DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment USH1C and CG5921

DIOPT Version :9

Sequence 1:	XP_016872564.1	Gene:	USH1C / 10083	HGNCID:	12597	Length:	956	Species:	Homo sapiens
Sequence 2:	NP_727061.2	Gene:	CG5921 / 31538	FlyBaseID:	FBgn0029835	Length:	886	Species:	Drosophila melanogaster

Alignment Length:	229	Identity:	89/229 - (38%)
Similarity:	128/229 - (55%)	Gaps:	15/229 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    82 SRKLKEVRLDRLHPEGL-----------GLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIV 135
            |.:|:.:||.|.|...|           |.:||||.|.|.|.|:||:..||:|...||::||:|:
  Fly    58 SSRLRVLRLVRPHQRRLLVGGPERGSTYGFTVRGGREHGTGFFVSHVEHGGEAHLKGLRIGDQIL 122

Human   136 RINGYSISSCTHEEVINLIRTKKTVSIKVRHIGLIPVKSSPDEPLTWQYVDQFVSESGGVRGSLG 200
            ||||:.:....|:|.|.|:..:..|::|||.:|::||:..|:|.|:|..|.  :....|......
  Fly   123 RINGFRLDDAVHKEFIQLVAGQDRVTLKVRGVGMLPVRDLPEERLSWSVVK--LPSVSGTPSESS 185

Human   201 SPGNRENKEKKVFISL-VGSR-GLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNG 263
            ..|.|....:.:.:.| |..| .||..|..||..|||||:...|..|::.|.||..||||:.||.
  Fly   186 FKGERRGASRDISVVLHVAPRTKLGLGICKGPEWKPGIFVQFTKDRSVAREAGLRPGDQILSVNS 250

Human   264 VDFSNLDHKEAVNVLKSSRSLTISIVAAAGRELF 297
            :|||::...|||.|:|||..|.:.:..|||.:||
  Fly   251 IDFSDVLFSEAVAVMKSSSKLDMVVRTAAGCDLF 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
USH1C	XP_016872564.1	None
CG5921	NP_727061.2	PDZ_signaling	82..152	CDD:238492	29/69 (42%)
CG5921	NP_727061.2	PDZ_signaling	197..276	CDD:238492	35/78 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10387
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007864
OrthoInspector	1	1.000	-	-		oto91339
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23116
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11064
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.900