DRSC/TRiP Functional Genomics Resources

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Protein Alignment NOTCH2NLC and lin-12

DIOPT Version :10

Sequence 1:NP_001350942.1 Gene:NOTCH2NLC / 100996717 HGNCID:53924 Length:293 Species:Homo sapiens
Sequence 2:NP_499007.1 Gene:lin-12 / 176282 WormBaseID:WBGene00003001 Length:1429 Species:Caenorhabditis elegans


Alignment Length:360 Identity:100/360 - (27%)
Similarity:130/360 - (36%) Gaps:121/360 - (33%)


- Green bases have known domain annotations that are detailed below.


Human    21 EDARPAPLCCGRCWRSGCAARPPRMCRDGY-------------EPCVNEGMCVTYHNGTG---YC 69
            :|.|.....|..|..:|.:...| .|..||             ..|:|.|.|:    |.|   .|
 Worm    79 KDYRMETCVCKDCDINGNSLLKP-SCPSGYGGDDCKTQGWCYPSVCMNGGQCI----GAGNRAKC 138

Human    70 KCPEGFLGEYCQ-HRDPCE--KNRCQNGGTCVAQAMLGKATCRCASGFTGEDC------------ 119
            .||:||.||.|: ..:.||  ||.|.|..||:  ..||...|.|..||...||            
 Worm   139 ACPDGFKGERCELDVNECEENKNACGNRSTCM--NTLGTYICVCPQGFLPPDCLKPGNTSTVEFK 201

Human   120 ------QYSTSHPCFVSRPCLNGG------------------TCHMLSRDT-------------- 146
                  :.|..||...|..|.|||                  ||.:|.::.              
 Worm   202 QPVCFLEISADHPDGRSMYCQNGGFCDKASSKCQCPPGYHGSTCELLEKEDSCASNPCSHGVCIS 266

Human   147 ----YECTCQVGFTGKECQ-WTDACLSHPCANGSTCTTVANQ----------------------- 183
                ::|.|..|::|..|| ..|.|:::.|..||.|....|.                       
 Worm   267 FSGGFQCICDDGYSGSYCQEGKDNCVNNKCEAGSKCINGVNSYFCDCPPERTGPYCEKMDCSAIP 331

Human   184 -----------------FSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGF 231
                             |.|:|..|:.|..||.|.|||.....|.:.|||:|||||::|.|.:||
 Worm   332 DICNHGTCIDSPLSEKAFECQCEPGYEGILCEQDKNECLSENMCLNNGTCVNLPGSFRCDCARGF 396

Human   232 TGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNC 266
            .|::||.....|....|.|.|||..|.|.:..|.|
 Worm   397 GGKWCDEPLNMCQDFHCENDGTCMHTSDHSPVCQC 431

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NOTCH2NLCNP_001350942.1 EGF_CA 200..236 CDD:238011 18/35 (51%)
lin-12NP_499007.1 EGF_CA 152..189 CDD:238011 14/38 (37%)
EGF_2 220..245 CDD:400365 4/24 (17%)
EGF_CA 252..285 CDD:238011 4/32 (13%)
EGF_CA 293..323 CDD:238011 5/29 (17%)
EGF_CA 365..401 CDD:238011 18/35 (51%)
EGF_CA 505..541 CDD:238011
EGF_CA 545..579 CDD:238011
NL 635..668 CDD:197463
Notch 675..709 CDD:459658
Notch 715..750 CDD:459658
NOD 753..807 CDD:462014
NODP 842..898 CDD:462229
ANK repeat 1052..1091 CDD:293786
ANKYR 1070..1295 CDD:440430
ANK repeat 1093..1124 CDD:293786
ANK repeat 1126..1160 CDD:293786
ANK repeat 1162..1201 CDD:293786
ANK repeat 1203..1238 CDD:293786
ANK repeat 1240..1271 CDD:293786
Blue background indicates that the domain is not in the aligned region.

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