Protein Alignment NOTCH2NLB and dsl-4

DIOPT Version :9

• Sequence 1: XP_011508558.1
• Gene: NOTCH2NLB / 100996763
• HGNCID: 53923
• Length: 412
• Species: Homo sapiens
• Sequence 2: NP_001359594.1
• Gene: dsl-4 / 184563
• WormBaseID: WBGene00001106
• Length: 368
• Species: Caenorhabditis elegans
• Alignment Length: 214
• Identity: 70/214 - (32%)
• Similarity: 97/214 - (45%)
• Gaps: 36/214 - (16%)

Human   186 GYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSR 250
            || ||..|:.|..|...| |..| |.|.|:|   .:.||  |.|:.||.|..|:|     |..|.
 Worm   154 GY-KCAPGYSGPNCDKVD-CPFN-CHNHGSC---EVPGK--CMCSQGFFGTYCEY-----CKPST 205

Human   251 PCLNGGT------CHMLSRDTYECTCQVGFTGKECQWTDAC-LSHPCANGSTCT--TVANQFSCK 306
            .|.:|..      ||     .|.|.|..|:.|......|.| .:.||.:|:..:  ||:..|.|.
 Worm   206 TCKHGAVLVNELGCH-----PYTCRCFEGYAGDNGDKDDVCYYAKPCRHGNCVSNVTVSGGFECI 265

Human   307 CLTGFTGQKCETDVN--ECDIPGHCQHGGICLNLPGSYQCQCLQGFTGQYCD-SLYVPCAPSPCV 368
            |...|.|::||..:.  :|...|:||:.|:|..:.|..:|:|..||||::|: .....|....|.
 Worm   266 CPKAFGGRRCEKRIARWDCSDEGYCQNKGVCSFVDGISRCRCAVGFTGKHCERKTAKTCLKKKCR 330

Human   369 NGGTC----RQTGDFTFEC 383
            .|..|    ::||  |..|
 Worm   331 EGFICIIDNKKTG--TMPC 347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NOTCH2NLB	XP_011508558.1	EGF_CA	246..280	CDD:238011	11/39 (28%)
		EGF_CA	283..317	CDD:238011	12/36 (33%)
		EGF_CA	319..355	CDD:238011	13/37 (35%)
dsl-4	NP_001359594.1	DSL	110..166	CDD:366627	6/12 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	96	1.000	Inparanoid score	I4042
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.960