DRSC/TRiP Functional Genomics Resources

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Protein Alignment NOTCH2NLC and notch2

DIOPT Version :10

Sequence 1:NP_001350942.1 Gene:NOTCH2NLC / 100996717 HGNCID:53924 Length:293 Species:Homo sapiens
Sequence 2:XP_002939126.3 Gene:notch2 / 100486344 XenbaseID:XB-GENE-6046917 Length:2455 Species:Xenopus tropicalis


Alignment Length:241 Identity:127/241 - (52%)
Similarity:169/241 - (70%) Gaps:3/241 - (1%)


- Green bases have known domain annotations that are detailed below.


Human    28 LCCGRCWRSGCAARPPRMCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQ 92
            ||.......||..   ..||...|||:|||.|:|..:|:.||||.:.|:|:|||.::||::..|.
 Frog     9 LCVLLLGMPGCDG---LQCRGASEPCLNEGKCITNDDGSAYCKCTDAFVGKYCQLQNPCQETICL 70

Human    93 NGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTG 157
            |||||...:.|.|..|.||.||.||:|:...::.|.:::||:||||||:|:.:.|:|.|..|:.|
 Frog    71 NGGTCKVSSDLSKGVCTCAPGFGGENCKQPVANVCSLTQPCMNGGTCHLLTLELYDCICPFGWRG 135

Human   158 KECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGS 222
            .:|::.|||.|.||||||||....||::|.|..|:||.|||.|||||..||.|::||||.|.|||
 Frog   136 NDCKFIDACASQPCANGSTCIPNENQYTCSCQAGYTGLKCEVDVNECGPPGMCKNGGTCENFPGS 200

Human   223 YQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLP 268
            |:|||..|:|||.|:|.::||:||||:||||||||.:|.:||||||
 Frog   201 YRCQCHPGYTGQRCESPFIPCSPSPCMNGGTCRQTSEFAYECNCLP 246

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NOTCH2NLCNP_001350942.1 EGF_CA 200..236 CDD:238011 24/35 (69%)
notch2XP_002939126.3 EGF_CA 141..176 CDD:238011 20/34 (59%)
EGF_CA 178..215 CDD:238011 24/36 (67%)
EGF_CA 256..292 CDD:238011
EGF_CA 294..331 CDD:238011
EGF_CA 334..369 CDD:238011
EGF_CA 411..450 CDD:238011
EGF_CA 452..488 CDD:238011
EGF_CA 491..526 CDD:238011
EGF_CA 528..564 CDD:238011
EGF_CA 566..600 CDD:238011
EGF_CA 604..639 CDD:238011
EGF_CA 641..676 CDD:238011
EGF_CA 678..713 CDD:238011
EGF_CA 717..751 CDD:238011
EGF_CA 753..789 CDD:238011
EGF_CA 791..827 CDD:238011
EGF_CA 869..905 CDD:238011
EGF_CA 907..943 CDD:238011
EGF_CA 945..980 CDD:238011
EGF_CA 983..1018 CDD:238011
EGF_CA 1022..1057 CDD:238011
EGF_CA 1147..1181 CDD:238011
EGF_CA 1184..1219 CDD:238011
EGF_CA 1221..1261 CDD:238011
EGF_CA 1263..1301 CDD:238011
EGF_CA <1311..1342 CDD:238011
Notch 1426..1457 CDD:459658
Notch 1464..1498 CDD:459658
Notch 1504..1536 CDD:459658
NOD 1540..1595 CDD:462014
NODP 1620..1676 CDD:462229
JMTM_Notch2 1661..1742 CDD:411986
ANK repeat 1829..1876 CDD:293786
ANKYR <1858..2069 CDD:440430
ANK repeat 1879..1909 CDD:293786
ANK repeat 1911..1976 CDD:293786
ANK repeat 1978..2009 CDD:293786
ANK repeat 2011..2042 CDD:293786
Blue background indicates that the domain is not in the aligned region.

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