DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rnf167 and RNF167

DIOPT Version :9

Sequence 1:	XP_005165694.2	Gene:	rnf167 / 101055497	ZFINID:	ZDB-GENE-110126-2	Length:	401	Species:	Danio rerio
Sequence 2:	NP_001357232.1	Gene:	RNF167 / 26001	HGNCID:	24544	Length:	374	Species:	Homo sapiens

Alignment Length:	365	Identity:	182/365 - (49%)
Similarity:	236/365 - (64%)	Gaps:	41/365 - (11%)

- Green bases have known domain annotations that are detailed below.

Zfish     7 PLAVSVLLIIFCTLVPSPGQAYIYAHYSNMTSMLFEDLPALFGSALPKDGLMGVLIEARPQNACT 71
            ||.|.|..:::..   :|.:..|.|...:..||.|.|||||||:.|.::||.|.|:||.|.|||:
Human     7 PLPVVVAAVLWGA---APTRGLIRATSDHNASMDFADLPALFGATLSQEGLQGFLVEAHPDNACS 68

Zfish    72 PIDPPPASPTPADPNSTTKYIVLIRRYDCNFDVKVYHAQQAGYSAAIVHNMYSNSLLNMGYSNET 136
            ||.|||    ||..|.:. :|.|:||:|||||:||.:||:|||.||:|||:.||.||||.:::|.
Human    69 PIAPPP----PAPVNGSV-FIALLRRFDCNFDLKVLNAQKAGYGAAVVHNVNSNELLNMVWNSEE 128

Zfish   137 IAEEISIPSVFTSFFASQMLHKI-IPEKGAYVVLKPEFSFPLSYYLIPFTGVVCMIIIVMVIIMI 200
            |.::|.|||||....:|:.|..: :.||||.|:|.|:.:|||.||||||||:|.::::.|..:||
Human   129 IQQQIWIPSVFIGERSSEYLRALFVYEKGARVLLVPDNTFPLGYYLIPFTGIVGLLVLAMGAVMI 193

Zfish   201 VRCVQHRKRLRKNRLSKEQLKKIPIHKFNK------------------------GDSYDVCAICL 241
            .||:||||||::|||:|||||:||.|.:.|                        ||.||||||||
Human   194 ARCIQHRKRLQRNRLTKEQLKQIPTHDYQKALNSSMFCPDLILPTCLISSTGFVGDQYDVCAICL 258

Zfish   242 DEYEEGDKLRVLPCSHAYHSRCVDPWLTQTKKTCPVCKQRVTR-PNPEYSESSDSDEEAG----P 301
            ||||:|||||||||:|||||||||||||||:||||:|||.|.| |..|..|.....:|.|    |
Human   259 DEYEDGDKLRVLPCAHAYHSRCVDPWLTQTRKTCPICKQPVHRGPGDEDQEEETQGQEEGDEGEP 323

Zfish   302 HDAEEEDERTPLL--RPSNPGSPASSSPPPSYSSTVASEP 339
            .| ....||||||  .|:.|.|..|.:|.|......:::|
Human   324 RD-HPASERTPLLGSSPTLPTSFGSLAPAPLVFPGPSTDP 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rnf167	XP_005165694.2	PA_C_RZF_like	14..177	CDD:239038	77/163 (47%)
		RING-H2_RNF167	235..280	CDD:319711	40/44 (91%)
		RING-H2 finger (C3H2C3-type)	237..278	CDD:319711	37/40 (93%)
RNF167	NP_001357232.1	PA_C_RZF_like	20..170	CDD:239038	77/154 (50%)
		RING-H2_RNF167	252..297	CDD:319711	40/44 (91%)
		RING-H2 finger (C3H2C3-type)	254..295	CDD:319711	37/40 (93%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I24944
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41046
Inparanoid	1	1.050	345	1.000	Inparanoid score	I8782
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG51404
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	1	1.000	-	-		FOG0001489
OrthoInspector	1	1.000	-	-		oto45987
orthoMCL	1	0.900	-	-		OOG6_103040
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9031
SonicParanoid	1	1.000	-	-		X670
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	15	15.410