DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CDH11 and CadN2

DIOPT Version :10

Sequence 1:NP_001788.2 Gene:CDH11 / 1009 HGNCID:1750 Length:796 Species:Homo sapiens
Sequence 2:NP_609855.3 Gene:CadN2 / 35071 FlyBaseID:FBgn0262018 Length:1799 Species:Drosophila melanogaster


Alignment Length:817 Identity:213/817 - (26%)
Similarity:328/817 - (40%) Gaps:223/817 - (27%)


- Green bases have known domain annotations that are detailed below.


Human    81 IDSGDG------NIKYILSGEG------AGTIFVIDDKSGNIHATKTLDREE---RAQYTLMAQA 130
            :.:.||      ||.|.|:|:|      |.:.|.|:..:|:|...|.|||::   |.|:.....|
  Fly   160 VTATDGDVDRPINIVYFLTGQGIDPDNPANSKFDINRTTGDIFVLKPLDRDQPNGRPQWRFTVFA 224

Human   131 VDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQVTASDADDPTYGNSA 195
            .| :....|...::..|.::|||||.|:|....|..||.|....|:||:.::|.|.|||....:|
  Fly   225 QD-EGGEGLVGYADIQVNLKDINDNAPQFPQGIYFGNVTENGTAGSSVMTMSAVDYDDPNESTNA 288

Human   196 KLVYSILE-------GQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKDMGGHMGGLSGTTK 253
            ||:|||.:       |.|.|.:|.:||:|:||:..:|||...:|.:.:.|.|    .|||.||..
  Fly   289 KLIYSIEKNVIEEETGAPIFEIEPETGLIKTAVCCLDRERTPDYSIQVVAMD----GGGLKGTGT 349

Human   254 VTITLTDVNDNPPKFPQSVYQMSVSE---AAVPGEEVGRVKAKDPDIGENGLVTYNIV--DGDGM 313
            .:|.:.|:||.||:|.:..:...|.|   ..:|...:..|..:|.|  |.....|.:|  .|.|.
  Fly   350 ASIRVKDLNDMPPQFTKDEWVTEVDETNGTYIPETPILTVTVQDED--ETNTFQYKVVPNSGFGA 412

Human   314 ESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFISNGPFKDTVT--------- 369
            :.|.:..:.: ..|.:|:.:|:|:|                ||...|...|:..|.         
  Fly   413 DKFAMVRNGD-GTGSLKIIQPLDYE----------------DPLQSSGFRFRIQVNDKGDDGPGG 460

Human   370 ----------VKISVEDA-DEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPD-AANSPIRYSID 422
                      |.:.:.|. |..|.|........:.|:...||::.:..|.|.| ..:|.:.|.|.
  Fly   461 SDKYHVAYSWVVVKLRDINDNVPKFDREHIEVSIYEDTKVGTILEQFKATDADQGGHSKVAYKIV 525

Human   423 RHTDLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQEAKVPVAIRVLDVNDNAPK 487
            |.|:..|.|.|: :.|.:...:|||||.....:|.:.|.:..:..:.|...:.:.|.|||||||.
  Fly   526 RSTNRKRQFAIS-DRGAVSIQRPLDRETQDRHHIQILAIDDGSPARTATATLTVIVKDVNDNAPT 589

Human   488 FAAPYEGFICESDQTKPLSNQPIVTISADDKDD--TANGPRFIFSLPP----EIIHNPNFTV--- 543
            ||..|:..:.|:     :|.:.|:.::|.|.||  ..||..|.|.|.|    ||  ...|.|   
  Fly   590 FAQDYKPTLPEN-----VSGKKILEVAAKDPDDRLRGNGGPFTFRLDPLASDEI--KAGFKVEYD 647

Human   544 -RDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPMSSTNTLTIKVCGCDVNGALLSCNAE 607
             |.:.:|...:.:....|.|:.|..|.:||.|.|.|.|.|:.|:|||:.:  .|||.        
  Fly   648 RRGDNENGVAIISSLRPFDREAQKSYAIPIEIKDNGAPAMTGTSTLTVTI--GDVND-------- 702

Human   608 AYILNAGLSTGALIAILACIVILLVIVVLFVTLRRQKKEPLIVFEEEDVRENIITYDDEGGGEED 672
                                               .|.:|        ..::::.|:.: |..:|
  Fly   703 -----------------------------------NKMQP--------GSKSVLVYNYQ-GQSQD 723

Human   673 TEAFDIATLQNPDGINGFIPRKDIKPEYQ-------------YMPRPGLR--------------- 709
            |....: .:.:||..:  :|.|....|.|             ...|.|.|               
  Fly   724 TPIGRV-YVNDPDDWD--VPDKKYYWEVQEHQRFKLDTDTGILTMRAGTRRGRYQLRFKVYDREH 785

Human   710 -----PAPNSVDVDDFINTRIQEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESATTDSDLDY 769
                 ||..||.|.|.....:|:|                    ||:  .||.:        .|.
  Fly   786 GQEDIPANLSVTVRDITAEAVQQA--------------------GSM--RLSHI--------TDE 820

Human   770 DYLQNWGP-----------RFK-KLAD-LYGSKDTFD 793
            |:::.|.|           ||: |||: ||..:|..|
  Fly   821 DFVRTWNPVKNQVEPSKLERFRNKLAELLYTDRDNVD 857

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CDH11NP_001788.2 CA 79..157 CDD:214520 28/90 (31%)
Cadherin_repeat 163..264 CDD:206637 41/107 (38%)
Cadherin_repeat 272..379 CDD:206637 24/131 (18%)
Cadherin_repeat 387..484 CDD:206637 27/97 (28%)
CA 514..598 CDD:214520 32/93 (34%)
CADH_Y-type_LIR 728..787 CDD:460041 15/71 (21%)
CadN2NP_609855.3 Cadherin_repeat 41..132 CDD:206637
Cadherin_repeat 140..248 CDD:206637 26/88 (30%)
Cadherin_repeat 256..359 CDD:206637 40/106 (38%)
CA 388..483 CDD:214520 22/113 (19%)
Cadherin_repeat 489..586 CDD:206637 27/97 (28%)
Cadherin_repeat 594..703 CDD:206637 38/160 (24%)
EGF_CA 977..1010 CDD:238011
LamG 1013..1198 CDD:238058
EGF_2 1233..1259 CDD:400365
LamG 1265..1426 CDD:238058
EGF_CA 1497..1535 CDD:238011
CADH_Y-type_LIR 1662..1719 CDD:460041
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.