	Identity:	78/336 - (23%)
Similarity:	136/336 - (40%)	Gaps:	58/336 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    12 GRHPQDSYEDSTQ---SSIFTYTNSNSTRGPFEG----PNYHIAPRWVYHLTSVWMIFVVIASVF 69
            |..|..|..:..|   |:|..|...::. .|.|.    |...||         ||:  |.:|::.
Worm   393 GAEPCQSIGEEVQKYYSNITCYPQPDAL-NPCENIVGYPFLRIA---------VWV--VCLAAIV 445

Human    70 TNGLV--LAATMKFKKLR-HPLNWILVNLAVADLAETVIASTISVVNQVYGYFVLGHPM------ 125
            .|.:|  |...:..|::| |.|  .::|::|||:...:..:.:::.:.........|.:
Worm   446 GNIIVWALLGIVYEKRMRMHYL--YMINMSVADMVTGIYLAVLAIADAKMSDEYYRHAVWWQTGW 508

Human   126 -CVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNVRFDAKLAIVGIAFSWIWAAVWTAPPIF 189
             |...|:........|:.|:.:|::|......:.|...|...|:.::.:...|::|.:....|.|
Worm   509 GCRAAGFLAVFASELGIISMFLIAFEMSYNTRQSFRGRRLSPKVGVLLMIGGWLFAIIMAILPWF 573

Human   190 GWSRYWPHGLKTSCGP----DVFSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAIRAVA 250
            ..|.|   ...:.|.|    .:|.       :||:|.        .||...|.:..:.|:...:.
Worm   574 DVSSY---SESSVCLPLRAATIFD-------KSYLIF--------GLSFNFLAFAAMALSYGFIV 620

Human   251 KQQKESESTQKAEKEVTRMVVVMVLAFCFCWGPYAFFACFAAANPGYPFHPLMAA--LPAFFAKS 313
            |..||:|:.::....:|:| .|:|:....||.|..||.  ..|..|:|...|.:|  :..||...
Worm   621 KMLKENETREEDRALITKM-TVLVVTDLICWFPTLFFG--FTATIGFPLLSLSSAKFVLVFFFPI 682

Human   314 ATIYNPVIYVF 324
            ....||.:|||
Worm   683 NAFANPFLYVF 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OPN1MW3	NP_001316996.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		3/10 (30%)
		Required for 11-cis-retinal regeneration. /evidence=ECO:0000250\|UniProtKB:P04001	17..43		7/32 (22%)
		7tm_4	61..>178	CDD:304433	23/126 (18%)
		7tm_1	71..322	CDD:278431	59/266 (22%)
fshr-1	NP_001263853.1	leucine-rich repeat	87..108	CDD:275380
		LRR	<97..>293	CDD:227223
		leucine-rich repeat	109..133	CDD:275380
		leucine-rich repeat	134..158	CDD:275380
		leucine-rich repeat	159..174	CDD:275380
		leucine-rich repeat	185..208	CDD:275380
		leucine-rich repeat	209..231	CDD:275380
		leucine-rich repeat	232..255	CDD:275380
		leucine-rich repeat	256..276	CDD:275380
		7tmA_Glyco_hormone_R	430..702	CDD:320264	69/298 (23%)
		TM helix 1	432..456	CDD:320264	9/34 (26%)
		TM helix 2	466..487	CDD:320264	5/22 (23%)
		TM helix 3	511..533	CDD:320264	4/21 (19%)
		TM helix 4	555..571	CDD:320264	2/15 (13%)
		TM helix 5	595..618	CDD:320264	7/30 (23%)
		TM helix 6	633..658	CDD:320264	9/27 (33%)
		TM helix 7	670..695	CDD:320264	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910