Protein Alignment NOTCH2NLB and slow

DIOPT Version :9

• Sequence 1: XP_011508558.1
• Gene: NOTCH2NLB / 100996763
• HGNCID: 53923
• Length: 412
• Species: Homo sapiens
• Sequence 2: NP_647898.3
• Gene: slow / 38540
• FlyBaseID: FBgn0035539
• Length: 512
• Species: Drosophila melanogaster
• Alignment Length: 379
• Identity: 90/379 - (23%)
• Similarity: 126/379 - (33%)
• Gaps: 101/379 - (26%)

Human    63 PRKFQPNFGRLRRRPRSG---GLRARG-VEAFAPGLRSVAPGPEPLKQEEGRREWGSSIGTPSPC 123
            |....|.:|:.....:..   |:|.|| ..:|.|.:......|..|.:........|||||..|.
  Fly   135 PMPLSPRYGKGEDNTQDVEFIGVRERGRGYSFVPSVTVTTAPPPNLNRRSASPGSRSSIGTIPPL 199

Human   124 GSAQAAAAEEATEKMPALRPALLWALLALWLCCATPAHALQCRDGYEPCVNEGMCVTYHNGTGYC 188
            ..|:...:...|...|                   |.:.:...:.:|         |...|.||
  Fly   200 VPARRGYSYTTTTSSP-------------------PVNTITTDNPFE---------TNTIGRGY- 235

Human   189 KCPEGFLGEYCQHRDPCEKNR---CQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSR 250
                        ..||.|..|   |....|........:...|.........||    .|.|..:
  Fly   236 ------------PTDPKEMERRHICMQQRTVTMPVKRTEVYSRPTWKHVATPCQ----PPTFSGQ 284

Human   251 PCLNGGTCH-MLSRD----------TYECTCQVGFTG--KECQWTDACL----SHPCANGSTCTT 298
            .|......| ...||          ||:| |    ||  :|...:|:|:    |..|.||..||.
  Fly   285 KCTRVQVVHEQAYRDVIDHKTAQQMTYDC-C----TGWSRENPRSDSCMKPICSARCQNGGNCTA 344

Human   299 VANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGICLNLPGSYQCQCLQGFTGQYCDSLYVPCA 363
            .:   :|.|.|||||:.||.||:||.....|...  |:|..|||.|:|.|||..|
  Fly   345 PS---TCSCPTGFTGRFCEQDVDECQTEKPCDQQ--CINTHGSYFCRCRQGFVLQ---------- 394

Human   364 PSPCVNGGTCRQ---TGDFTFECNCLPETV-----RRGTELWERDREVWNGKEH 409
                .:..:|::   ..|..||...|...:     ...|.|.:.::.:.|.:.|
  Fly   395 ----SDQQSCKKVSTNADDAFEARDLENDIDDTDAEVATRLQKIEKSLANERVH 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NOTCH2NLB	XP_011508558.1	EGF_CA	246..280	CDD:238011	12/46 (26%)
		EGF_CA	283..317	CDD:238011	15/37 (41%)
		EGF_CA	319..355	CDD:238011	16/35 (46%)
slow	NP_647898.3	EMI	246..318	CDD:284877	17/80 (21%)
		EGF_CA	<336..360	CDD:238011	12/26 (46%)
		EGF_CA	362..401	CDD:214542	16/54 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910