DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment POTEB and Act57B

DIOPT Version :9

Sequence 1:	NP_001264233.1	Gene:	POTEB / 100996331	HGNCID:	33734	Length:	544	Species:	Homo sapiens
Sequence 2:	NP_523800.1	Gene:	Act57B / 37368	FlyBaseID:	FBgn0000044	Length:	376	Species:	Drosophila melanogaster

Alignment Length:	255	Identity:	53/255 - (20%)
Similarity:	94/255 - (36%)	Gaps:	71/255 - (27%)

- Green bases have known domain annotations that are detailed below.

Human    37 GSGTSNVGTSGDHDDSFMKTLRSKMGKWCCHCFPCCRG--SGKSNVGTW-GDYDDS--AFMEPRY 96
            |||....|.:|  ||:......|.:|:      |..:|  .|.....:: ||...|  ..:..:|
  Fly    14 GSGMCKAGFAG--DDAPRAVFPSIVGR------PRHQGVMVGMGQKDSYVGDEAQSKRGILTLKY 70

Human    97 HVRR------EDLDKLHRAAWWG--KVPRKDLIVMLRDTDMN-KRDKQKRTALHLASANGNSEVV 152
            .:..      :|::|:....::.  :|..::..|:|.:..:| |.:::|.|.:...:.|.
  Fly    71 PIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNS----- 130

Human   153 QLLLDRRCQLNVLDNKKRTALIKAVQCQEDECVLMLLEHGADGNIQDEYGNTALHYAIYNEDKLM 217
                              .|:..|:|     .||.|...|....|..:.|:...|.....|...:
  Fly   131 ------------------PAMYVAIQ-----AVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYAL 172

Human   218 AKALL---LYGADIESKNKCGLTPLLLGVHEQK---------QEVVKFLIKKKANLNALD 265
            ..|:|   |.|.|        ||..|:.:..::         :|:|:. ||:|....|||
  Fly   173 PHAILRLDLAGRD--------LTDYLMKILTERGYSFTTTAEREIVRD-IKEKLCYVALD 223

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
POTEB	NP_001264233.1	ANK	130..255	CDD:238125	26/137 (19%)
		ANK 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00023	135..167		3/31 (10%)
		ANK repeat	137..166	CDD:293786	2/28 (7%)
		ANK 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00023	168..200		8/31 (26%)
		ANK repeat	168..199	CDD:293786	8/30 (27%)
		ANK	196..320	CDD:238125	20/82 (24%)
		ANK 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00023	201..233		8/34 (24%)
		ANK repeat	201..232	CDD:293786	8/33 (24%)
		ANK 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00023	234..266		11/41 (27%)
		ANK repeat	234..265	CDD:293786	9/39 (23%)
		ANK 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00023	267..299
		ANK repeat	267..298	CDD:293786
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	332..457
		SMC_N	<412..>542	CDD:330553
		CCDC144C	489..>542	CDD:317340
Act57B	NP_523800.1	PTZ00281	1..376	CDD:173506	53/255 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5277
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100127
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.710