DRSC/TRiP Functional Genomics Resources

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Protein Alignment PQBP1 and pqbp-1.1

DIOPT Version :10

Sequence 1:NP_005701.1 Gene:PQBP1 / 10084 HGNCID:9330 Length:265 Species:Homo sapiens
Sequence 2:NP_499890.2 Gene:pqbp-1.1 / 176847 WormBaseID:WBGene00020647 Length:280 Species:Caenorhabditis elegans


Alignment Length:319 Identity:100/319 - (31%)
Similarity:139/319 - (43%) Gaps:98/319 - (30%)


- Green bases have known domain annotations that are detailed below.


Human     1 MPLPVALQTRLAKRGILKHLEPEPEEEIIAEDYDDDPVDYEATRLE------------------- 46
            ||||.||..||.||||:|.     |||:|||:|:.:|   |....|                   
 Worm     1 MPLPPALLARLQKRGIVKQ-----EEEVIAENYEKEP---EKKSFEENSAGAPGCPNKWNQYHVC 57

Human    47 --------------------------------GLPPSWYKVFDPSCGLPYYWNADTDLVSWLSPH 79
                                            .||.:|.:|:|......|:||..||.|.|.||.
 Worm    58 LEFCYDHWGDGTPEYRLPERYVQNKNRMLAKFPLPENWVEVYDEGLAKYYFWNKTTDEVCWYSPR 122

Human    80 DPNSVVTKSAKKLRSSNADAEEKLDRSH-DKSDRGHDKSDRSHEKLDRG--HDKSDRGHDKSDRD 141
            .|.::::..|.::...:|..  ....|| .:.|....:.:..::|..||  .||..||::...|.
 Worm   123 HPRAIISDPAPRIAREHATV--LFGDSHASEEDNAARRRNFHNKKTSRGGNDDKQSRGNNAEKRK 185

Human   142 RERGYDKVDRERERDRERDRDRGYDKADREEGKERRHHRREELAPYPKSKKAVSRKDEELDPMDP 206
            |              |:....:|.| :|.:|        .:|:....:.|:|   |.:.:|||||
 Worm   186 R--------------RDPMTSQGPD-SDEDE--------LQEMTNKDRLKRA---KRKGIDPMDP 224

Human   207 SSYSDAPRGTWSTGLPKRNEAKTGADTTAAGPLFQQRPYPSPGAVLRANAEASRTKQQD 265
            ::|.|||.|.||.||  |.:..||||.||.||||||||||:|||:||      :.|.||
 Worm   225 AAYGDAPVGKWSDGL--RVDQVTGADVTAGGPLFQQRPYPAPGAILR------KQKPQD 275

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PQBP1NP_005701.1 WW 47..78 CDD:197736 12/30 (40%)
Disordered. /evidence=ECO:0000269|PubMed:19303059 94..265 59/173 (34%)
5 X 7 AA approximate tandem repeats of D-R-[SG]-H-D-K-S 104..138 10/36 (28%)
3 X 2 AA tandem repeats of [DE]-R 139..144 2/4 (50%)
7 X 2 AA tandem repeats of [DE]-R 150..163 1/12 (8%)
Important for interaction with TXNL4A 245..255 7/9 (78%)
pqbp-1.1NP_499890.2 WW 90..122 CDD:197736 13/31 (42%)

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