DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FSBP and RDH54

DIOPT Version :9

Sequence 1:	NP_001243070.1	Gene:	FSBP / 100861412	HGNCID:	43653	Length:	299	Species:	Homo sapiens
Sequence 2:	NP_009629.6	Gene:	RDH54 / 852365	SGDID:	S000000277	Length:	958	Species:	Saccharomyces cerevisiae

Alignment Length:	369	Identity:	65/369 - (17%)
Similarity:	124/369 - (33%)	Gaps:	114/369 - (30%)

- Green bases have known domain annotations that are detailed below.

Human     2 VGKARSSNFTLSEKLDLLKLVKPYVKILEEHTNKHSVIVEKNRCWDIIAVNYNAIGVDRPPRTAQ 66
            |.|..:.:.|...|.......|.|..:.:.:...:.:::.||...::..:....:|....|...:
Yeast   238 VTKQTNEHMTTVPKTSQNSKAKKYYPVFDVNKIDNPIVMNKNAAAEVDVIVDPLLGKFLRPHQRE 302

Human    67 GLRTLYKRLKEYAK------------QELLQQKET----------------------------QS 91
            |::.:|..|...|:            :.|:.:.::                            |:
Yeast   303 GVKFMYDCLMGLARPTIENPDIDCTTKSLVLENDSDISGCLLADDMGLGKTLMSITLIWTLIRQT 367

Human    92 DFKSNIS---------EPTKKVMEMIP------------------QISSFCLVRDRNHIQSANLD 129
            .|.|.:|         ...||::.:.|                  :|....| ..||   |.::|
Yeast   368 PFASKVSCSQSGIPLTGLCKKILVVCPVTLIGNWKREFGKWLNLSRIGVLTL-SSRN---SPDMD 428

Human   130 EEAQAG----TSSLQVMLDHHPVAITVEVKQEEDIKPPPPLVLNSQQSDTLEQREEHELVHVMER 190
            :.|...    ..:.||::..:...::|..:.|:          |....|.|...|.|.|.:...:
Yeast   429 KMAVRNFLKVQRTYQVLIIGYEKLLSVSEELEK----------NKHLIDMLVCDEGHRLKNGASK 483

Human   191 SLSPSLSSVDMR----MTSSPSSIPRRDDFFRHESGEHFRSLLGYDPQILQMLKEEHQIILENQK 251
            .|: :|.|:|:|    :|.:|         .:::..|.|..:...:|.||..       ....::
Yeast   484 ILN-TLKSLDIRRKLLLTGTP---------IQNDLNEFFTIIDFINPGILGS-------FASFKR 531

Human   252 NFGLYVQEKRDGLKRRQQLEEELL-----RAKIEVEKLKAIRLR 290
            .|.:.:...||...|   ..||||     |:|..:|..|...||
Yeast   532 RFIIPITRARDTANR---YNEELLEKGEERSKEMIEITKRFILR 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FSBP	NP_001243070.1	Myb_DNA-bind_5	6..85	CDD:404714	13/90 (14%)
RDH54	NP_009629.6	DUF2439	108..>158	CDD:402138
		DEXHc_RAD54	296..573	CDD:350762	56/311 (18%)
		SF2_C_SNF	663..789	CDD:350180
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001533
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_105504
Panther	1	1.100	-	-	LDO	PTHR45629
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.910